Summary
Autologous tubular tissues as small caliber vascular prostheses were created in vivo using tissue engineering. We named them “Biotubes”. The six kinds of polymeric rods made of polyethylene (PE), poly-fluoroacetate (PFA), poly-methyl methacrylate (PMMA), segmented poly-urethane (PU), polyvinyl chloride (PVC) and silicone (Si) as a mold were embedded in the dorsal skin of six of New Zealand White rabbits. Biotubes were formed after 1 month by fibrous tissue encapsulation around the polymeric implant except PFA. None of the Biotubes were ruptured when a hydrostatic pressure was applied up to 200 mmHg. The wall thickness of the Biotubes ranged from 50 to 200 µm depending on the implant materials in the order PFA<PVC<PMMA <PU<PE. The tissue mostly consisted of fibroblasts and collagen-rich extracellular matrices. The tissue created by Si rod was relatively firm and inelastic and the one created by PMMA was relatively soft. For PMMA, PE and PVC the stiffness parameter (β value; one of the indexes for compliance) of the Biotubes was similar to those of the human coronary, femoral and carotid arteries, respectively. Biotubes, autologous tubular tissues, can be applied for use as small caliber vessels and are ideal prostheses because of avoidance of immunological rejection.
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Ishibashi-Ueda, H., Nakayama, Y. (2005). Biotube Technology for a Novel Tissue-Engineered Blood Vessels. In: Mori, H., Matsuda, H. (eds) Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches. Springer, Tokyo. https://doi.org/10.1007/4-431-27378-6_8
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DOI: https://doi.org/10.1007/4-431-27378-6_8
Publisher Name: Springer, Tokyo
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