Summary
The blood- brain barrier (BBB) has emerged as a regulatory interface that controls the exchange of informational molecules between the blood and the central nervous system (CNS) fluids (the brain interstitial and the cerebrospinal fluid). As such, it is a pivotal point in a humoral-based, endocrine-like communication between the CNS and peripheral tissues. For example, the BBB controls the entry of major feeding hormones into the CNS from the blood, including leptin. Impaired transport of leptin across the BBB is an early cause of leptin resistance. Leptin transport is regulated by alpha1-adrenergics, which simulate transport, and triglycerides, which inhibit it. The ability of triglycerides to inhibit leptin transport may have evolved as a response to the hypertriglyceridemia of starvation. If so, their ability to inhibit leptin transport in obesity may be a metabolic case of mistaken identity.
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Banks, W.A., Farr, S.A., Morley, J.E. (2006). The Role of the Blood-Brain Barrier in Feeding: Leptin. In: Homma, I., Shioda, S. (eds) Breathing, Feeding, and Neuroprotection. Springer, Tokyo. https://doi.org/10.1007/4-431-28775-2_4
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DOI: https://doi.org/10.1007/4-431-28775-2_4
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