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Induced Pluripotent Stem Cells in Disease Modelling and Regeneration

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Cell Biology and Translational Medicine, Volume 5

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1144))

Abstract

The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has raised extreme hope among both scientists and society by means of development of personalized and regenerative medicine. The field of stem cell research has been accelerating with a drastic speed afterwards and many iPSC lines has been produced for understanding the mechanisms of many debilitating diseases which arise in a variety of organ systems. In this review article we try to focus on the current research regarding the use of iPSCs in both disease modeling and regeneration.

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Abbreviations

CF:

Cystic Fibrosis

CM:

Cardiomyocyte

CRISPR/Cas9:

Clustered Regularly Interspaced Palindromic Repeats/Cas9

FH:

Familial Hypercholesterolemia

hiPSC:

Human Induced Pluripotent Stem Cells

iPSCs:

Induced Pluripotent Stem Cells

LQTS:

Long QT Syndrome

MHC:

Major Histocompatibility Complex

MI:

Myocardial Infarction

WHO:

World Health Organization

ZFN:

Zinc Finger Nuclease

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Acknowledgement

Zeynep Tokcaer-Keskin was supported by TUBITAK 114C043, ABAPKO project no 2017/01/12.

Many thanks to Dr. Emre Deniz and Kevser Tokcaer for critical reading. The authors apologize in advance for not including all relevant citations on the subject matter.

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  1. Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey

    Burcu Talug & Zeynep Tokcaer-Keskin

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Correspondence to Zeynep Tokcaer-Keskin .

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  1. (Retired), Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Talug, B., Tokcaer-Keskin, Z. (2018). Induced Pluripotent Stem Cells in Disease Modelling and Regeneration. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 5. Advances in Experimental Medicine and Biology(), vol 1144. Springer, Cham. https://doi.org/10.1007/5584_2018_290

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