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Quinoxaline 1,4-Dioxide and Phenazine 5,10-Dioxide. Chemistry and Biology

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Bioactive Heterocycles V

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 11))

Abstract

Since the beginning of the past century, quinoxaline 1,4-dioxide and phenazine 5,10-dioxide derivatives have been known to be potent bioactive compounds. Maybe the most relevant reported biological property has been their ability to act as bioreductive agents, selective cytotoxins against hypoxic cells; moreover, other significant activities have been identified, such as promotion-growth ability, antibacterial, antifungal, antiparasite, cytotoxic, as well as herbicide properties. Structure-activity relationship studies have been performed and important findings have been described. On the other hand, specific side effects for these compounds have been studied and identified being the most relevant mutagenic and clastogenic properties. These kinds of compounds have been also reported as components in the material sciences. This chapter includes old and more recent methods of synthesis of quinoxaline 1,4-dioxide and phenazine 5,10-dioxide derivatives, chemical and biological reactivity, biological properties and mode of action, structure-activity studies and other relevant chemical and biological properties.

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Authors and Affiliations

  1. Laboratorio de Química Orgánica, Facultad de Ciencias/Facultad de Química, Universidad de la República, Iguá 4225, 11400, Montevideo, Uruguay

    Mercedes González & Hugo Cerecetto

  2. Centro de Investigaciones en Farmacobiología Aplicada (CIFA), Universidad de Navarra, Irunlarrea s/n, 31080, Pamplona, Spain

    Antonio Monge

Authors
  1. Mercedes González
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  2. Hugo Cerecetto
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  3. Antonio Monge
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Corresponding author

Correspondence to Mercedes González .

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Mahmud Tareq Hassan Khan

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© 2007 Springer-Verlag Berlin Heidelberg

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González, M., Cerecetto, H., Monge, A. (2007). Quinoxaline 1,4-Dioxide and Phenazine 5,10-Dioxide. Chemistry and Biology. In: Khan, M.T.H. (eds) Bioactive Heterocycles V. Topics in Heterocyclic Chemistry, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2007_066

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