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Transport of Proteases to the Vacuole: ER Export Bypassing Golgi?

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The Plant Endoplasmic Reticulum

Part of the book series: Plant Cell Monographs ((CELLMONO,volume 4))

Abstract

Most vacuolar proteases are transported from the endoplasmic reticulum (ER) to vacuoles via the Golgiapparatus. However, higher plants possess a unique papain-type protease, termed KDEL-tailed protease.This protease has a Lys − Asp − Glu − Leu (KDEL)sequence at its C-terminus, which is known as a retention signal of soluble proteins to the ER, althoughthe protease localizes and functions in vacuoles. Investigations on the intracellular trafficking pathwayof this unique enzyme have suggested that the protease is transported from the ER to vacuoles by bypassingthe Golgi apparatus. In this review, Golgi-dependent vacuolar trafficking of proteases is first explained,then the Golgi-independent vacuolar transport pathway of the KDEL-tailed protease is described.

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  1. Department of Biological Sciences, Tokyo Metropolitan University, Minami-osawa 1-1, Hachioji, 192-0397, Tokyo, Japan

    Takashi Okamoto

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  1. Takashi Okamoto
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Correspondence to Takashi Okamoto .

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David G. Robinson

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© 2006 Springer-Verlag Berlin Heidelberg

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Okamoto, T. (2006). Transport of Proteases to the Vacuole: ER Export Bypassing Golgi?. In: Robinson, D.G. (eds) The Plant Endoplasmic Reticulum. Plant Cell Monographs, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7089_055

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