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In Vivo Studies: Inhibiting Biofilm-Associated Bacterial Infections Using QSIs

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Control of Biofilm Infections by Signal Manipulation

Part of the book series: Springer Series on Biofilms ((BIOFILMS,volume 2))

Abstract

This chapter reviews animal studies carried out using quorum-sensing inhibitors of Gram-negative and Gram-positive bacterial biofilm infections. Animal studies include the use of biofilm inhibitors to suppress Pseudomonas aeruginosa lung infections in mice, and the use of biofilm inhibitors to suppress antibiotic-resistant staphylococcal infections like methicillin-resistant Staphylococcus aureus in rat graft and central venous catheter models and mouse cellulitis models. The advantages of using biofilm inhibitors over those of conventional antibiotics, and the choice of inhibitor to be used are discussed.

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Author information

Authors and Affiliations

  1. Cummings School of Veterinary Medicine, Department of Biomedical Sciences, Tufts University, 200 Westboro Rd, North Grafton, 01536, MA, USA

    Naomi Balaban

  2. BioCentrum-DTU, Technical University of Denmark, Bio Science and Technology Bldg 227, DK-2800, Kgs Lyngby, Denmark

    Michael Givskov

  3. Innovation, Cultures & Enzymes Division, Christian Hansen A/S, Bøge Allé 10-12, Hørsholm, DK-2970, Denmark

    Thomas Bovbjerg Rasmussen

Authors
  1. Naomi Balaban
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  2. Michael Givskov
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  3. Thomas Bovbjerg Rasmussen
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Correspondence to Naomi Balaban .

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Naomi Balaban

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© 2008 Springer-Verlag Berlin Heidelberg

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Balaban, N., Givskov, M., Rasmussen, T. (2008). In Vivo Studies: Inhibiting Biofilm-Associated Bacterial Infections Using QSIs. In: Balaban, N. (eds) Control of Biofilm Infections by Signal Manipulation. Springer Series on Biofilms, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7142_2007_012

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