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The Hypocretin/Orexin Neuronal Networks in Zebrafish

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Behavioral Neuroscience of Orexin/Hypocretin

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 33))

Abstract

The hypothalamic Hypocretin/Orexin (Hcrt) neurons secrete two Hcrt neuropeptides. These neurons and peptides play a major role in the regulation of feeding, sleep wake cycle, reward-seeking, addiction, and stress. Loss of Hcrt neurons causes the sleep disorder narcolepsy. The zebrafish has become an attractive model to study the Hcrt neuronal network because it is a transparent vertebrate that enables simple genetic manipulation, imaging of the structure and function of neuronal circuits in live animals, and high-throughput monitoring of behavioral performance during both day and night. The zebrafish Hcrt network comprises ~16–60 neurons, which similar to mammals, are located in the hypothalamus and widely innervate the brain and spinal cord, and regulate various fundamental behaviors such as feeding, sleep, and wakefulness. Here we review how the zebrafish contributes to the study of the Hcrt neuronal system molecularly, anatomically, physiologically, and pathologically.

The authors “Idan Elbaz” and “Talia Levitas-Djerbi” contributed equally to this work.

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Acknowledgments

This work was supported by the Israel Science Foundation (grant no. 690/15), the Legacy Heritage Biomedical Program of the Israel Science Foundation (grant no. 992/14), and by the US-Israel Binational Science Foundation (BSF, grant no. 2011335). IE is supported by the Nehemia Levtzion scholarship from the Council for Higher Education, Israel.

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    Authors and Affiliations

    1. The Mina & Everard Goodman Faculty of Life Sciences and The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, 5290002, Israel

      Idan Elbaz, Talia Levitas-Djerbi & Lior Appelbaum

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    1. Idan Elbaz
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    2. Talia Levitas-Djerbi
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    3. Lior Appelbaum
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    Correspondence to Lior Appelbaum .

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    1. Florey Institute of Neuroscience & Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, VIC, Australia

      Andrew J Lawrence

    2. Dep Psychiatry & Behav Sciences, Stanford University, Stanford, CA, USA

      Luis de Lecea

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    Elbaz, I., Levitas-Djerbi, T., Appelbaum, L. (2016). The Hypocretin/Orexin Neuronal Networks in Zebrafish. In: Lawrence, A.J., de Lecea, L. (eds) Behavioral Neuroscience of Orexin/Hypocretin. Current Topics in Behavioral Neurosciences, vol 33. Springer, Cham. https://doi.org/10.1007/7854_2016_59

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