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Photorhabdus luminescens Toxins TccC3 and TccC5: Insecticidal ADP-Ribosyltransferases that Modify Threonine and Glutamine

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Endogenous ADP-Ribosylation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 384))

Abstract

The ADP-ribosyltransferases TccC3 and TccC5 are the biologically active TcC components of the tripartite Photorhabdus luminescens Tc toxin, which consist of TcA, TcB, and TcC components. TcA is the binding and membrane translocation component. TcB is a functional linker between TcC and TcA and also involved in the translocation of the toxin. While TccC3 ADP-ribosylates actin at threonine 148, TccC5 modifies Rho proteins at glutamine 61/63. Both modifications result in major alteration of the actin cytoskeleton. Here we discuss structure and function of the Tc toxin and compare its ADP-ribosyltransferase activities with other types of actin and Rho modifying toxins.

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Acknowledgments

This work was supported by the German Research Foundation (DFG) and the Center for Biological Signaling Studies (BIOSS) in Freiburg (Germany).

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  1. Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104, Freiburg, Germany

    Klaus Aktories, Gudula Schmidt & Alexander E. Lang

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  1. Klaus Aktories
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  2. Gudula Schmidt
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  3. Alexander E. Lang
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Correspondence to Klaus Aktories .

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  1. Institute of Immunology, University Medical Center, Hamburg, Germany

    Friedrich Koch-Nolte

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Aktories, K., Schmidt, G., Lang, A.E. (2014). Photorhabdus luminescens Toxins TccC3 and TccC5: Insecticidal ADP-Ribosyltransferases that Modify Threonine and Glutamine. In: Koch-Nolte, F. (eds) Endogenous ADP-Ribosylation. Current Topics in Microbiology and Immunology, vol 384. Springer, Cham. https://doi.org/10.1007/82_2014_382

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