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Computational Modeling of Electromagnetic and Thermal Effects for a Dual-Unit Retinal Prosthesis: Inductive Telemetry, Temperature Increase, and Current Densities in the Retina

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Artificial Sight

Abstract

Recent advances in electromagnetic and thermal modeling of a dual-unit retinal prosthesis are presented. The focus is on the latest computational methods to quantify electrical and thermal deposition in the human tissue with the ultimate goal of addressing safety concerns and optimizing the overall performance of the system. A Partial Inductance Method (PIM) is used for the computation of the electrical coupling parameters of the radiating and receiving telemetry coils. Results for the inductive coil coupling are presented and different coil geometries are compared. Further, a finite difference method for the solution of a bio-heat equation is used to compute the temperature increase caused by the implanted electronics and the electromagnetic absorption due to the external power and data telemetry link. Temperature increases due to the implanted microchip, coils, and stimulating electrode array are shown. Finally, our computational approach based on a multi-resolution impedance method is used for the computation current spread in the human tissue. Results are presented showing variations of current spread in the retina and eye due to different electrode array geometries and placement configurations.

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References

  1. J. Wyatt and J. Rizzo, “Ocular implants for the blind,” IEEE Spectrum, vol. 33, no. 5, pp. 47–53, 1996.

    Article  Google Scholar 

  2. A. Y. Chow, M. T. Pardue, G. A. Peyman, and N. S. Peachey, “Development and application of subretinal semiconductor microphotodiode array,” in Vitreoretinal Surgical Techniques, F. A. Peyman, S. A. Meffert, M. D. Conway, and F. Chou, Eds. London, UK: Martin Dunitz, 2001, pp. 575–578.

    Google Scholar 

  3. E. Zrenner, “Will retinal implants restore vision?,” Science, vol. 295, no. 5557, pp. 1022–1025, February 8, 2002.

    Article  ADS  Google Scholar 

  4. M. S. Humayun, J. D. Weiland, B. Justus, C. Merrit, J. Whalen, D. Piyathaisere, S. J. Chen, E. Margalit, G. Fujii, R. J. Greenberg, E. J. de Juan, D. Scribner, and W. Liu, “Towards a completely implantable, light-sensitive intraocular retinal prosthesis,” presented at Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2001.

    Google Scholar 

  5. M. S. Humayun, E. de Juan Jr., J. D. Weiland, G. Dagnelie, S. Katona, R. Greenberg, and S. Suzuki, “Pattern electrical stimulation of the human retina,” Vision Research, vol. 39, no. 15, pp. 2569–2576, 1999/7 1999.

    Article  Google Scholar 

  6. N. d.-N. Donaldson and T. A. Perkins, “Analysis of resonant coupled coils in the design of radio frequency transcutaneous links,” Medical & Biological Engineering & Computing, vol. 21, no. 5, pp. 612–627, Sept. 1983.

    Article  Google Scholar 

  7. F. C. Flack, E. D. James, and D. M. Schlapp, “Mutual inductance of air-cored coils: Effect on design of radio-frequency coupled implants,” Medical & Biological Engineering, vol. 9, no. 2, pp. 79–85, March 1971.

    Article  Google Scholar 

  8. D. C. Galbraith, M. Soma, and R. L. White, “A wide-band efficient inductive transdermal power and data link with coupling insensitive gain,” IEEE Transactions on Biomedical Engineering, vol. 34, no. 4, pp. 265–275, April 1987.

    Article  Google Scholar 

  9. C. R. Neagu, H. V. Jansen, A. Smith, J. G. E. Gardeniers, and M. C. Elwenspoek, “Characterization of a planar microcoil for implantable microsystems,” Sensors and Actuators A: Physical, vol. 62, no. 1–3, pp. 599–611, July 1997.

    Article  Google Scholar 

  10. M. Soma, D. C. Galbraith, and R. L. White, “Radio-frequency coils in implantable devices: Misalignment analysis and design procedure,” IEEE Transactions on Biomedical Engineering, vol. 34, no. 4, pp. 276–282, April 1987.

    Article  Google Scholar 

  11. A. E. Ruehli, “Inductance calculations in a complex integrated-circuit environment,” IBM Journal of Research and Development, vol. 16, no. 5, pp. 470–481, Sept. 1972.

    Article  Google Scholar 

  12. E. B. Rosa, “The self and mutual inductances of linear conductors,” Bulletin of the Bureau of Standards, vol. 4, no. 2, pp. 301–344, 1908.

    MathSciNet  Google Scholar 

  13. F. W. Grover, Inductance Calculations: Working Formulas and Tables. New York: D. Van Nostrand, 1946.

    Google Scholar 

  14. E. B. Rosa and F. W. Grover, “Formulas and tables for the calculation of mutual and self-inductance [revised],” Bulletin of the Bureau of Standards, vol. 8, no. 1, pp. 1–237, 1 January 1912.

    Google Scholar 

  15. H. H. Pennes, “Analysis of tissue and arterial blood temperatures in the resting human forearm,” Journal of Applied Physiology, vol. 1, no. 2, pp. 93–122, 1 August 1948.

    Google Scholar 

  16. G. Lazzi, S. C. DeMarco, W. Liu, J. D. Weiland, and M. S. Humayun, “Computed SAR and thermal elevation in a 0.25-mm 2D model of the human eye and head in response to an implanted retinal stimulator – part II: results,” IEEE Transactions on Antennas and Propagation, vol. 51, no. 9, pp. 2286–2295, 2003.

    Article  ADS  Google Scholar 

  17. P. Bernardi, M. Cavagnaro, S. Pisa, and E. Piuzzi, “Specific absorption rate and temperature elevation in a subject exposed in the far-field of radio-frequency sources operating in the 10–900-MHz range,” Biomedical Engineering, IEEE Transactions on, vol. 50, no. 3, pp. 295–304, 2003.

    Article  Google Scholar 

  18. D. Poulikakos, Conduction Heat Transfer. Englewood Cliffs, N.J.: Prentice-Hall, 1994.

    Google Scholar 

  19. K. Gosalia, J. Weiland, M. Humayun, and G. Lazzi, “Thermal elevation in the human eye and head due to the operation of a retinal prosthesis,” Biomedical Engineering, IEEE Transactions On, vol. 51, no. 8, pp. 1469–1477, 2004.

    Article  Google Scholar 

  20. M. J. Ackerman, “The Visible Human Project,” Proceedings of the IEEE, vol. 86, no. 3, pp. 504–511, 1998.

    Article  Google Scholar 

  21. “Dosimetry Models,” ftp://starview.brooks.af.mil/EMF/dosimetry_models/.

    Google Scholar 

  22. S. C. DeMarco, G. Lazzi, W. Liu, J. D. Weiland, and M. S. Humayun, “Computed SAR and thermal elevation in a 0.25-mm 2D model of the human eye and head in response to an implanted retinal stimulator – part I: models and methods,” Antennas and Propagation, IEEE Transactions On, vol. 51, no. 9, pp. 2274–2285, 2003.

    Article  ADS  Google Scholar 

  23. C. Gabriel, R. J. Sheppard, and E. H. Grant, “Dielectric properties of ocular tissues at 37 degrees C,” Physics in Medicine and Biology, vol. 28, no. 1, pp. 43–49, January 1983.

    Article  ADS  Google Scholar 

  24. C. Gabriel, S. Gabriel, and E. Corthout, “The dielectric properties of biological tissues: I. Literature survey,” Physics in Medicine and Biology, no. 11, pp. 2231–2249, 1996.

    Article  ADS  Google Scholar 

  25. S. Gabriel, R. W. Lau, and C. Gabriel, “The dielectric properties of biological tissues: II. Measurements in the frequency range 10Hz to 20GHz,” Physics in Medicine and Biology, no. 11, pp. 2251–2269, 1996.

    Article  ADS  Google Scholar 

  26. S. Gabriel, R. W. Lau, and C. Gabriel, “The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues,” Physics in Medicine and Biology, no. 11, pp. 2271–2293, 1996.

    Article  ADS  Google Scholar 

  27. J. T. Ernest, “Choroidal Circulation,” in Retina, S. J. Ryan, Ed., 2nd ed. St. Louis: Mosby, 1994, pp. 76–80.

    Google Scholar 

  28. P. W. V. Gurney, ‘Is Our “Inverted” Retina Really “Bad Design”?,’ in Creation Ex Nihilo, vol. 13, 1999, pp. 37–44.

    Google Scholar 

  29. L. M. Parver, C. Auker, and D. O. Carpenter, “Choroidal Blood-Flow as a Heat Dissipating Mechanism in the Macula,” American Journal of Ophthalmology, vol. 89, no. 5, pp. 641–646, 1980.

    Google Scholar 

  30. G. Lazzi, “Thermal Effects of Bioimplants,” to appear in Engineering in Medicine and Biology Magazine, 2005.

    Google Scholar 

  31. T. I. C. o. N.-I. R. P. (ICNIRP), “Guidelines for Limiting Exposure to Time-Varying Electric, Magnetic, and Electromagnetic Fields (up to 300GHz),” Health Physics, vol. 74, no. 4, pp. 494–522, April 1998.

    Google Scholar 

  32. O. P. Gandhi, J. F. DeFord, and H. Kanai, “Impedance Method for Calculation of Power Deposition Patterns in Magnetically Induced Hyperthermia,” IEEE Transactions on Biomedical Engineering, vol. BME-31, no. 10, pp. 644–651, October 1984.

    Article  Google Scholar 

  33. M. Eberdt, “A multi-resolution meshing scheme for the impedance method,” North Carolina State University. 2001, pp. viii, 73 leaves.

    Google Scholar 

  34. M. Eberdt, P. K. Brown, and G. Lazzi, “Two-dimensional SPICE-linked multi-resolution impedance method for low-frequency electromagnetic interactions,” IEEE Transactions on Biomedical Engineering, vol. 50, no. 7, pp. 881–889, July 2003.

    Article  Google Scholar 

  35. D. W. Armitage, H. H. LeVeen, and R. Pethig, “Radiofrequency-induced hyperthermia: computer simulation of specific absorption rate distributions using realistic anatomical models,” Physics in Medicine and Biology, vol. 28, no. 1, pp. 31–42, January 1983.

    Article  ADS  Google Scholar 

  36. P. K. Brown, “A three-dimensional multi-resolution admittance method for low-frequency bioelectromagnetic interaction,” in Electrical and Computer Engineering Thesis. Raleigh: North Carolina State University 2005.

    Google Scholar 

  37. C. J. Karwoski, D. A. Frambach, and L. M. Proenza, “Laminar profile of resistivity in frog retina,” Journal of Neurophysiology, vol. 54, no. 6, pp. 1607–1619, December 1985.

    Google Scholar 

  38. R. W. Rodieck, “The Primate Retina,” in Comparative Primate Biology, vol. 4, G. Mitchell and J. Erwin, Eds. New York: A. R. Liss, 1986, pp. 203–274.

    Google Scholar 

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Schmidt, S., Cela, C.J., Singh, V., Weiland, J., Humayun, M.S., Lazzi, G. (2007). Computational Modeling of Electromagnetic and Thermal Effects for a Dual-Unit Retinal Prosthesis: Inductive Telemetry, Temperature Increase, and Current Densities in the Retina. In: Humayun, M.S., Weiland, J.D., Chader, G., Greenbaum, E. (eds) Artificial Sight. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49331-2_15

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