Adult Laryngopharyngeal Reflux

Abstract

A computerized PubMed search of MEDLINE 1966-January 2006 was performed using the terms “laryngopharyngeal reflux” (LPR) and “supraesophageal reflux disease.” The resulting articles were combined into a first group and cross-referenced with a second group of articles using the keywords “treatment of reflux.” This process yielded 91 articles which were reviewed. Their references were manually cross-checked for any further relevant articles which yielded three additional pertinent studes. This search was reverified by cross-referencing studies that mapped to both the medical subject heading “gastroesophageal reflux” and “laryngeal disease.” All of these articles were reviewed to determine which met the following inclusion criteria: 1) distinct patient population of adults (>-18 years old) with symptoms and signs suggesting LPR, 2) intervention with a proton pump inhibitor (PPI) versus placebo, 3) outcome measured by patient questionnaire and video laryngoscopy.