Skip to main content
SpringerLink
Log in

Medical, Psychosocial, and Health-Related Quality of Life Issues in Breast Cancer Survivors

  • Chapter
Cancer Survivorship

Abstract

Women with breast cancer account for the largest group of female cancer survivors. It is estimated that there are currently 10.5 million cancer survivors in the United States; 40% of the female survivors are breast cancer survivors.1 The growing number of breast cancer survivors reflects increasing incidence of the disease, diagnosis at earlier stages when outcome is better, and widespread adoption of effective adjuvant treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. http://dccps.nci.gov/ocs/prevalence/prevalence.html survivor, accessed October 1, 2006.

    Google Scholar 

  2. Gerber LH. A review of measures of lymphedema. Cancer (Phila) 1998;83:2803–2804.

    Article  PubMed  CAS  Google Scholar 

  3. Erickson VS, Pearson ML, Ganz PA, Adams J, Kahn KL. Arm edema in breast cancer patients. J Natl Cancer Inst 2001;93:96–111.

    Article  PubMed  CAS  Google Scholar 

  4. Schrenk P, Rieger R, Shamiyeh A, Wayand W. Morbidity following sentinel lymph node biopsy versus axillary lymph node dissection for patients with breast carcinoma. Cancer (Phila) 2000;88:608–614.

    Article  PubMed  CAS  Google Scholar 

  5. Gerber L, Lampert M, Wood C, et al. Comparison of pain, motion, and edema after modified radical mastectomy vs. local excision with axillary dissection and radiation. Breast Cancer Res Treat 1992;21:139–145.

    Article  PubMed  CAS  Google Scholar 

  6. Werner RS, McCormick B, Petrek J, et al. Arm edema in conservatively managed breast cancer: obesity is a major predictive factor. Radiology 1991;180:177–184.

    PubMed  CAS  Google Scholar 

  7. Tasmuth T, von Smitten K, Kalso E. Pain and other symptoms during the first year after radical and conservative surgery for breast cancer. Br J Cancer 1996;74:2024–2031.

    PubMed  CAS  Google Scholar 

  8. Paci E, Cariddi A, Barchielli A, et al. Long-term sequelae of breast cancer surgery. Tumori 1996;82:321–324.

    PubMed  CAS  Google Scholar 

  9. Yeoh EK, Denham JW, Davies SA, Spittle MF. Primary breast cancer. Complications of axillary management. Acta Radiol Oncol 1986;25:105–108.

    PubMed  CAS  Google Scholar 

  10. Kiel KD, Rademacker AW. Early-stage breast cancer: arm edema after wide excision and breast irradiation. Radiology 1996;198:279–283.

    PubMed  CAS  Google Scholar 

  11. Keramopoulos A, Tsionou C, Minaretzis D, Michalas S, Aravantinos D. Arm morbidity following treatment of breast cancer with total axillary dissection: a multivariated approach. Oncology 1993;50:445–449.

    Article  PubMed  CAS  Google Scholar 

  12. Liljegren G, Holmberg L. Arm morbidity after sector resection and axillary dissection with or without postoperative radiotherapy in breast cancer stage I. Results from a randomised trial. Uppsala-Orebro Breast Cancer Study Group. Eur J Cancer 1997;33:193–199.

    Article  PubMed  CAS  Google Scholar 

  13. Senofsky GM, Moffat FL Jr, Davis K, et al. Total axillary lymphadenectomy in the management of breast cancer. Arch Surg 1991;126:1336–1341; discussion 1341–1342.

    PubMed  CAS  Google Scholar 

  14. Kissin MW, Querci della Rovere G, Easton D, Westbury G. Risk of lymphoedema following the treatment of breast cancer. Br J Surg 1986;73:580–584.

    Article  PubMed  CAS  Google Scholar 

  15. Borup Christensen S, Lundgren E. Sequelae of axillary dissection vs. axillary sampling with or without irradiation for breast cancer. A randomized trial. Acta Chir Scand 1989;155:515–519.

    PubMed  CAS  Google Scholar 

  16. Lash TL, Silliman RA. Patient characteristics and treatments associated with a decline in upper-body function following breast cancer therapy. J Clin Epidemiol 2000;53:615–622.

    Article  PubMed  CAS  Google Scholar 

  17. Silliman RA, Prout MN, Field T, Kalish SC, Colton T. Risk factors for a decline in upper body function following treatment for early stage breast cancer. Breast Cancer Res Treat 1999;54:25–30.

    Article  PubMed  CAS  Google Scholar 

  18. Segerstrom K, Bjerle P, Nystrom A. Importance of time in assessing arm and hand function after treatment of breast cancer. Scand J Plast Reconstr Surg Hand Surg 1991;25:241–244.

    PubMed  CAS  Google Scholar 

  19. Lin PP, Allison DC, Wainstock J, et al. Impact of axillary lymph node dissection on the therapy of breast cancer patients. J Clin Oncol 1993;11:1536–1544.

    PubMed  CAS  Google Scholar 

  20. Passik SD, McDonald MV. Psychosocial aspects of upper extremity lymphedema in women treated for breast carcinoma. Cancer (Phila) 1998;83:2817–2820.

    Article  PubMed  CAS  Google Scholar 

  21. Woods M, Tobin M, Mortimer P. The psychosocial morbidity of breast cancer patients with lymphoedema. Cancer Nurs 1995;18:467–471.

    Article  PubMed  CAS  Google Scholar 

  22. Tobin MB, Lacey HJ, Meyer L, Mortimer PS. The psychological morbidity of breast cancer-related arm swelling. Psychological morbidity of lymphoedema. Cancer (Phila) 1993;72:3248–3252.

    Article  PubMed  CAS  Google Scholar 

  23. Maunsell E, Brisson J, Deschenes L. Arm problems and psychological distress after surgery for breast cancer. Can J Surg 1993;36:315–320.

    PubMed  CAS  Google Scholar 

  24. Harris PF, Remington PL, Trentham-Dietz A, Allen CI, Newcomb PA. Prevalence and treatment of menopausal symptoms among breast cancer survivors. J Pain Symptom Manag 2002;23:501–509.

    Article  Google Scholar 

  25. Ganz PA. Menopause and breast cancer: symptoms, late effects, and their management. Semin Oncol 2001;28:274–283.

    Article  PubMed  CAS  Google Scholar 

  26. Goodwin PJ, Ennis M, Pritchard KI, Trudeau M, Hood N. Risk of menopause during the first year after breast cancer diagnosis. J Clin Oncol 1999;17:2365–2370.

    PubMed  CAS  Google Scholar 

  27. Bines J, Oleske DM, Cobleigh MA. Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 1996;14:1718–1729.

    PubMed  CAS  Google Scholar 

  28. Bachmann GA. Vasomotor flushes in menopausal women. Am J Obstet Gynecol 1999;180:S312–S316.

    Article  PubMed  CAS  Google Scholar 

  29. Schwingl PJ, Hulka BS, Harlow SD. Risk factors for menopausal hot flashes. Obstet Gynecol 1994;84:29–34.

    PubMed  CAS  Google Scholar 

  30. Theriault RL, Sellin RV. Estrogen-replacement therapy in younger women with breast cancer. J Natl Cancer Inst Monogr 1994;16:149–152.

    PubMed  Google Scholar 

  31. Mortimer JE. Hormone replacement therapy and beyond. The clinical challenge of menopausal symptoms in breast cancer survivors. Geriatrics 2002;57:25–31.

    PubMed  Google Scholar 

  32. Carpenter JS, Johnson D, Wagner L, Andrykowski M. Hot flashes and related outcomes in breast cancer survivors and matched comparison women. Oncol Nurs Forum 2002;29:E16–E25.

    PubMed  Google Scholar 

  33. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results. From the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321–333; and 33a. Stefanick ML, Anderson GL, Margolis KL, Hendrix SL, Rodabough RJ, Paskett ED, Lane DS, Hubbell FA, Assaf AR, Sarto GE, Schenken RS, Yasmeen S, Lessin L, Chlebowski RT. Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy. JAMA 2006;295:1647–1657.

    Article  PubMed  CAS  Google Scholar 

  34. Pritchard KI, Khan H, Levine M. Clinical practice guidelines for the care and treatment of breast cancer: 14. The role of hormone replacement therapy in women with a previous diagnosis of breast cancer. Can Med Assoc J 2002;166:1017–1022.

    Google Scholar 

  35. Marsden J. Hormone-replacement therapy and breast cancer. Lancet Oncol 2002;3:303–311.

    Article  PubMed  Google Scholar 

  36. DiSaia PJ, Grosen EA, Kurosaki T, Gildea M, Cowan B, Anton-Culver H. Hormone replacement therapy in breast cancer survivors: a cohort study. Am J Obstet Gynecol 1996;174:1494–1498.

    Article  PubMed  CAS  Google Scholar 

  37. Decker D, Cox T, Burdakin J. Hormone replacement therapy (HRT) in breast cancer survivors. Proc Am Soc Clin Oncol 1996;15:209.

    Google Scholar 

  38. Bluming AZ, Waisman JR, Dosik GM. Hormone replacement therapy (HRT) in women with previously treated breast cancer, update IV. Proc Am Soc Clin Oncol 1998;17:496.

    Google Scholar 

  39. Powles TJ, Hickish T, Casey S, O’Brien M. Hormone replacement after breast cancer. Lancet 1993;342:60–61.

    Article  PubMed  CAS  Google Scholar 

  40. Wile AG, Opfell RW, Margileth DA. Hormone replacement therapy does not affect breast cancer outcome. Proc Am Soc Clin Oncol 1991;10:58.

    Google Scholar 

  41. Wile AG, Opfell RW, Margileth DA. Hormone replacement therapy in previously treated breast cancer patients. Am J Surg 1993;165:372–375.

    Article  PubMed  CAS  Google Scholar 

  42. Eden JA, Wren BG, Dew J. Hormone replacement therapy after breast cancer. Educational book. Alexandria (VA): American Society of Clinical Oncology, 1996:187–189.

    Google Scholar 

  43. O’Meara ES, Rossing MA, Daling JR, Elmore JG, Barlow WE, Weiss NS. Hormone replacement therapy after a diagnosis of breast cancer in relation to recurrence and mortality. J Natl Cancer Inst 2001;93:754–762.

    Article  PubMed  CAS  Google Scholar 

  44. Vassilopoulou-Sellin R, Asmar L, Hortobagyi GN, et al. Estrogen replacement therapy after localized breast cancer: clinical outcome of 319 women followed prospectively. J Clin Oncol 1999;17:1482–1487.

    PubMed  CAS  Google Scholar 

  45. Ganz PA, Greendale GA, Kahn B, O’Leary JF, Desmond KA. Are older breast carcinoma survivors willing to take hormone replacement therapy? Cancer (Phila) 1999;86:814–820.

    Article  PubMed  CAS  Google Scholar 

  46. Biglia N, Cozzarella M, Cacciari F, et al. Menopause after breast cancer: a survey on breast cancer survivors. Maturitas 2003;45:29–38.

    Article  PubMed  Google Scholar 

  47. Holmberg L, Anderson H. HABITS (hormonal replacement therapy after breast cancer-is it safe?): a randomised comparison: trial stopped. Lancet 2004;363:453–455.

    Article  PubMed  CAS  Google Scholar 

  48. Treatment of estrogen deficiency symptoms in women surviving breast cancer. Part 6: Executive summary and consensus statement. Proceedings of a conference held at Boar’s Head Inn, Charlottesville, Virginia, September 21–23, 1997. Oncology (Huntingt) 1999;13:859–861, 865–866, 871–872 passim.

    Google Scholar 

  49. Kronenberg F. Hot flashes: epidemiology and physiology. Ann N Y Acad Sci 1990;592:52–86; discussion 123–133.

    Article  PubMed  CAS  Google Scholar 

  50. Notelovitz M, Lenihan JP, McDermott M, Kerber IJ, Nanavati N, Arce J. Initial 17beta-estradiol dose for treating vasomotor symptoms. Obstet Gynecol 2000;95:726–731.

    Article  PubMed  CAS  Google Scholar 

  51. Rabin DS, Cipparrone N, Linn ES, Moen M. Why menopausal women do not want to take hormone replacement therapy. Menopause 1999;6:61–67.

    Article  PubMed  CAS  Google Scholar 

  52. Stearns V, Hayes DF. Approach to menopausal symptoms in women with breast cancer. Curr Treat Options Oncol 2002;3:179–190.

    Article  PubMed  Google Scholar 

  53. Loprinzi CL, Michalak JC, Quella SK, et al. Megestrol acetate for the prevention of hot flashes. N Engl J Med 1994;331:347–352.

    Article  PubMed  CAS  Google Scholar 

  54. Bullock JL, Massey FM, Gambrell RD Jr. Use of medroxyprogesterone acetate to prevent menopausal symptoms. Obstet Gynecol 1975;46:165–168.

    PubMed  CAS  Google Scholar 

  55. Morrison JC, Martin DC, Blair RA, et al. The use of medroxyprogesterone acetate for relief of climacteric symptoms. Am J Obstet Gynecol 1980;138:99–104.

    PubMed  CAS  Google Scholar 

  56. Schiff I, Tulchinsky D, Cramer D, Ryan KJ. Oral medroxyprogesterone in the treatment of postmenopausal symptoms. JAMA 1980;244:1443–1445.

    Article  PubMed  CAS  Google Scholar 

  57. Bertelli G, Venturini M, Del Mastro L, et al. Intramuscular depot medroxyprogesterone versus oral megestrol for the control of postmenopausal hot flashes in breast cancer patients: a randomized study. Ann Oncol 2002;13:883–888.

    Article  PubMed  CAS  Google Scholar 

  58. Guttuso T Jr, Kurlan R, McDermott MP, Kieburtz K. Gabapentin’s effects on hot flashes in postmenopausal women: a randomized controlled trial. Obstet Gynecol 2003;101:337–345.

    Article  PubMed  CAS  Google Scholar 

  59. Naessen T, Rodriguez-Macias K, Lithell H. Serum lipid profile improved by ultra-low doses of 17 beta-estradiol in elderly women. J Clin Endocrinol Metab 2001;86:2757–2762.

    Article  PubMed  CAS  Google Scholar 

  60. Ganz PA, Greendale GA, Petersen L, Zibecchi L, Kahn B, Belin TR. Managing menopausal symptoms in breast cancer survivors: results of a randomized controlled trial. J Natl Cancer Inst 2000;92:1054–1064.

    Article  PubMed  CAS  Google Scholar 

  61. Basil JB, Mutch DG. Role of hormone replacement therapy in cancer survivors. Clin Obstet Gynecol 2001;44:464–477.

    Article  PubMed  CAS  Google Scholar 

  62. Shapiro CL, Manola J, Leboff M. Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer. J Clin Oncol 2001;19:3306–3311.

    PubMed  CAS  Google Scholar 

  63. Recommended breast cancer surveillance guidelines. American Society of Clinical Oncology. J Clin Oncol 1997;15:2149–2156.

    Google Scholar 

  64. Barrett-Connor E, Bush TL. Estrogen and coronary heart disease in women. JAMA 1991;265:1861–1867.

    Article  PubMed  CAS  Google Scholar 

  65. Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE, Hennekens CH. Menopause and the risk of coronary heart disease in women. N Engl J Med 1987;316:1105–1110.

    Article  PubMed  CAS  Google Scholar 

  66. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial. JAMA 1995;273:199–208.

    Google Scholar 

  67. Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 1998;280:605–613.

    Article  PubMed  CAS  Google Scholar 

  68. Burstein HJ, Winer EP. Primary care for survivors of breast cancer. N Engl J Med 2000;343:1086–1094.

    Article  PubMed  CAS  Google Scholar 

  69. Surbone A, Petrek JA. Childbearing issues in breast carcinoma survivors. Cancer (Phila) 1997;79:1271–1278.

    Article  PubMed  CAS  Google Scholar 

  70. Collichio FA, Agnello R, Staltzer J. Pregnancy after breast cancer: from psychosocial issues through conception. Oncology (Huntingt) 1998;12:759–765, 769; discussion 770, 773–775.

    PubMed  CAS  Google Scholar 

  71. Blakely LJ, Buzdar AU, Lozada JA, et al. Effects of pregnancy after treatment for breast carcinoma on survival and risk of recurrence. Cancer (Phila) 2004;100:465–469.

    Article  PubMed  Google Scholar 

  72. Kroman N, Jensen MB, Melbye M, Wohlfahrt J, Mouridsen HT. Should women be advised against pregnancy after breast-cancer treatment? Lancet 1997;350:319–322.

    Article  PubMed  CAS  Google Scholar 

  73. Velentgas P, Daling JR, Malone KE, et al. Pregnancy after breast carcinoma: outcomes and influence on mortality. Cancer (Phila) 1999;85:2424–2432.

    Article  PubMed  CAS  Google Scholar 

  74. Sutton R, Buzdar AU, Hortobagyi GN. Pregnancy and offspring after adjuvant chemotherapy in breast cancer patients. Cancer (Phila) 1990;65:847–850.

    Article  PubMed  CAS  Google Scholar 

  75. Mulvihill JJ, McKeen EA, Rosner F, Zarrabi MH. Pregnancy outcome in cancer patients. Experience in a large cooperative group. Cancer (Phila) 1987;60:1143–1150.

    Article  PubMed  CAS  Google Scholar 

  76. Higgins S, Haffty BG. Pregnancy and lactation after breastconserving therapy for early stage breast cancer. Cancer (Phila) 1994;73:2175–2180.

    Article  PubMed  CAS  Google Scholar 

  77. Tralins AH. Lactation after conservative breast surgery combined with radiation therapy. Am J Clin Oncol 1995;18:40–43.

    Article  PubMed  CAS  Google Scholar 

  78. Moore HC, Foster RS Jr. Breast cancer and pregnancy. Semin Oncol 2000;27:646–653.

    PubMed  CAS  Google Scholar 

  79. Rosner D, Yeh J. Breast cancer and related pregnancy: suggested management according to stages of the disease and gestational stages. J Med 2002;33:23–62.

    PubMed  Google Scholar 

  80. Ganz PA, Coscarelli A, Fred C, Kahn B, Polinsky ML, Petersen L. Breast cancer survivors: psychosocial concerns and quality of life. Breast Cancer Res Treat 1996;38:183–199.

    Article  PubMed  CAS  Google Scholar 

  81. Bower JE, Ganz PA, Desmond KA, Rowland JH, Meyerowitz BE, Belin TR. Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. J Clin Oncol 2000;18:743–753.

    PubMed  CAS  Google Scholar 

  82. Andrykowski MA, Curran SL, Lightner R. Off-treatment fatigue in breast cancer survivors: a controlled comparison. J Behav Med 1998;21:1–18.

    Article  PubMed  CAS  Google Scholar 

  83. Hochster H, Wasserheit C, Speyer J. Cardiotoxicity and cardioprotection during chemotherapy. Curr Opin Oncol 1995;7:304–309.

    PubMed  CAS  Google Scholar 

  84. Steinherz LJ, Steinherz PG, Tan CT, Heller G, Murphy ML. Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA 1991;266:1672–1677.

    Article  PubMed  CAS  Google Scholar 

  85. Swain SM. Adult multicenter trials using dexrazoxane to protect against cardiac toxicity. Semin Oncol 1998;25:43–47.

    PubMed  CAS  Google Scholar 

  86. Sparano JA. Doxorubicin/taxane combinations: cardiac toxicity and pharmacokinetics. Semin Oncol 1999;3(suppl 9):14–19.

    Google Scholar 

  87. Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783–792.

    Article  PubMed  CAS  Google Scholar 

  88. Grunfeld E, Fitzpatrick R, Mant D, et al. Comparison of breast cancer patient satisfaction with follow-up in primary care versus specialist care: results from a randomized controlled trial. Br J Gen Pract 1999;49:705–710.

    PubMed  CAS  Google Scholar 

  89. Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C, Piantadosi S. The prevalence of psychological distress by cancer site. Psycho-Oncology 2001;10:19–28.

    Article  PubMed  CAS  Google Scholar 

  90. Gallagher J, Parle M, Cairns D. Appraisal and psychological distress six months after diagnosis of breast cancer. Br J Health Psychol 2002;7:365–376.

    Article  PubMed  Google Scholar 

  91. Kissane DW, Clarke DM, Ikin J, et al. Psychological morbidity and quality of life in Australian women with early-stage breast cancer: a cross-sectional survey. Med J Aust 1998;169:192–196.

    PubMed  CAS  Google Scholar 

  92. Aragona M, Muscatello MR, Mesiti M. Depressive mood disorders in patients with operable breast cancer. J Exp Clin Cancer Res 1997;16:111–118.

    PubMed  CAS  Google Scholar 

  93. Halttunen A, Hietanen P, Jallinoja P, Lonnqvist J. Getting free of breast cancer. An eight-year perspective of the relapse-free patients. Acta Oncol 1992;31:307–310.

    PubMed  CAS  Google Scholar 

  94. Fredette SL. Breast cancer survivors: concerns and coping. Cancer Nurs 1995;18:35–46.

    Article  PubMed  CAS  Google Scholar 

  95. Ferrans CE. Quality of life through the eyes of survivors of breast cancer. Oncol Nurs Forum 1994;21:1645–1651.

    PubMed  CAS  Google Scholar 

  96. Wyatt G, Kurtz ME, Liken M. Breast cancer survivors: an exploration of quality of life issues. Cancer Nurs 1993;16:440–448.

    Article  PubMed  CAS  Google Scholar 

  97. Carter BJ. Long-term survivors of breast cancer. A qualitative descriptive study. Cancer Nurs 1993;16:354–361.

    Article  PubMed  CAS  Google Scholar 

  98. Matthews BA, Baker F, Hann DM, Denniston M, Smith TG. Health status and life satisfaction among breast cancer survivor peer support volunteers. Psycho-Oncology 2002;11:199–211.

    Article  PubMed  Google Scholar 

  99. Ganz PA, Desmond KA, Leedham B, Rowland JH, Meyerowitz BE, Belin TR. Quality of life in long-term, disease-free survivors of breast cancer: a follow-up study. J Natl Cancer Inst 2002;94:39–49.

    PubMed  Google Scholar 

  100. Ganz PA, Rowland JH, Meyerowitz BE, Desmond KA. Impact of different adjuvant therapy strategies on quality of life in breast cancer survivors. Recent Results Cancer Res 1998;152:396–411.

    PubMed  CAS  Google Scholar 

  101. Tomich PL, Helgeson VS. Five years later: a cross-sectional comparison of breast cancer survivors with healthy women. Psycho-Oncology 2002;11:154–169.

    Article  PubMed  Google Scholar 

  102. Mosconi P, Apolone G, Barni S, Secondino S, Sbanotto A, Filiberti A. Quality of life in breast and colon cancer long-term survivors: an assessment with the EORTC QLQ-C30 and SF-36 questionnaires. Tumori 2002;88:110–116.

    PubMed  Google Scholar 

  103. Dorval M, Maunsell E, Deschenes L, Brisson J, Masse B. long-term quality of life after breast cancer: comparison of 8-year survivors with population controls. J Clin Oncol 1998;16:487–494.

    PubMed  CAS  Google Scholar 

  104. Brezden CB, Phillips KA, Abdolell M, Bunston T, Tannock IF. Cognitive function in breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol 2000;18:2695–2701.

    PubMed  CAS  Google Scholar 

  105. Dow KH, Ferrell BR, Leigh S, Ly J, Gulasekaram P. An evaluation of the quality of life among long-term survivors of breast cancer. Breast Cancer Res Treat 1996;39:261–273.

    Article  PubMed  CAS  Google Scholar 

  106. Ganz PA, Rowland JH, Desmond K, Meyerowitz BE, Wyatt GE. Life after breast cancer: understanding women’s health-related quality of life and sexual functioning. J Clin Oncol 1998;16:501–514.

    PubMed  CAS  Google Scholar 

  107. Kurtz ME, Wyatt G, Kurtz JC. Psychological and sexual wellbeing, philosophical/spiritual views, and health habits of long-term cancer survivors. Health Care Women Int 1995;16:253–262.

    Article  PubMed  CAS  Google Scholar 

  108. Dorval M, Maunsell E, Taylor-Brown J, Kilpatrick M. Marital stability after breast cancer. J Natl Cancer Inst 1999;91:54–59.

    Article  PubMed  CAS  Google Scholar 

  109. Wieneke MH, Dienst ER. Neuropsychological assessment of cognitive functioning following chemotherapy for breast cancer. Psycho-Oncology 1995;4:61–66.

    Article  Google Scholar 

  110. Schagen SB, van Dam FS, Muller MJ, Boogerd W, Lindeboom J, Bruning PF. Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma. Cancer (Phila) 1999;85:640–650.

    Article  PubMed  CAS  Google Scholar 

  111. van Dam FS, Schagen SB, Muller MJ, et al. Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy. J Natl Cancer Inst 1998;90:210–218.

    Article  PubMed  Google Scholar 

  112. Schagen SB, Muller MJ, Boogerd W, et al. Late effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patients. Ann Oncol 2002;13:1387–1397.

    Article  PubMed  CAS  Google Scholar 

  113. Ahles TA, Saykin AJ, Furstenberg CT, et al. Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. J Clin Oncol 2002;20:485–493.

    Article  PubMed  CAS  Google Scholar 

  114. Ferrell BR. Overview of breast cancer: quality of life. Oncology Patient Care 1993;3:7–8.

    Google Scholar 

  115. Wyatt G, Kurtz ME, Friedman LL, Given B, Given CW. Preliminary testing of the Long-Term Quality of Life (LTQL) instrument for female cancer survivors. J Nurs Meas 1996;4:153–170.

    PubMed  CAS  Google Scholar 

  116. Maunsell E, Drolet M, Brisson J, Robert J, Deschenes L. Dietary change after breast cancer: extent, predictors, and relation with psychological distress. J Clin Oncol 2002;20:1017–1025.

    Article  PubMed  Google Scholar 

  117. Burstein HJ, Gelber S, Guadagnoli E, Weeks JC. Use of alternative medicine by women with early-stage breast cancer. N Engl J Med 1999;340:1733–1739.

    Article  PubMed  CAS  Google Scholar 

  118. Lee MM, Lin SS, Wrensch MR, Adler SR, Eisenberg D. Alternative therapies used by women with breast cancer in four ethnic populations. J Natl Cancer Inst 2000;92:42–47.

    Article  PubMed  CAS  Google Scholar 

  119. Maunsell E, Brisson J, Deschenes L. Psychological distress after initial treatment for breast cancer: a comparison of partial and total mastectomy. J Clin Epidemiol 1989;42:765–771.

    Article  PubMed  CAS  Google Scholar 

  120. Vinokur AD, Threatt BA, Caplan RD, Zimmerman BL. Physical and psychosocial functioning and adjustment to breast cancer. Long-term follow-up of a screening population. Cancer (Phila) 1989;63:394–405.

    Article  PubMed  CAS  Google Scholar 

  121. Cimprich B, Ronis DL, Martinez-Ramos G. Age at diagnosis and quality of life in breast cancer survivors. Cancer Pract 2002;10:85–93.

    Article  PubMed  Google Scholar 

  122. Ganz PA, Greendale GA, Petersen L, Kahn B, Bower JE. Breast cancer in younger women: reproductive and late health effects of treatment. J Clin Oncol 2003;21:4184–4193.

    Article  PubMed  Google Scholar 

  123. Ganz PA, Guadagnoli E, Landrum MB, Lash TL, Rakowski W, Silliman RA. Breast cancer in older women: quality of life and psychosocial adjustment in the 15 months after diagnosis. J Clin Oncol 2003;21:4027–4033.

    Article  PubMed  Google Scholar 

  124. Ashing-Giwa K, Ganz PA, Petersen L. Quality of life of African-American and white long term breast carcinoma survivors. Cancer (Phila) 1999;85:418–426.

    Article  PubMed  CAS  Google Scholar 

  125. Dorval M, Maunsell E, Deschenes L, Brisson J. Type of mastectomy and quality of life for long term breast carcinoma survivors. Cancer (Phila) 1998;83:2130–2138.

    Article  PubMed  CAS  Google Scholar 

  126. Ganz PA, Schag AC, Lee JJ, Polinsky ML, Tan SJ. Breast conservation versus mastectomy. Is there a difference in psychological adjustment or quality of life in the year after surgery? Cancer (Phila) 1992;69:1729–1738.

    Article  PubMed  CAS  Google Scholar 

  127. Janni W, Rjosk D, Dimpfl TH, et al. Quality of life influenced by primary surgical treatment for stage I-III breast cancer-long-term follow-up of a matched-pair analysis. Ann Surg Oncol 2001;8:542–548.

    PubMed  CAS  Google Scholar 

  128. Omne-Ponten M, Holmberg L, Sjoden PO. Psychosocial adjustment among women with breast cancer stages I and II: six-year follow-up of consecutive patients. J Clin Oncol 1994;12:1778–1782.

    PubMed  CAS  Google Scholar 

  129. Curran D, van Dongen JP, Aaronson NK, et al. Quality of life of early-stage breast cancer patients treated with radical mastectomy or breast-conserving procedures: results of EORTC Trial 10801. The European Organization for Research and Treatment of Cancer (EORTC), Breast Cancer Co-operative Group (BCCG). Eur J Cancer 1998;34:307–314.

    Article  PubMed  CAS  Google Scholar 

  130. Schain W, Edwards BK, Gorrell CR, et al. Psychosocial and physical outcomes of primary breast cancer therapy: mastectomy vs excisional biopsy and irradiation. Breast Cancer Res Treat 1983;3:377–382.

    Article  PubMed  CAS  Google Scholar 

  131. Meyer L, Aspegren K. Long-term psychological sequelae of mastectomy and breast conserving treatment for breast cancer. Acta Oncol 1989;28:13–18.

    PubMed  CAS  Google Scholar 

  132. Omne-Ponten M, Holmberg L, Bergstrom R, Sjoden PO, Burns T. Psychosocial adjustment among husbands of women treated for breast cancer; mastectomy vs. breast-conserving surgery. Eur J Cancer 1993;29A:1393–1397.

    Article  PubMed  CAS  Google Scholar 

  133. Rowland JH, Desmond KA, Meyerowitz BE, Belin TR, Wyatt GE, Ganz PA. Role of breast reconstructive surgery in physical and emotional outcomes among breast cancer survivors. J Natl Cancer Inst 2000;92:1422–1429.

    Article  PubMed  CAS  Google Scholar 

  134. Nissen MJ, Swenson KK, Ritz LJ, Farrell JB, Sladek ML, Lally RM. Quality of life after breast carcinoma surgery: a comparison of three surgical procedures. Cancer (Phila) 2001;91:1238–1246.

    Article  PubMed  CAS  Google Scholar 

  135. Joly F, Espie M, Marty M, Heron JF, Henry-Amar M. Long-term quality of life in premenopausal women with node-negative localized breast cancer treated with or without adjuvant chemotherapy. Br J Cancer 2000;83:577–582.

    Article  PubMed  CAS  Google Scholar 

  136. Holzner B, Kemmler G, Kopp M, et al. Quality of life in breast cancer patients-not enough attention for long-term survivors? Psychosomatics 2001;42:117–123.

    Article  PubMed  CAS  Google Scholar 

  137. Kessler TA. Contextual variables, emotional state, and current and expected quality of life in breast cancer survivors. Oncol Nurs Forum 2002;29:1109–1116.

    PubMed  Google Scholar 

  138. Satariano WA, Ragheb NE, Branch LG, Swanson GM. Difficulties in physical functioning reported by middle-aged and elderly women with breast cancer: a case-control comparison. J Gerontol 1990;45:M3–M11.

    PubMed  CAS  Google Scholar 

  139. Sneeuw KC, Aaronson NK, Yarnold JR, et al. Cosmetic and functional outcomes of breast conserving treatment for early stage breast cancer. 2. Relationship with psychosocial functioning. Radiother Oncol 1992;25:160–166.

    Article  PubMed  CAS  Google Scholar 

  140. Lash TL, Silliman RA. Long-term follow-up of upper-body function among breast cancer survivors. Breast J 2002;8:28–33.

    Article  PubMed  Google Scholar 

  141. Guidozzi F. Estrogen replacement therapy in breast cancer survivors. Int J Gynaecol Obstet 1999;64:59–63.

    Article  PubMed  CAS  Google Scholar 

  142. Brewster WR, DiSaia PJ, Grosen EA, McGonigle KF, Kuykendall JL, Creasman WT. An experience with estrogen replacement therapy in breast cancer survivors. Int J Fertil Womens Med 1999;44:186–192.

    PubMed  CAS  Google Scholar 

  143. Peters GN, Fodera T, Sabol J, Jones S, Euhus D. Estrogen replacement therapy after breast cancer: a 12-year follow-up. Ann Surg Oncol 2001;8:828–832.

    Article  PubMed  CAS  Google Scholar 

  144. Durna EM, Crowe SM, Leader LR, Eden JA. Quality of life of breast cancer survivors: the impact of hormonal replacement therapy. Climacteric 2002;5:266–276.

    Article  PubMed  CAS  Google Scholar 

  145. Ellman R, Thomas BA. Is psychological wellbeing impaired in long-term survivors of breast cancer? J Med Screen 1995;2:5–9.

    PubMed  CAS  Google Scholar 

  146. Saleeba AK, Weitzner MA, Meyers CA. Subclinical psychological distress in long-term survivors of breat cancer: a preliminary communication. J Psychosocial Oncol 1996;14:83–93.

    Article  Google Scholar 

  147. Weitzner MA, Meyers CA, Stuebing KK, Saleeba AK. Relationship between quality of life and mood in long-term survivors of breast cancer treated with mastectomy. Support Care Cancer 1997;5:241–248.

    Article  PubMed  CAS  Google Scholar 

  148. Lee CO. Quality of life and breast cancer survivors. Psychosocial and treatment issues. Cancer Pract 1997;5:309–316.

    PubMed  CAS  Google Scholar 

  149. Montazeri A, Jarvandi S, Haghighat S, et al. Anxiety and depression in breast cancer patients before and after participation in a cancer support group. Patient Educ Couns 2001;45:195–198.

    Article  PubMed  CAS  Google Scholar 

  150. Mock V. Body image in women treated for breast cancer. Nurs Res 1993;42:153–157.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada

    Julie Lemieux M.D. (Attending)

  2. Department of Medical Oncology, Mount Sinai Hospital, Toronto, Ontario, Canada

    Louise J. Bordeleau M.D., F.R.C.P.(C.), M.Sc. (Attending)

  3. Department of Medicine, University of Toronto, Toronto

    Pamela J. Goodwin M.D., M.Sc., F.B.P.C. (Professor and Senior Scientist)

  4. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

    Pamela J. Goodwin M.D., M.Sc., F.B.P.C. (Professor and Senior Scientist)

Authors
  1. Julie Lemieux M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Louise J. Bordeleau M.D., F.R.C.P.(C.), M.Sc.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pamela J. Goodwin M.D., M.Sc., F.B.P.C.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Cancer Prevention and Control Research Jonsson Comprehensive Cancer Center, UCLA Schools of Public Health and Medicine, Los Angeles, CA, 90095-6900, USA

    Patricia A. Ganz M.D. (American Cancer Society Research Professor) (American Cancer Society Research Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Lemieux, J., Bordeleau, L.J., Goodwin, P.J. (2007). Medical, Psychosocial, and Health-Related Quality of Life Issues in Breast Cancer Survivors. In: Ganz, P.A. (eds) Cancer Survivorship. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68265-5_11

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-68265-5_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-34349-5

  • Online ISBN: 978-0-387-68265-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation