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References
Albertinazzi, C., Za, L., Paris, S., and de Curtis, I., 2003, ADP-ribosylation factor 6 and a functional PIX/p95–APP1 complex are required for Rac1B-mediated neurite outgrowth, Mol. Biol. Cell 14: 1295–1307.
Altschuler, Y., Liu, S., Katz, L., Tang, K., Hardy, S., Brodsky, F., et al., 1999, ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells, J. Cell Biol. 147: 7–12.
Audebert, S., Navarro, C., Nourry, C., Chasserot-Golaz, S., Lecine, P., Bellaiche, Y., et al., 2004, Mammalian Scribble forms a tight complex with the betaPIX exchange factor, Curr. Biol. 14: 987–995.
Bagrodia, S., Bailey, D., Lenard, Z., Hart, M., Guan, J.L., Premont, R.T., et al., 1999, A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21–activated kinase-binding proteins, J. Biol. Chem. 274: 22393–22400.
Beronja, S., Laprise, P., Papoulas, O., Pellikka, M., Sisson, J., and Tepass, U., 2005, Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells, J. Cell Biol. 169: 635–646.
Bloom, G.S., 2001, The UNC-104/KIF1 family of kinesins, Curr. Opin. Cell Biol. 13: 36–40.
Borisy, G.G., and Svitkina, T.M., 2000, Actin machinery: Pushing the envelope, Curr. Opin. Cell Biol. 12: 104–112.
Boshans, R.L., Szanto, S., van Aelst, L., and D'Souza-Schorey, C., 2000, ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA, Mol. Cell. Biol. 20: 3685–3694.
Botrugno, O.A., Paris, S., Za, L., Gualdoni, S., Cattaneo, A., Bachi, A., et al., 2006, Characterization of the endogenous GIT1–βPIX complex, and identification of its association to membranes, Eur. J. Cell Biol. 85: 35–46.
Bradke, F., and Dotti, C.G., 1997, Neuronal polarity: Vectorial cytoplasmic flow precedes axon formation, Neuron 19: 1175–1186.
Bretscher, M.S., 1996, Getting membrane flow and the cytoskeleton to cooperate in moving cells, Cell 87: 601–606.
Bretscher, M.S., and Aguado-Velasco, C., 1998a, EGF induces recycling membrane to form ruffles, Curr. Biol. 8: 721–724.
Bretscher, M.S., and Aguado-Velasco, C., 1998b, Membrane traffic during cell locomotion, Curr. Opin. Cell Biol. 10: 537–541.
Brown, F.D., Rozelle, A.L., Yin, H.L., Balla, T., and Donaldson, J.G., 2001, Phosphatidylinositol 4, 5–bisphosphate and Arf6–regulated membrane traffic, J. Cell Biol. 54: 1007–1017.
Cavenagh, M.M., Whitney, J.A., Carroll, K., Zhang, C., Boman, A.L., Rosenwald, A.G., et al., 1996, Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane, J. Biol. Chem. 271: 21767–21774.
Chardin, P., Paris, S., Antonny, B., Robineau, S., Beraud-Dufour, S., Jackson, C.L., et al., 1996, A human exchange factor for ARF contains Sec7–and pleckstrin-homology domains, Nature 384: 481–484.
Chavrier, P., and Goud, B., 1999, The role of ARF and Rab GTPases in membrane transport, Curr. Opin. Cell Biol. 11: 466–475.
Cheng, T.P., and Reese, T.S., 1987, Recycling of plasmalemma in chick tectal growth cones, J. Neurosci. 7: 1752–1759.
Cid-Arregui, A., Parton, R.G., Simons, K., and Dotti, C.G., 1995, Nocodazole-dependent transport, and brefeldin A-sensitive processing and sorting, of newly synthesized membrane proteins in cultured neurons, J. Neurosci. 15: 4259–4269.
Claing, A., Perry, S.J., Achiriloaie, M., Walker, J.K., Albanesi, J.P., Lefkowitz, R.J., et al., 2000, Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity, Proc. Natl. Acad. Sci. USA 97: 1119–11124.
Craig, A.M., Wyborski, R.J., and Banker, G., 1995, Preferential addition of newly synthesized membrane protein at axonal growth cones, Nature 375: 592–594.
D'Souza-Schorey, C., Li, G., Colombo, M.I., and Stahl, P.D., 1995, A regulatory role for ARF6 in receptor-mediated endocytosis, Science 267: 1175–1178.
D'Souza-Schorey, C., Boshans, R.L., McDonough, M., Stahl, P.D., and Van Aelst, L., 1997, A role for POR1, a Rac1–interacting protein, in ARF6–mediated cytoskeletal rearrangements, EMBO J. 16: 5445–5454.
D'Souza-Schorey, C., van Donselaar, E., Hsu, V.W., Yang, C., Stahl, P.D., and Peters, P.J., 1998, ARF6 targets recycling vesicles to the plasma membrane: Insights from an ultrastructural investigation, J. Cell Biol. 140: 603–616.
Dailey, M.E., and Bridgman, P.C., 1993, Vacuole dynamics in growth cones: Correlated EM and video observations, J. Neurosci. 13: 3375–3393.
Daniels, R.H., Zenke, F.T., and Bokoch, G.M., 1999, AlphaPix stimulates p21–activated kinase activity through exchange factor-dependent and -independent mechanisms, J. Biol. Chem. 274: 6047–6050.
de Curtis, I., 2001, Cell migration: GAPs between membrane traffic and the cytoskeleton, EMBO Rep. 2: 277–281.
de Hoop, M.J., Huber, L.A., Stenmark, H., Williamson, E., Zerial, M., Parton, R.G., et al., 1994, The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis, Neuron 13: 11–22.
Deretic, D., Traverso, V., Parkins, N., Jackson, F., Rodriguez de Turco, E.B., and Ransom, N., 2004, Phosphoinositides, ezrin/moesin, and rac1 regulate fusion of rhodopsin transport carriers in retinal photoreceptors, Mol. Biol. Cell 15: 359–370.
Di Cesare, A., Paris, S., Albertinazzi, C., Dariozzi, S., Andersen, J., Mann, M., et al., 2000, P95–APP1 links membrane transport to Rac-mediated reorganization of actin, Nature Cell Biol. 2: 521–530.
Diefenbach, T.J., Guthrie, P.B., Stier, H., Billups, B., and Kater, S.B., 1999, Membrane recycling in the neuronal growth cone revealed by FM1–43 labeling, J. Neurosci. 19: 9436–9444.
Donaldson, J.G., and Jackson, C.L., 2000, Regulators and effectors of the ARF GTPases, Curr. Opin. Cell Biol. 12: 475–482.
Donaldson, J.G., Kahn, R.A., Lippincott-Schwartz, J., and Klausner, R.D., 1991, Binding of ARF and beta-COP to Golgi membranes: Possible regulation by a trimeric G protein, Science 254: 1197–1199.
Donaldson, J.G., Cassel, D., Kahn, R.A., and Klausner, R.D., 1992a, ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes, Proc. Natl. Acad. Sci. USA 189: 6408–6412.
Donaldson, J.G., Finazzi, D., and Klausner, R.D., 1992b, Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein, Nature 360: 350–352.
Exton, J.H., 1997, Regulation of phosphoinositide phospholipases by G-proteins, Adv. Exp. Med. Biol. 400A: 3–8.
Finger, F.P., and Novick, P., 1998, Spatial regulation of exocytosis: Lessons from yeast, J. Cell Biol. 142: 609–612.
Franco, M., Peters, P.J., Boretto, J., van Donselaar, E., Neri, A., D'Souza-Schorey, C., et al., 1999, EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization, EMBO J. 18: 1480–1491.
Frank, S., Upender, S., Hansen, S.H., and Casanova, J.E., 1998, ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6, J. Biol. Chem. 273: 23–27.
Futerman, A.H., and Banker, G.A., 1996, The economics of neurite outgrowth-the addition of new membrane to growing axons, Trends Neurosci. 19: 144–149.
Goldberg, J., 1999, Structural and functional analysis of the ARF1–ARFGAP complex reveals a role for coatomer in GTP hydrolysis, Cell 96: 893–902.
Hall, A., 1998, Rho GTPases and the actin cytoskeleton, Science 279: 509–514.
Hao, M., and Maxfield, F.R., 2000, Characterization of rapid membrane internalization and recycling, J. Biol. Chem. 75: 15279–15286.
Helms, J.B., and Rothman, J.E., 1992, Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF, Nature 360: 352–354.
Hernandez-Deviez, D.J., Casanova, J.E., and Wilson, J.M., 2002, Regulation of dendritic development by the ARF exchange factor ARNO, Nat. Neurosci. 5: 623–624.
Hernandez-Deviez, D.J., Roth, M.G., Casanova, J.E., and Wilson, J.M., 2004, ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4–phosphate 5–kinase alpha, Mol. Biol. Cell 15: 111–120.
Hess, D.T., Smith, D.S., Patterson, S.I., Kahn, R.A., Skene, J.H., and Norden, J.J., 1999, Rapid arrest of axon elongation by brefeldin A: A role for the small GTP-binding protein ARF in neuronal growth cones, J. Neurobiol. 38: 105–115.
Honda, A., Nogami, M., Yokozeki, T., Yamazaki, M., Nakamura, M., Watanabe, H., et al., 1999, Phosphatidyl-inositol 4–phosphate 5–kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation, Cell 99: 521–532.
Hopkins, C.R., Gibson, A., Shipman, M., Strickland, D.K., and Trowbridge, I.S., 1994, In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella, J. Cell Biol. 125: 1265–1274.
Huang, J.D., Brady, S.T., Richards, B.W., Stenolen, D., Resau, J.H., Copeland, N.G., et al., 1999, Direct interaction of microtubule- and actin-based transport motors, Nature 397: 267–270.
Huber, L.A., Dupree, P., and Dotti, C.G., 1995, A deficiency of the small GTPase rab8 inhibits membrane traffic in developing neurons, Mol. Cell Biol. 15: 918–924.
Huh, M., Han, J.H., Lim, C.S., Lee, S.H., Kim, S., Kim, E., et al., 2003, Regulation of neuritogenesis and synaptic transmission by msec7–1, a guanine nucleotide exchange factor, in cultured Aplysia neurons, J. Neurochem. 85: 282–285.
Igarashi, M., Kozaki, S., Terakawa, S., Kawano, S., Ide, C., and Komiya, Y., 1996, Growth cone collapse and inhibition of neurite growth by Botulinum neurotoxin C1: A t-SNARE is involved in axonal growth, J. Cell Biol. 134: 205–215.
Jackson, C.L., and Casanova, J.E., 2000, Turning on ARF: The Sec7 family of guanine-nucleotide-exchange factors, Trends Cell Biol. 10: 60–67.
Jareb, M., and Banker, G., 1997, Inhibition of axonal growth by brefeldin A in hippocampal neurons in culture, J. Neurosci. 17: 8955–8963.
Kanaani, J., Diacovo, M.J., El-Husseini, A.-D., Bredt, D.S., and Baekkeskov, S., 2004, Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters, J. Cell Sci. 117: 2001–2013.
Kim, S., Ko, J., Shin, H., Lee, J.R., Lim, C., Han, J.H., et al., 2003, The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo, J. Biol. Chem. 278: 6291–6300.
Klausner, R.D., Donaldson, J.G., and Lippincott-Schwartz, J., 1992, Brefeldin A: Insights into the control of membrane traffic and organelle structure, J. Cell Biol. 116: 1071–1080.
Ko, J., Kim, S., Valtschanoff, J.G., Shin, H., Lee, J.R., Sheng, M., et al., 2003, Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting, J. Neurosci. 23: 1667–1677.
Krause, M., Dent, E.W., Bear, J.E., Loureiro, J.J., and Gertler, F.B., 2003, Ena/VASP proteins: Regulators of the actin cytoskeleton and cell migration, Annu. Rev. Cell Dev. Biol. 19: 541–564.
Langevin, J., Morgan, M.J., Sibarita, J.B., Aresta, S., Murthy, M., Schwarz, T., et al., 2005, Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane, Dev. Cell 9: 355–376.
Langford, G.M., 2002, Myosin-V, a versatile motor for short-range vesicle transport, Traffic 3: 859–865.
Lee, J.-R., Shin, H., Ko, J., Choi, J., Lee, H., and Kim, E., 2003, Characterization of the movement of the kinesin motor KIF1A in living cultured neurons, J. Biol. Chem. 278: 2624–2629.
Lippincott-Schwartz, J., Yuan, L., Tipper, C., Amherdt, M., Orci, L., and Klausner, R.D., 1991, Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic, Cell 67: 601–616.
Lockerbie, R.O., Miller, V.E., and Pfenninger, K.H., 1991, Regulated plasmalemmal expansion in nerve growth cones, J. Cell Biol. 112: 1215–1227.
Luo, L., 2000, Rho GTPases in neuronal morphogenesis, Nat. Rev. Neurosci. 1: 173–180.
Manser, E., Loo, T.H., Koh, C.G., Zhao, Z.S., Chen, X.Q., Tan, L., et al., 1998, PAK kinases are directly coupled to the PIX family of nucleotide exchange factors, Mol. Cell 1: 183–192.
Martenson, C., Stone, K., Reedy, M., and Sheetz, M., 1993, Fast axonal transport is required for growth cone advance, Nature 366: 66–69.
Martinez-Arca, S., Coco, S., Mainguy, G., Schenk, U., Alberts, P., Bouille, P., et al., 2001, A common exocytotic mechanism mediates axonal and dendritic outgrowth, J. Neurosci. 21: 3830–3838.
Matafora, V., Paris, S., Dariozzi, S., and de Curtis, I., 2001, Molecular mechanisms regulating the subcellular localization of p95–APP1 between the endosomal recycling compartment and sites of actin organization at the cell surface, J. Cell Sci. 114: 4509–4520.
Mazaki, Y., Hashimoto, S., Okawa, K., Tsubouchi, A., Nakamura, K., Yagi, R., et al., 2001, An ADP-ribosylation factor GTPase-activating protein Git2–short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization, Mol. Biol. Cell 12: 645–662.
Miki, H., Okada, Y., and Hirokawa, N., 2005, Analysis of the kinesin superfamily: Insights into structure and function, Trends Cell Biol. 15: 467–476.
Miller, K.E., DeProto, J., Kaufmann, N., Patel, B.N., Duckworth, A., and Van Vactor, D., 2005, Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles, Curr. Biol. 15: 684–689.
Mitchell, K.J., Doyle, J.L., Serafini, T., Kennedy, T.E., Tessier-Lavigne, M., Goodman, C.S., et al., 1996, Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons, Neuron 17: 203–215.
Morinaga, N., Tsai, S.C., Moss, J., and Vaughan, M., 1996, Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7–like domain, Proc. Natl. Acad. Sci. USA 93: 12856–12860.
Mueller, B.K., 1999, Growth cone guidance: First steps towards a deeper understanding, Annu. Rev. Neurosci. 22: 351–388.
Mundigl, O., Ochoa, G.C., David, C., Slepnev, V.I., Kabanov, A., and De Camilli, P., 1998, Amphiphysin I antisense oligonucleotides inhibit neurite outgrowth in cultured hippocampal neurons, J. Neurosci. 18: 93–103.
Murthy, M., Garza, D., Scheller, R.H., and Schwarz, T.L., 2003, Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists, Neuron 37: 433–447.
Nie, Z., Hirsch, D.S., and Randazzo, P.A., 2003, Arf and its many interactors, Curr. Opin. Cell Biol. 15: 396–404.
Nikolic, M., Chou, M.M., Lu, W., Mayer, B.J., and Tsai, L.H., 1998, The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity, Nature 395: 194–198.
Obermeier, A., Ahmed, S., Manser, E., Yen, S.C., Hall, C., and Lim, L., 1998, PAK promotes morphological changes by acting upstream of Rac, EMBO J. 17: 4328–4339.
Ohno, S., 2001, Intercellular junctions and cellular polarity: The Par-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity, Curr. Opin. Cell Biol. 13: 641–648.
Okada, Y., Yamazaki, H., Sekine-Aizawa, Y., and Hirokawa, N., 1995, The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors, Cell 81: 769–780.
Onel, S., Bolke, L., and Klambt, C., 2004, The Drosophila ARF6–GEF Schizo controls commissure formation by regulating Slit, Development 131: 2587–2594.
Paglini, G., Peris, L., Diez-Guerra, J., Quiroga, S., and Caceres, A., 2001, The Cdk5–p35 kinase associates with the Golgi apparatus and regulates membrane traffic, EMBO Rep. 2: 1139–1144.
Palacios, F., Price, L., Schweitzer, J., Collard, J.G., and D'Souza-Schorey, C., 2001, An essential role for ARF6–regulated membrane traffic in adherens junction turnover and epithelial cell migration, EMBO J. 20: 4973–4986.
Peranen, J., Auvinen, P., Virta, H., Wepf, R., and Simons, K., 1996, Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts, J. Cell Biol. 135: 153–167.
Peters, P.J., Hsu, V.W., Ooi, C.E., Finazzi, D., Teal, S.B., Oorschot, V., et al., 1995, Overexpression of wild-type and mutant ARF1 and ARF6: Distinct perturbations of nonoverlapping membrane compartments, J. Cell Biol. 128: 1003–1017.
Pfenninger, K.H., and Friedman, L.B., 1993, Sites of plasmalemmal expansion in growth cones, Dev. Brain Res. 71: 181–192.
Pfenninger, K.H., and Maylié-Pfenninger, M.-F., 1981, Lectin labeling of sprouting neurons. II. Relative movement and appearance of glycoconjugates during plasmalemmal expansion, J. Cell Biol. 89: 547–559.
Powelka, A.M., Sun, J., Li, J., Gao, M., Shaw, L.M., Sonnenberg, A., et al., 2004, Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11, Traffic 5: 20–36.
Prekeris, R., Foletti, D.L., and Scheller, R.H., 1999, Dynamics of tubulovesicular recycling endosomes in hippocampal neurons, J. Neurosci. 19: 10324–10337.
Premont, R.T., Claing, A., Vitale, N., Freeman, J.L., Pitcher, J.A., Patton, W.A., et al., 1998, Beta2–Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein, Proc. Natl. Acad. Sci. USA 95: 14082–14087.
Radhakrishna, H., and Donaldson, J.G., 1997, ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway, J. Cell Biol. 139: 49–61.
Radhakrishna, H., Klausner, R.D., and Donaldson, J.G., 1996, Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase, J. Cell Biol. 134: 935–947.
Radhakrishna, H., Al-Awar, O., Khachikian, Z., and Donaldson, J.G., 1999, ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements, J. Cell Sci. 112: 855–866.
Randazzo, P.A., Yang, Y.C., Rulka, C., and Kahn, R.A., 1993, Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A- and protease-sensitive activating factor on Golgi membranes, J. Biol. Chem. 268: 9555–9563.
Rashid, T., Banerjee, M., and Nikolic, M., 2001, Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology, J. Biol. Chem. 276: 49043–49052.
Ren, M., Xu, G., Zeng, J., De Lemos-Chiarandini, C., Adesnik, M., and Sabatini, D.D., 1998, Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes, Proc. Natl. Acad. Sci. USA 95: 6187–6192.
Rosso, S., Bollati, F., Bisbal, M., Peretti, D., Sumi, T., Nakamura, T., et al., 2004, LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons, Mol. Biol. Cell 15: 3433–3449.
Roth, M.G., 1999, Snapshots of ARF1: Implications for mechanisms of activation and inactivation, Cell 97: 149–152.
Sakagami, H., Matsuya, S., Nishimura, H., Suzuki, R., and Kondo, H., 2004, Somatodendritic localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6, in rat hippocampus and its involvement in dendritic formation, Eur. J. Neurosci. 19: 863–870.
Santy, L.C., and Casanova, J.E., 2001, Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D, J. Cell Biol. 154: 599–610.
Schoch, S., Castillo, P.E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., et al., 2002, RIM1 forms a protein scaffold for regulating neurotransmitter release at the active zone, Nature 415: 321–326.
Serafini, T., Colamarino, S.A., Leonardo, E.D., Wang, H., Beddington, R., Skarnes, W.C., et al., 1996, Netrin-1 is required for commissural axon guidance in developing vertebrate nervous system, Cell 87: 1001–1014.
Serra-Pages, C., Kedersha, N.L., Fazikas, L., Medley, Q., Debant, A., and Streuli, M., 1995, The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions, EMBO J. 14: 2827–2838.
Shapira, M., Zhai, R.G., Dresbach, T., Bresler, T., Torres, V.I., Gundelfinger, E.D., et al., 2003, Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesicles, Neuron 38: 237–252.
Shin, E.Y., Shin, K.S., Lee, C.S., Woo, K.N., Quan, S.H., Soung, N.K., et al., 2002, Phosphorylation of p85 beta PIX, a Rac/Cdc42–specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth, J. Biol. Chem. 277: 44417–44430.
Shin, H., Wyszynski, M., Huh, K.H., Valtschanoff, J.G., Lee, J.R., Ko, J., et al., 2003, Association of the kinesin motor KIF1A with the multimodular protein liprin-alpha, J. Biol. Chem. 278: 11393–11401.
Shin, H.-W., Morinaga, N., Noda, M., and Nakayama, K., 2004, BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: Its localization to recycling endosomes and implication in the endosome integrity, Mol. Biol. Cell 15: 5283–5294.
Smith, D.S., and Tsai, L.H., 2002, Cdk5 behind the wheel: A role in trafficking and transport? Trends Cell Biol. 12: 28–36.
Song, J., Khachikian, Z., Radhakrishna, H., and Donaldson, J.G., 1998, Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading, J. Cell Sci. 111: 2257–2267.
Spang, A., 2002, ARF1 regulatory factors and COPI vesicle formation, Curr. Opin. Cell Biol. 14: 423–427.
Suzuki, I., Owada, Y., Suzuki, R., Yoshimoto, T., and Kondo, H., 2001, Localization of mRNAs for six ARFs (ADP-ribosylation factors) in the brain of developing and adult rats and changes in the expression in the hypoglossal nucleus after its axotomy, Brain Res. Mol. Brain Res. 88: 124–134.
Suzuki, I., Owada, Y., Suzuki, R., Yoshimoto, T., and Kondo, H., 2002, Localization of mRNAs for subfamily of guanine nucleotide-exchange proteins (GEP) for ARFs (ADP-ribosylation factors) in the brain of developing and mature rats under normal and postaxotomy conditions, Brain Res. Mol. Brain Res. 98: 41–50.
Takai, Y., Sasaki, T., and Matozaki, T., 2001, Small GTP-Binding Proteins, Physiol. Rev. 81: 153–208.
Takeda, S., Yamazaki, H., Seog, D.H., Kanai, Y., Terada, S., and Hirokawa, N., 2000, Kinesin superfamily protein 3 (KIF3) motor transports fodrin-associating vesicles important for neurite building, J. Cell Biol. 148: 1255–1265.
Tanaka, E., and Sabry, J., 1995, Making the connection: Cytoskeletal rearrangements during growth cone guidance, Cell 83: 171–176.
Togawa, A., Morinaga, N., Ogasawara, M., Moss, J., and Vaughan, M., 1999, Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors, J. Biol. Chem. 274: 12308–12315.
Torre, E., McNiven, M.A., and Urrutia, R., 1994, Dynamin 1 antisense oligonucleotide treatment prevents neurite formation in cultured hippocampal neurons, J. Biol. Chem. 269: 32411–32417.
Tsai, S.C., Adamik, R., Moss, J., and Vaughan, M., 1996, Purification and characterization of a guanine nucleotide-exchange protein for ADP-ribosylation factor from spleen cytosol, Proc. Natl. Acad. Sci. USA 93: 305–309.
Turner, C.E., Brown, M.C., Perrotta, J.A., Riedy, M.C., Nikolopoulos, S.N., McDonald, A.R., et al., 1999, Paxillin LD4 motif binds PAK and PIX through a novel 95–kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodelling, J. Cell Biol. 145: 851–863.
Ullrich, O., Reinsch, S., Urbe, S., Zerial, M., and Parton, R.G., 1996, Rab11 regulates recycling through the pericentriolar recycling endosome, J. Cell Biol. 135: 913–924.
Ungermann, C., and Langosch, D., 2005, Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing, J. Cell Sci. 118: 3819–3828.
Vega, I.E., and Hsu, S.C., 2001, The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth, J. Neurosci. 21: 3839–3848.
Venkateswarlu, K., and Cullen, P.J., 2000, Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3–kinase, Biochem. J. 345: 719–724.
Vitale, N., Patton, W.A., Moss, J., Vaughan, M., Lefkowitz, R.J., and Premont, R.T., 2000, GIT proteins, a novel family of phosphatidylinositol 3, 4, 5–trisphosphate-stimulated GTPase-activating proteins for ARF6, J. Biol. Chem. 275: 13901–13906.
Wang, Y., Okamoto, M., Schmitz, F., Hofman, K., and Südhof, T.C., 1997, RIM is a putative Rab3A-effector in regulating synaptic vesicle fusion, Nature 388: 593–598.
Welsh, C.F., Moss, J., and Vaughan, M., 1994, Isolation of recombinant ADP-ribosylation factor 6, an approximately 20–kDa guanine nucleotide-binding protein, in an activated GTP-bound state, J. Biol. Chem. 1269: 15583–15587.
Whyte, J.R.C., and Munro, S., 2002, Vesicle tethering complexes in membrane traffic, J. Cell Sci. 115: 2627–2637.
Wu, S., Mehta, S.Q., Pichaud, F., Bellen, H.J., and Quiocho, F.A., 2005, Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo, Nat. Struct. Mol. Biol. 12: 879–885.
Wyszynski, M., Kim, E., Dunah, A.W., Passafaro, M., Valtschanoff, J.G., Serra-Pages, C., et al., 2002, Interaction Between GRIP and liprin-a/SYD2 required for AMPA receptor targeting, Neuron 34: 39–52.
Yin, H.L., and Janmey, P.A., 2003, Phosphoinositide regulation of the actin cytoskeleton, Annu. Rev. Physiol. 65: 761–789.
Yoshii, S., Tanaka, M., Otsuki, Y., Wang, D.Y., Guo, R.J., Zhu, Y., et al., 1999, AlphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3–kinase, Oncogene 18: 5680–5690.
Zakharenko, S., and Popov, S., 1998, Dynamics of axonal microtubules regulate the topology of new membrane insertion into the growing neuritis, J. Cell Biol. 143: 1077–1086.
Zerial, M., and McBride, H., 2001, Rab proteins as membrane organizers, Nat. Rev. Mol. Cell. Biol. 2: 107–117.
Zhang, Q., Cox, D., Tseng, C.C., Donaldson, J.G., and Greenberg, S., 1998, A requirement for ARF6 in Fc receptor-mediated phagocytosis in macrophages, J. Biol. Chem. 273: 19977–19981.
Zhang, H., Webb, D.J., Asmussen, H., Horwitz, A.F., 2003, Synapse formation is regulated by the signaling adaptor GIT1, J. Cell Biol. 161: 131–142.
Zhang, H., Webb, D.J., Asmussen, H., Niu, S., and Horwitz, A.F., 2005, A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC, J. Neurosci. 25: 3379–3388.
Zhang, X.M., Ellis, S., Sriratana, A., Mitchell, C.A., and Rowe, T., 2004, Sec15 is an effector for the Rab11 GTPase in mammalian cells, J. Biol. Chem. 279: 43027–43034.
Zhao, Z.S., Manser, E., Loo, T.H., and Lim, L., 2000, Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly, Mol. Cell Biol. 20: 6354–6363.
Zhen, M., and Jin, Y., 2004, Presynaptic terminal differentiation: Transport and assembly, Curr. Opin. Neurobiol. 14: 280–287.
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de Curtis, I., Corbetta, S. (2007). Small GTPases: Mechanisms Linking Membrane Traffic to Cytoskeleton During Neuritogenesis. In: de Curtis, I. (eds) Intracellular Mechanisms for Neuritogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-68561-8_4
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