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Biorelevant Dissolution Media

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Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics

Part of the book series: Biotechnology: Pharmaceutical Aspects ((PHARMASP,volume VI))

Abstract

Oral administration is the most convenient way to deliver drugs, and therefore the most preferred. However, the oral route is very complex based on the physiological conditions encountered by the drug as it passes from the mouth to the absorptive sites in the intestine. When moving from the stomach through the pylorus into the small intestine, the drug will meet a rapidly changing environment including bile and pancreatic secretions which will introduce different enzymes and surface active bile components, and increase in pH from acidic to neutral. Physiological factors such as the rate of gastric emptying, intestinal motility, blood flow, as well as volume, composition and pH of alimentary secretions are known to impact the rate and/or extent of drug absorption. The basic parameters determining the absorption of a drug compound after oral administration are its solubility and permeability in the conditions associated with the gastrointestinal (GI) tract.

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Authors and Affiliations

  1. Department of Pharmaceutics and Analytical Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen

    ANETTE MüLLERTZ

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  1. ANETTE MüLLERTZ
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  1. Catholic University of Leuven, Belgium

    Patrick Augustijns

  2. Janssen Pharmaceutica N.V., Beerse, Belgium

    Marcus E. Brewster

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MüLLERTZ, A. (2007). Biorelevant Dissolution Media. In: Augustijns, P., Brewster, M.E. (eds) Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics. Biotechnology: Pharmaceutical Aspects, vol VI. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69154-1_6

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