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The Apoptotic Mitochondrial Pathway – Modulators, Interventions and Clinical Implications

  • Chapter
Mitochondria

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 2))

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Abstract

The orderly, energy-dependent death by apoptosis is an essential process that ensures the functional and structural integrity of a variety of adult tissues and organs. This process is associated with morphological and biochemical changes, culminating in nuclear DNA fragmentation and cell shrinkage but without the dramatic disruption of the sarcolemma that is the main feature of death by necrosis (Hetts 1998). However, to ensure the safe and effective physiological role of apoptosis, a number of regulators and controllers are involved. Loss of control over apoptosis can lead to pathological conditions (e.g. proliferative disorders and degenerative conditions (reviewed in (Hetts 1998)).

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Authors
  1. M-Saadeh Suleiman
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  2. Stephen W. Schaffer
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Editors and Affiliations

  1. Department of Pharmacology, University of South Alabama, Mobile, AL, 36688-0001, USA

    Stephen W. Schaffer

  2. Bristol Royal Infirmary, Bristol, BS2 8HW, UK

    M-Saadeh Suleiman

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© 2007 Springer Science+Business Media, LLC

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Suleiman, MS., Schaffer, S.W. (2007). The Apoptotic Mitochondrial Pathway – Modulators, Interventions and Clinical Implications. In: Schaffer, S.W., Suleiman, MS. (eds) Mitochondria. Advances in Biochemistry in Health and Disease, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69945-5_12

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