Abstract
Liposomes are small vesicles consisting of one or more concentric lipid bilayers enclosing discrete aqueous spaces. Liposomes potentially serve as carriers for radiolabels to visualize pathological processes scintigraphically. Research performed during the last two decades has revealed insight on the characteristics of liposomes with regard to their tissue distribution after i.v. injection. Various approaches have been developed to radiolabel liposomes with gamma-emitting radionuclides, such as 67Ga, 111In, and 99mTc. Preferably, preformed liposomes are labeled using a so-called ‘after-loading’ method. The radionuclide can either be encapsulated in the aqueous interior or coupled to the lipid bilayer. The potential of radiolabeled liposomes to image infectious and inflammatory foci has been demonstrated in a variety of preclinical studies. In addition, two clinical studies in patients suspected of having infectious or inflammatory disease have been performed, demonstrating the potential of 99mTc-PEG-liposomes to image infection and inflammation.
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Laverman, P., Storm, G., Boerman, O.C. (2008). Use of Radiolabeled Liposomes for Imaging of Infection and Inflammation. In: Bulte, J.W., Modo, M.M. (eds) Nanoparticles in Biomedical Imaging. Fundamental Biomedical Technologies, vol 102. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72027-2_12
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DOI: https://doi.org/10.1007/978-0-387-72027-2_12
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