Abstract
In the not too distant past, there existed a mystique amongst pathologists, radiologists, and clinicians regarding neoplasms of the adrenal cortex. Specifically, there was a belief by some that it was not possible to accurately classify adrenal tumors into benign and malignant categories in the absence of metastatic disease. It was this mystical quality that led Larry Weiss and his colleagues to systematically examine the histopathology of a series of adrenocortical tumors and thus derive the evaluation system that bears his name [1, 2].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lau SK, Weiss LM (2009) The Weiss system for evaluating adrenocortical neoplasms: 25 years later. Hum Pathol 40:757–768
Weiss LM (1984) Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 8:163–169
van Slooten H et al (1985) Morphologic characteristics of benign and malignant adrenocortical tumors. Cancer 55:766–773
Giordano TJ et al (2003) Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis. Am J Pathol 162:521–531
Barlaskar FM, Hammer GD (2007) The molecular genetics of adrenocortical carcinoma. Rev Endocr Metab Disord 8:343–348
Bertherat J, Gimenez-Roqueplo AP (2005) New insights in the genetics of adrenocortical tumors, pheochromocytomas and paragangliomas. Horm Metab Res 37:384–390
Libe R, Bertherat J (2005) Molecular genetics of adrenocortical tumours, from familial to sporadic diseases. Eur J Endocrinol 153:477–487
Stratakis CA (2003) Genetics of adrenocortical tumors: gatekeepers, landscapers and conductors in symphony. Trends Endocrinol Metab 14:404–410
de Fraipont F et al (2005) Gene expression profiling of human adrenocortical tumors using complementary deoxyribonucleic acid microarrays identifies several candidate genes as markers of malignancy. J Clin Endocrinol Metab 90:1819–1829
Slater EP et al (2006) Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors. Eur J Endocrinol 154:587–598
Velazquez-Fernandez D et al (2005) Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy. Surgery 138:1087–1094
de Reynies A et al (2009) Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. J Clin Oncol 27:1108–1115
Giordano TJ et al (2009) Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin Cancer Res 15:668–676
Laurell C et al (2009) Transcriptional profiling enables molecular classification of adrenocortical tumours. Eur J Endocrinol 161:141–152
West AN et al (2007) Gene expression profiling of childhood adrenocortical tumors. Cancer Res 67:600–608
Higgins RA et al (2008) Clinical application of array-based comparative genomic hybridization for the identification of prognostically important genetic alterations in chronic lymphocytic leukemia. Mol Diagn Ther 12:271–280
Mantripragada KK et al (2004) Genomic microarrays in the spotlight. Trends Genet 20:87–94
Stephan EA et al (2008) Adrenocortical carcinoma survival rates correlated to genomic copy number variants. Mol Cancer Ther 7:425–431
Tombol Z et al (2009) Integrative molecular bioinformatics study of human adrenocortical tumors: microRNA, tissue-specific target prediction, and pathway analysis. Endocr Relat Cancer 16:895–906
Kunz M (2008) Genomic signatures for individualized treatment of malignant tumors. Curr Drug Discov Technol 5:9–14
Potti A, Nevins JR (2008) Utilization of genomic signatures to direct use of primary chemotherapy. Curr Opin Genet Dev 18:62–67
Wulfkuhle J et al (2004) Genomic and proteomic technologies for individualisation and improvement of cancer treatment. Eur J Cancer 40:2623–2632
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Giordano, T.J. (2009). Genome-Wide Studies in Adrenocortical Neoplasia. In: Hammer, G., Else, T. (eds) Adrenocortical Carcinoma. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77236-3_29
Download citation
DOI: https://doi.org/10.1007/978-0-387-77236-3_29
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-77235-6
Online ISBN: 978-0-387-77236-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)