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Early Stages of Meiosis in Wheat- and the Role of Ph1

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Genetics and Genomics of the Triticeae

Part of the book series: Plant Genetics and Genomics: Crops and Models ((PGG,volume 7))

Abstract

Studies have revealed a number of loci which control chromosome pairing and recombination in wheat. Exploitation of such loci could have a major impact on breeding strategies. The review summarises our current knowledge of this process, with particular emphasis on the most extensively studied chromosome pairing locus to date, Ph1 (Pairing homoeologous 1). The Ph1 story to date has revealed that chromatin remodeling at the start of meiosis and the control of early stages of meiotic prophase I are both important.

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References

  • Akhunov, E., Goodyear, A., Geng, S., Qi, L.-L., Echalier, B., Gill, B., Miftahudin, P., Gustafson, P., Lazo, G., Chao, S., Anderson, O., Linkiewicz, M., Dubcovsky, J., Rota, M., Sorrells, M., Zhang, D., Nguyen, H., Kalavacharla, V., Hossain, K., Kianian, S., Peng, J., Lapitan, N., Gonzalez-Hernandez, J., Anderson, J., Choi, D.-W., Close, T., Dilbirligi, M., Gill, K., Walker-Simmons, K., Steber, C., McGuire, P., Qualset, C. and Dvorak, J. (2003) The organisation and rate of evolution of wheat genomes are correlated with recombination rates along the chromosome arms. Genome Res. 13, 753–763.

    Article  PubMed  CAS  Google Scholar 

  • Al-Kaff, N., Knight, E., Bertin, I., Foot,e, T., Hart, N., Griffiths, S. and Moore, G.(2007) Detailed dissection of the chromosomal region containing the Ph1 locus in wheat Triticum aestivum L.: with deletion mutants and expression profiling. Ann. Bot. doi:10.1093/aob/mcm252.

    Google Scholar 

  • Bass, H.W., Marshall, W.F., Sedat, J.W., Agard, D.A. and Cande, W.Z. (1997) Telomere cluster de novo before the initiation of synapsis; a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. J. Cell Biol. 137, 5–18.

    Article  PubMed  CAS  Google Scholar 

  • Boden, S., Shadiac, N., Tucker, E., Langridge, P. and Able, J. (2007) Expression and functional analysis of TaAsy1 during meiosis of bread wheat Triticum aestivum. BMC Mol. Biol. 8, 65.

    Article  PubMed  Google Scholar 

  • Bowers, J.E., Chapman, B.A. Rong, J. and Paterson, A.H. (2003) Unravelling angiosperm genome evolution by phytogenetic analysis of chromosomal duplication events. Nature 422, 433–438.

    Article  PubMed  CAS  Google Scholar 

  • Chikashige, Y., Ding, D.Q., Imai, Y., Yamamoto, M., Haraguchi, T. and Hiraoka, Y. (1997) Meiotic nuclear reorganization switching the postion of centromeres and telomeres in the fission yeast. Scizaccharomyces pome. EMBO J. 16, 193–202.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, P.E., Pollack, S.E. and Pollard, J.W. (2006) Genetic analysis of chromosome pairing, recombination and cell cycle control during first meiotic prophase in mammals. Endrocine Reviews 27, 398–426.

    Article  CAS  Google Scholar 

  • Colas, I., Shaw, P., Prieto, P., Wanous, M., Spielmeyer, W., Mago, R. and Moore, G. (2008) Effective chromosome pairing requires chromatin remodelling at the onset of meiosis. Proc. Natl. Acad. Sci. USA 105, 6075–6080.

    Article  PubMed  CAS  Google Scholar 

  • Corredor, E., Lukaszewski, A., Pachon, P., Allen, D.C. and Naranjo, T. (2007) Terminal regions of wheat chromosomes select their pairing partners in meiosis. Genetics 177, 699–706.

    Article  PubMed  Google Scholar 

  • Crismani, W., Baumann, U., Sutton, T., Langridge, P. and Able, J. (2006) Microarray expression analysis of meiosis and microsporogenesis in hexaploid bread wheat. BMC Genomics 7, 267.

    Article  PubMed  Google Scholar 

  • Curtis, C.A., Lukaszewski, A.J. and Chrzastek, M. (1991) Metaphase I pairing of deficient chromosomes and genetic mapping of deficiency breakpoints in common wheat. Genome 34, 553–560.

    Article  Google Scholar 

  • Dong, C., Whitford, R. and Langridge, P. (2002) A DNA mismatch repair gene links to the Ph2 locus in wheat. Genome 45, 116–124.

    Article  PubMed  CAS  Google Scholar 

  • Dover, G.A. and Riley, R. (1972) Prevention of pairing of homeologous meiotic chromosomes of wheat by an activity of supernumerary chromosomes of Aegilops. Nature 240, 159–161.

    Article  Google Scholar 

  • Dubcovsky, J., Luo, M.-C. and Dvorak, J. (1995) Differentiation between homoeologous chromosomes 1A of wheat and 1Am of Triticum monococcum and its recognition by the wheat Ph1 locus. Proc. Natl. Acad. Sci. USA 92, 6645–6649.

    Article  PubMed  CAS  Google Scholar 

  • Dvorak, J., Deal, K.R. and Luo, M.C. (2006) Discovery and mapping of wheat Ph1 suppressor. Genetics 174, 17–27.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, M. (1966) The effect of chromosomes 5B, 5D, and 5A on chromosomal pairing in Triticum aestivum. Proc. Natl. Acad. Sci. USA 55, 1447–1453.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, M. (1993) Mode of action of Ph1 in wheat. Crop Sci. 33, 894–897.

    Article  Google Scholar 

  • Fu, H. and Dooner, H. (2002) Intraspecific violation of genetic colinearity and its implications in maize. Proc. Natl. Acad. Sci. USA 99, 9573–9578.

    PubMed  CAS  Google Scholar 

  • Griffiths, S., Sharp, R., Foote, T., Bertin, I., Wanous, M., Reader, S., Colas, I. and Moore, G. (2006) Molecular characterisation of Ph1 as a major chromosome pairing locus in polyploid wheat. Nature 439, 749–752.

    Article  PubMed  CAS  Google Scholar 

  • Hale, T.K., Contreras, L.A. Morrison, A. and Herrera, R.E. (2006) Phosphorylation of the linker Histone H1 by Cdk regulates its binding to HP1. Mol. Cell. 22, 693–699.

    Article  PubMed  CAS  Google Scholar 

  • Holm, P.B. (1986) Chromosome pairing and chiasma formation in allohexaploid wheat, Triticum aestivum, analysed by spreading of meiotic nuclei. Carlsberg Res. Commun. 51, 239–294.

    Article  Google Scholar 

  • Holm, P.B. (1988) Chromosome pairing and synaptonemal complex formation in hexaploid wheat nullisomic for chromosome 5B. Carlsberg Res. Commun. 53, 91–110.

    Article  Google Scholar 

  • Holm, P.B. and Wang, X. (1988) The effect of chromosome 5B on synapsis and chiasma formation in wheat, Triticum aestivum cv Chinese Spring. Carlsberg Res. Commun. 53, 191–208.

    Article  Google Scholar 

  • Jasencakova, Z., Meister, A. and Schubert, I. (2001) Chromatin organization and its relation to replication and histone acetylation during the cell cycle in barley. Chromosoma 110, 83–92.

    Article  PubMed  CAS  Google Scholar 

  • Jauhar, P.P., Rieva-Lizarazu, O., Dewey, W.G., Gill, B.S., Crane, C.F. and Bennett, J.H. (1991) Chromosome pairing relationships among the A,B and D genomes of bread wheat. Theor. Appl. Genet. 82, 441–449.

    Article  Google Scholar 

  • Jones, G.H. (1984) The control of chiasma distribution. Symp. Soc. Exp. Biol. 38, 293–320.

    PubMed  CAS  Google Scholar 

  • King, J., Armstead, A., Donnison, A., Roberts, L., Harper, J., Skot, K., Elborough, K. and King, I. (2007) Comparative analyses between Lolium/Festuca introgression lines and rice reveal the major fraction of functionally annotated gene models are located in recombination poor/very poor regions of the genome. Genetics 177, 547–606.

    Article  Google Scholar 

  • Korzun, I. and Kunzel, G. (1996) The physical relationship of barley chromosome 5 (1H) to the linkage group of rice chromosome 5 and 10. Mol. Gen. Genet. 252, 225–231.

    Google Scholar 

  • Kopecky, D., Allen, D.C., Duchoslav, M., Dolezel, J. and Lukaszewski, A.J. (2007) Condensation of rye chromatin in somatic interphase nuclei of Ph1 and ph1b wheat. Cytogenet Genome Res. 119, 263–267.

    Article  PubMed  CAS  Google Scholar 

  • Kunzel, G., Korzun, L. and Meister, A. (2000) Cytogenetically integrated physical restriction length polymorphism maps of the barley genome based on translocation breakpoints. Genetics 154, 397–412.

    PubMed  CAS  Google Scholar 

  • Lloyd, A.H., Milligan, A.S. Langridge, P. and Able, A. (2007) TaMSH7:A cereal mismatch repair gene that affects fertility in transgenic barley (Hordeum vulgare). 2007 BMC Plant Biology doi:10.1186/1471-2229-7-67.

    Google Scholar 

  • Luo, M.-C., Dubcovsky, J. and Dvorak, J. (1996) Recognition of homoeology by the wheat Ph1 locus. Genetics 144, 1195–1203.

    PubMed  CAS  Google Scholar 

  • Lukaszweski, A.J. (1997) The development and meiotic behaviour of asymmetrical isochromosomes in wheat. Genetics 145, 1155–1203.

    Google Scholar 

  • Maestra, B., de Jong, J.H., Shepherd, K. and Naranjo, T. (2002) Chromosome arrangement and behaviour of rye homologous telosomes at the onset of meiosis in disomic wheat 5RL addition lines with and without the Ph1 locus. Chromosome Res. 10, 655–667.

    Article  PubMed  CAS  Google Scholar 

  • Martinez, M., Cuñado, N., Carcelén, N. and Romero, C. (2001) The Ph1 and Ph2 loci play different roles in the specific behaviour of hexaploid wheat Triticum aestivum. Theor. Appl. Genet. 102, 751–758.

    Article  CAS  Google Scholar 

  • Martinez-Perez, E., Shaw, P., Reader, S., Aragon-Alcaide, L., Miller, T. and Moore, G. (1999) Homologous chromosome pairing in wheat. J. Cell Sci. 112, 1761–1769.

    PubMed  CAS  Google Scholar 

  • Martinez-Perez, E., Shaw, P. and Moore, G. (2000) Polyploidy induces centromere association. J. Cell Biol. 148, 233–238.

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Perez, E., Shaw, P. and Moore, G. (2001) The Ph1 locus is needed to ensure specific somatic and meiotic centromere association. Nature 411, 204–207.

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Perez, E., Shaw, P., Aragon, L. and Moore, G. (2003) Chromosomes form into seven groups in hexaploid and tetraploid wheat as a prelude to meiosis. Plant J. 36, 21–29.

    Article  PubMed  CAS  Google Scholar 

  • Materson, J. (2003) Stomatal size in fossil plants:Evidence of polyploidy in majority of Angiosperms. Science 264, 421–424.

    Article  Google Scholar 

  • Mikhailova, E.I., Naranjo, T., Shepherd, L., Wennekes-van Eden, J., Heyting, C. and de Jong, J.H. (1998) The effect of the wheat Ph1 locus on chromosome organization and meiotic chromosome pairing analysed by genome painting. Chromosoma 107, 339–350.

    Google Scholar 

  • Mikhailova, E.I., Sosnikhina, S.P., Kirillova, G., Tikholiz, O.A. Smirnov, V.G., Jones, R.N. and Jenkins, G. (2001) Nuclear dispositions of subtelomeric and pericentromeric chromosomal domains during meiosis in asynaptic mutants of rye (Secale cereale L). J Cell Sci. 114, 1875–1882.

    PubMed  CAS  Google Scholar 

  • Moore, G. (1995) Cereal genome evolution:pastoral pursuits with lego genomes. Curr Opin. Genet. Dev. 5, 717–724.

    Article  PubMed  CAS  Google Scholar 

  • Ortega, S., Prieto, I., Odajima, J., Martin, A., Dubus, P., Sotillo, R., Barbero, J., Malumbres, M. and Barbacid, M. (2003) Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 35, 25–31.

    Article  PubMed  CAS  Google Scholar 

  • Ozkan, H. and Feldman, M. (2001) Genotypic variation in tetraploid wheat affecting homoelogous pairing in hybrids with Aegilops peregrine. Genome 44, 1000–1006

    PubMed  CAS  Google Scholar 

  • Niwa, O., Shimanuki, M. and Mika, F. (2000) Telomere-led bouquet formation facilitates homologous chromosome pairing and restricts ectopic interaction in fission yeast meiosis. EMBO J. 19, 3831–3840.

    Article  PubMed  CAS  Google Scholar 

  • Page, S.L. and Hawley, R.S. (2003) Chromosome choreography: the meiotic ballet. Science 301, 785–789.

    Article  PubMed  CAS  Google Scholar 

  • Paux, E., Roger, D., Badaeva, E., Gay, G., Bernard, M., Sourdille, P. and Feuillet, C. (2006) Characterising the composition and evolution of homoeologous genomes in hexaploid wheat through BAC end sequencing of chromosome 3B. Plant J. 48, 463–474.

    Article  PubMed  CAS  Google Scholar 

  • Prieto, P., Shaw, P. and Moore, G. (2004) Homologue recognition during meiosis is associated with change in chromatin conformation. Nat. Cell Biol. 6, 906–908.

    Article  PubMed  CAS  Google Scholar 

  • Prieto, P., Santos, A.P., Moore, G. and Shaw, P. (2004b) Chromosomes associate premeiotically and in xylem vessel cells via their telomeres and centromeres in diploid rice (Oryza sativa). Chromosoma 112, 300–307.

    Google Scholar 

  • Prieto, P., Moore, G. and Reader, S. (2005) Control of conformation changes associated with homologue recognition during meiosis. Theor. Appl. Genet. 111, 505–510.

    Article  PubMed  Google Scholar 

  • Pryor, A., Faulkner, K., Rhoades, M.M. and Peacock, W.J. (1980) Asynchronous replication of heterochromatin in maize. Proc. Natl. Acad. Sci. USA 77, 6705–6709.

    Article  PubMed  CAS  Google Scholar 

  • Qi, L., Friebe, B., Zhang, P. and Gill, B.S. (2007) Homoeologous recombination, chromosome engineering and crop improvent. Chromosome Res. 15, 3–19

    Article  PubMed  CAS  Google Scholar 

  • Riley, R. and Chapman, V. (1958) Genetic control of the cytological diploid behaviour of hexaploid wheat. Nature 182, 712–715.

    Article  Google Scholar 

  • Roberts, M., Reader, S., Dalgliesh, C., Miller, T., Foote, T., Fish, L., Snape, J. and Moore, G. (1999) Induction and characterisation of Ph1 wheat mutants. Genetics 1999, 153, 1909–1918.

    PubMed  CAS  Google Scholar 

  • Sanchez-Moran, E., Benavonte, E. and Orellana, J. (2001) Analysis of karyotypic strability of homoeologous-pairing mutants in allopolyploid wheat. Chromosoma 110, 371–377.

    Article  PubMed  CAS  Google Scholar 

  • Scherrer, B., Isidore, E., Klein, P., Kim, J.-S., Bellec, A., Chalhoub, B., Keller, B. and Feuillet, C. (2005) Large intraspecific haplotype variability at the Rph7 locus from rapid and recent divergence in the barley genome. Plant Cell 17, 361–374.

    Article  PubMed  CAS  Google Scholar 

  • Sears, E. (1972) Agropyron-wheat transfers through induced homoeologous pairing. Can. J. Genet. Cytol. 14, 746.

    Google Scholar 

  • Sears, E. (1977) An induced mutant with homoeologous pairing in common wheat. Can. J. Genet. Cytol. 19, 585–593.

    Google Scholar 

  • Sutton, T., Whitford, R., Baurnann, U., Dong, M., Able, J. and Langridge, P. (2003) The Ph2 pairing homoeologous locus in wheat (Triticum aestivum);identification of candidate meiotic genes using a comparative genetics approach. Plant J. 36, 443–456.

    Article  PubMed  CAS  Google Scholar 

  • Tresses-Sticken, E., Dresser, M.E. and Scherthan, H. (1999) Bouquet formation in budding yeast:initiation of recombination is not required for meiotic telomere clustering. J. Cell Sci. 112, 651–658.

    Google Scholar 

  • Ward, J.O., Reinholdt, L.G., Motley, W.W., Niswander, L.M., Deacon, D.C., Griffin, L.B., Langlais, K.K., Backus, V.L., Schimenti, K.J., O’Brien, M.J., Eppig, J.J. and Schimenti, J.C. (2007) Mutation in mouse He10, an E3 Ubiquitin ligase disrupts meiotic crossing over. PLos Genetics 3:e139 doi:10.1371/journal.pgen.003011139.

    Google Scholar 

  • William, H.M., Singh, R.P., Trethowan, R., Van Ginkel, M., Pellegrinshi, A., Huerta-Espin, A. and Hosington, D. (2005) Biotechnology apllications for wheat improvement CIMMYT. Turk J. Agri. 29, 113–119.

    Google Scholar 

  • Zickler, D. and Kleckner, N. (1999) Meiotic chromosomes: integrating structures. Ann. Rev. Genet. 33, 603–754.

    Article  PubMed  CAS  Google Scholar 

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Moore, G. (2009). Early Stages of Meiosis in Wheat- and the Role of Ph1 . In: Muehlbauer, G., Feuillet, C. (eds) Genetics and Genomics of the Triticeae. Plant Genetics and Genomics: Crops and Models, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77489-3_8

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