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Cdk5/p35 Regulates Neuronal Migration

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Cyclin Dependent Kinase 5 (Cdk5)

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Abstract

Neurons migrate from proliferative zone to their final position during brain development. Cyclin-dependent kinase 5 (Cdk5) plays an important role in neuronal migration to establish a proper structure of the brain.

Analyses of Cdk5/p35-deficient mice have provided the knowledge about the role of Cdk5/p35 in neuronal migration. Over the past years, migration-related substrates of Cdk5 have been identified. Imaging analyses of neuronal migration of Cdk5/p35-deficient neurons have begun to elucidate how proper phosphorylations of these proteins by Cdk5/p35 are required for the regulation of cytoskeletal dynamics and cellular adhesion during neuronal migration.

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Authors and Affiliations

  1. Laboratory for Molecular Brain Science, Department of Life Science and Medical Bio-Science, Science and Engineering, Waseda University, Tokyo 169-8555, Japan

    Toshio Ohshima

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  1. Toshio Ohshima
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Correspondence to Toshio Ohshima .

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Editors and Affiliations

  1. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

    Nancy Y. Ip

  2. Department of Brain and Cognitive Science, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 02139, Cambridge, MA, USA

    Li-Huei Tsai

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Ohshima, T. (2008). Cdk5/p35 Regulates Neuronal Migration. In: Ip, N.Y., Tsai, LH. (eds) Cyclin Dependent Kinase 5 (Cdk5). Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78887-6_1

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