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Disseminated Intravascular Coagulation (DIC) in Cancer

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Coagulation in Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 148))

Venous thromboembolism (VTE) and disseminated intravascular coagulation (DIC) are important complications of cancer. The relationship was recognized as early as 1800 when Professor Armand Trousseau noted that patients with idiopathic VTE frequently harbor an occult cancer [1, 2]. Prandoni reported a 7.6% incidence of cancer in 145 patients following idiopathic VTE [3]. In 2000, Schulman reported that 13% of patients in his study developed cancer after their initial diagnosis of primary VTE [4]. We reported that 26.2% of veteran patients were diagnosed to have cancer within 6 months after initial VTE as compared to 11.5% of the control group [5]. These studies emphasize that there is an intimate relation between VTE and cancer.

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Authors and Affiliations

  1. Hemophilia-Hemostasis-Thrombosis Center, Department of Internal Medicine, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA

    Hussain I. Saba

  2. Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA

    Genevieve A. Morelli

  3. Section of Hematology/ Oncology, Medical Service, James A. Haley Veterans Hospital, #111R, 13000 Bruce B. Downs Blvd, Tampa, FL 33612, USA

    Rashid I. Saba

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  1. Hussain I. Saba
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    Saba, H.I., Morelli, G.A., Saba, R.I. (2009). Disseminated Intravascular Coagulation (DIC) in Cancer. In: Kwaan, H., Green, D. (eds) Coagulation in Cancer. Cancer Treatment and Research, vol 148. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-79962-9_9

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