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Dendritic Cells: From Inducers of Specific T-Cell Responses to Promoters of Angiogenesis

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Dendritic Cells in Cancer

Abstract

Dendritic cells are the most efficient antigen-presenting cells. They capture, process and present antigens to T cells, thus initiating specific immune responses. Taking into account this capability, dendritic cells have been proposed as therapeutic agents against tumors. In recent years other properties of dendritic cells have surfaced. In particular, dendritic cells have been shown to have immunosuppressive properties in some settings and were also capable of inducing proliferation of regulatory T cells. Moreover, it has been shown that dendritic cells are able to generate angiogenic factors and might be able to participate in the angiogenic process. Thus, for tumor therapeutic purposes, further studies on the biology of dendritic cells are necessary in order to generate cells with optimized immunogenic properties, but avoiding a pro-angiogenic profile.

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  1. Division of Gynecologic Oncology, Center for Research on Ovarian Cancer, University of Pennsylvania, 1209 Biomedical Research Building II/III, 421 Curie Boulevard, 19104-6142, Philadelphia, PA, USA

    George Coukos

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  1. George Coukos
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  2. Fabian Benencia
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Correspondence to George Coukos .

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    Coukos, G., Benencia, F. (2009). Dendritic Cells: From Inducers of Specific T-Cell Responses to Promoters of Angiogenesis. In: Salter, R., Shurin, M. (eds) Dendritic Cells in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-88611-4_16

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