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Non-small Cell Lung Cancer

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Handbook of Evidence-Based Radiation Oncology

Abstract

Most common noncutaneous cancer in the world. Second most common cancer in the US, behind prostate in men and breast in women. No. 1 cause of cancer death in the US and worldwide. >90% of cases are associated with smoking or involuntary smoking. Second most common cause in the US is radon. Asbestos exposure is associated with 3–4% of cases. Risk of tobacco-induced second primary is ∼2–3% per year. The surgical lymph node levels 1–9 correspond to N2 nodes, and levels 10–14 correspond to N1 nodes. 1 = high mediastinal, 2 = upper paratracheal, 3 = pre and retrotracheal, 4 = lower paratracheal, 5 = AP window, 6 = paraaortic, 7 = subcarinal, 8 = paraesophageal below carina, 9 = pulmonary ligament, 10 = hilar, 11 = interlobar, 12 = lobar, 13 = segmental, and 14 = subsegmental. Adenocarcinoma comprises 40–50% of cases. It tends to be peripherally located; it has a high propensity to metastasize (frequently to the brain).

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Authors and Affiliations

  1. Radiation Oncology, University of California San Francisco, San Francisco, CA, USA

    Siavash Jabbari MD & Daphne A. Haas-Kogan MD

  2. Radiation Oncology, The Oregon Clinic, Providence St. Vincent Medical Center, Portland, OR, US

    Eric K. Hansen MD

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  1. Div. Radiation Oncology, Oregon Clinic, SW. Barnes Rd. 9205, Portland, 97225, Oregon, USA

    Eric K. Hansen

  2. Department of Radiation Oncology, University of California, San Francisco, Divisadero Street, Suite H-1031 1600, San Francisco, 94143, California, USA

    Mack Roach

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Jabbari, S., Hansen, E.K., Haas-Kogan, D.A. (2010). Non-small Cell Lung Cancer. In: Hansen, E., Roach, M. (eds) Handbook of Evidence-Based Radiation Oncology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92988-0_15

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