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Ca2+ Ion Shifts in Vivo in Reversible and Irreversible Ischemic Injury

  • Chapter
The Ischemic Heart

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 1))

Abstract

The changes in ion content and H2O detectable in vivo in the intact canine heart in reversible and irreversible ischemic injury are described, with emphasis on the role Ca2+ movements may play in causing ischemic injury. Changes in extracellular ion concentrations and pH revealed by ion-specific electrodes in ischemia are reviewed, as are the contributions of nuclear magnetic resonance measurements of ionized Ca2+ to our understanding of Ca2+ ion homeostasis in ischemia.

During the reversible phase of ischemic injury in vivo, there is little evidence of significant failure of ion pumps. Nevertheless, substantial shifts in ions and water occur while the myocardium is ischemic. Moreover, after reperfusion with arterial blood, living reversibly injured myocytes exhibit altered volume regulation that persists for minutes to hours. Increases in intracellular Ca2+ ion are small (i.e., μM) during the reversible phase and are much larger (i.e., mM) during the irreversible phase of ischemic injury, at which time the so-called calcium overload is clearly present. It is not known whether the overload is an epiphenomenon or a primary cause of lethal injury in Ischemia and reperfusion.

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Author information

Authors and Affiliations

  1. Duke University Medical Center, USA

    Robert B. Jennings & Charles Steenbergen

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  1. Robert B. Jennings
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  2. Charles Steenbergen
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Editor information

Editors and Affiliations

  1. Department of Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Seibu Mochizuki M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda M.D., Ph.D. (Associate Professor) (Associate Professor)

  3. Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano M.D., Ph.D. (Professor-Emeritus) (Professor-Emeritus)

  4. MRC Group in Experimental Cardiology Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.), D.Sc. (Hon.) (Distinguished Professor and Director) (Distinguished Professor and Director)

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© 1998 Kluwer Academic Publishers

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Jennings, R.B., Steenbergen, C. (1998). Ca2+ Ion Shifts in Vivo in Reversible and Irreversible Ischemic Injury. In: Mochizuki, S., Takeda, N., Nagano, M., Dhalla, N.S. (eds) The Ischemic Heart. Progress in Experimental Cardiology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-39844-0_13

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  • DOI: https://doi.org/10.1007/978-0-585-39844-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-8105-1

  • Online ISBN: 978-0-585-39844-0

  • eBook Packages: Springer Book Archive

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