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Lower Extremity Cancers

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Lymphedema
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Abstract

Secondary lower limb lymphedema (LLL) is commonly associated with surgical excision of inguinofemoral lymph nodes and/or radiation of the respective node-bearing areas. The condition of LLL presents as progressive swelling of the leg(s), most typically within the first 12 months after the treatment for cancer. Once it develops, it is typically unremitting and often progressive.

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References

  1. Radhakrishnan K, Rockson SG. The clinical spectrum of lymphatic disease. Ann NY Acad Sci. 2008;1131:155-184.

    Article  PubMed  Google Scholar 

  2. Beesley V, Janda M, Eakin E, Obermair A, Battistutta D. Lymphedema after gynecological cancer treatment: prevalence, correlates, and supportive care needs. Cancer. 2007;109:2607-2614.

    Article  PubMed  Google Scholar 

  3. Ryan M, Stainton MC, Jaconelli C, Watts S, MacKenzie P, Mansberg T. The experience of lower limb lymphedema for women after treatment for gynecologic cancer. Oncol Nurs Forum. 2003;30:417-423. Online.

    Article  PubMed  Google Scholar 

  4. Schirger A. Lymphedema. Cardiovasc Clin. 1983;13:293-305.

    PubMed  CAS  Google Scholar 

  5. Lewis JM, Wald ER. Lymphedema praecox. J Pediatr. 1984;104:641-648.

    Article  PubMed  CAS  Google Scholar 

  6. Harwood CA, Bull RH, Evans J, Mortimer PS. Lymphatic and venous function in lipoedema. Br J Dermatol. 1996;134:1-6.

    Article  PubMed  CAS  Google Scholar 

  7. Wolfe JH, Kinmonth JB. The prognosis of primary lymphedema of the lower limbs. Arch Surg. 1981;116:1157-1160.

    PubMed  CAS  Google Scholar 

  8. Mortimer PS. Swollen lower limb-2: lymphoedema. BMJ. 2000;320:1527-1529.

    Article  PubMed  CAS  Google Scholar 

  9. Langbecker D, Hayes SC, Newman B, Janda M. Treatment for upper-limb and lower-limb lymphedema by professionals specializing in lymphedema care. Eur J Cancer Care (Engl). 2008;17:557-564.

    CAS  Google Scholar 

  10. Yost KJ, Yount SE, Eton DT, et al. Validation of the Functional Assessment of Cancer Therapy-Breast Symptom Index (FBSI). Breast Cancer Res Treat. 2005;90:295-298.

    Article  PubMed  Google Scholar 

  11. Tiwari A, Myint F, Hamilton G. Management of lower limb lymphoedema in the United Kingdom. Eur J Vasc Endovasc Surg. 2006;31:311-315.

    Article  PubMed  CAS  Google Scholar 

  12. Burnand K, Clemson G, Morland M, Jarrett PEM, Browese NL. Venous lipodermatosclerosis: treatment by fibrinolytic enhancement and elastic compression. Br Med J. 1980;280:7-11.

    Article  PubMed  CAS  Google Scholar 

  13. Caseley-Smith J. Measuring and representing peripheral oedema and its alterations. Lymphology. 1994;27:56-70.

    Google Scholar 

  14. Liu NF, Olszewski W. Use of tonometry to assess lower extremity lymphedema. Lymphology. 1992;25:155-158.

    PubMed  CAS  Google Scholar 

  15. Ward LC. Regarding Edema and leg volume: methods of assessment. Angiology. 2000;50:615-616.

    Article  Google Scholar 

  16. Moseley AL, Carati CJ, Piller NB. A systematic review of common conservative therapies for arm lymphoedema secondary to breast cancer treatment. Ann Oncol. 2007;18:639-646.

    Article  PubMed  CAS  Google Scholar 

  17. Hinrichs CS, Gibbs JF, Driscoll D, et al. The effectiveness of complete decongestive physiotherapy for the treatment of lymphedema following groin dissection for melanoma. J Surg Oncol. 2004;85:187-192.

    Article  PubMed  Google Scholar 

  18. Gary DE. Lymphedema diagnosis and management. J Am Acad Nurse Pract. 2007;19:72-78.

    Article  PubMed  Google Scholar 

  19. Tada H, Teramukai S, Fukushima M, Sasaki H. Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma. BMC Cancer. 2009;9:47-52.

    Article  PubMed  Google Scholar 

  20. Ryan M, Stainton MC, Slaytor EK, Jaconelli C, Watts S, Mackenzie P. Aetiology and prevalence of lower limb lymphoedema following treatment for gynaecological cancer. Aust N Z J Obstet Gynaecol. 2003;43:148-151.

    Article  PubMed  Google Scholar 

  21. Hong JH, Tsai CS, Lai CH, et al. Postoperative low-pelvic irradiation for stage I-IIA cervical cancer patients with risk factors other than pelvic lymph node metastasis. Int J Radiat Oncol Biol Phys. 2002;53:1284-1290.

    Article  PubMed  Google Scholar 

  22. Fuller J, Guderian D, Kohler C, Schneider A, Wendt TG. Lymph edema of the lower extremities after lymphadectomy and radiotherapy for cervical cancer. Strahlenther Onkol. 2008;184:206-211.

    Article  PubMed  Google Scholar 

  23. Halaska MJ, Novackova M, Mala I, et al. A prospective study of postoperative lymphedema after surgery for cervical cancer. Int J Gynecol Cancer. 2010;20:900-904.

    Article  PubMed  Google Scholar 

  24. Todo Y, Yamamoto R, Minobe S, et al. Risk factors for postoperative lower-extremity lymphedema in endometrial cancer survivors who had treatment including lymphadenectomy. Gynecol Oncol. 2010;119(1):60-64.

    Article  PubMed  Google Scholar 

  25. Abu-Rustum NR, Alektiar K, Iasonos A, et al. The incidence of symptomatic lower-extremity lymphedema following treatment of uterine corpus malignancies: a 12-year experience at Memorial Sloan-Kettering Cancer Center. Gynecol Oncol. 2006;103:714-718.

    Article  PubMed  Google Scholar 

  26. Judson P, Jonson AL, Paley PJ, et al. A prospective, randomized study analyzing sartorius transposition following inguinal-femoral lymphadenectomy. Gynecol Oncol. 2004;95:226-230.

    Article  PubMed  Google Scholar 

  27. Gaarenstroom KN, Kenter GG, Trimbos JB, et al. Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions. Int J Gynecol Cancer. 2003;13:522-527.

    Article  PubMed  CAS  Google Scholar 

  28. Amdur RJ, Parsons JT, Fitzgerald LT, Million RR. Adenocarcinoma of the prostate treated with external-beam radiation therapy: 5-year minimum follow-up. Radiother Oncol. 1990;18:235-246.

    Article  PubMed  CAS  Google Scholar 

  29. Greskovich FJ, Sagars GK, Sherman NE, Johnson DE. Complications following external beam radiation therapy for prostate cancer: an analysis of patients treated with and without staging pelvic lymphadenectomy. J Urol. 1991;146:798-802.

    PubMed  CAS  Google Scholar 

  30. Kavoussi LR, Sosa E, Chandhoke P, et al. Complications of laparoscopic pelvic lymph node dissection. J Urol. 1993;149:322-325.

    PubMed  CAS  Google Scholar 

  31. Bevan-Thomas R, Slaton JW, Pettaway CA. Contemporary morbidity from lymphadenectomy for penile squamous cell carcinoma: the M.D. Anderson Cancer Center Experience. J Urol. 2002;167:1638-1642.

    Article  PubMed  Google Scholar 

  32. Jacobellis U. Modified radical inguinal lymphadenectomy for carcinoma of the penis: technique and results. J Urol. 2003;169:1349-1352.

    Article  PubMed  Google Scholar 

  33. Ravi R. Morbidity following groin dissection for penile carcinoma. Br J Urol. 1993;72:941-945.

    Article  PubMed  CAS  Google Scholar 

  34. de Vries M, Vonkeman WG, van Ginkel RJ, Hoekstra HJ. Morbidity after inguinal sentinel lymph node biopsy and completion lymph node dissection in patients with cutaneous melanoma. Eur J Surg Oncol. 2006;32:785-789.

    Article  PubMed  Google Scholar 

  35. Ballo MT, Zagars GK, Gershenwald JE, et al. A critical assessment of adjuvant radiotherapy for inguinal lymph node metastases from melanoma. Ann Surg Oncol. 2004;11:1079-1084.

    Article  PubMed  Google Scholar 

  36. Serpell JW, Carne PW, Bailey M. Radical lymph node dissection for melanoma. ANZ J Surg. 2003;73:294-299.

    Article  PubMed  Google Scholar 

  37. Burmeister BH, Smithers BM, Davis S, et al. Radiation therapy following nodal surgery for melanoma: an analysis of late toxicity. ANZ J Surg. 2002;72:344-348.

    Article  PubMed  CAS  Google Scholar 

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Lee, MJ., Rockson, S.G. (2011). Lower Extremity Cancers. In: Lee, BB., Bergan, J., Rockson, S. (eds) Lymphedema. Springer, London. https://doi.org/10.1007/978-0-85729-567-5_61

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  • DOI: https://doi.org/10.1007/978-0-85729-567-5_61

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-566-8

  • Online ISBN: 978-0-85729-567-5

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