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What Is the Future of Immunotherapy in Ovarian Cancer?

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Controversies in the Management of Gynecological Cancers

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Abstract

Over the past several years, significant progress has been made in the treatment of gynecologic cancers. However, continued improvements to existing therapies, as well as development of novel approaches to treat these diseases, will be necessary to further reduce mortality. With increasing evidence that ovarian cancer in particular is immunogenic, there is a good reason to investigate the potential of immunotherapies. Recent success in a number of immunotherapy clinical trials targeting other tumor types has laid the groundwork necessary to begin using similar therapies against ovarian and other gynecologic cancers. Here we review past experience and future opportunities for immunotherapy in ovarian cancer, with a focus on vaccines and adoptive T-cell therapy, as well as several nonspecific immunomodulators available for immediate clinical testing.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Ovarian Cancer Research Center, Perelman School of Medicine at the University of Pennsylvania, Smilow Center for Translational Research, 8–105, 3400 Civic Center Blvd., Philadelphia, 19104, PA, USA

    Lana E. Kandalaft PharmD, PhD, MTR, Klara Balint MD, PhD & George Coukos MD, PhD

  2. Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Dr., HH333, Stanford, 94305, CA, USA

    Jonathan S. Berek MD, MMS

  3. Stanford Cancer Institute Obstetrics and Gynecology, Stanford Women’s Cancer Center, Stanford, CA, USA

    Jonathan S. Berek MD, MMS

Authors
  1. Lana E. Kandalaft PharmD, PhD, MTR
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  2. Klara Balint MD, PhD
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  3. Jonathan S. Berek MD, MMS
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  4. George Coukos MD, PhD
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Corresponding author

Correspondence to Lana E. Kandalaft PharmD, PhD, MTR .

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Editors and Affiliations

  1. UCL Cancer Institute, University College London, London, United Kingdom

    Jonathan A. Ledermann

  2. Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands

    Carien L. Creutzberg

  3. Royal Women’s Hospital, The University of Melbourne, Melbourne, Australia

    Michael A. Quinn

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Kandalaft, L.E., Balint, K., Berek, J.S., Coukos, G. (2014). What Is the Future of Immunotherapy in Ovarian Cancer?. In: Ledermann, J., Creutzberg, C., Quinn, M. (eds) Controversies in the Management of Gynecological Cancers. Springer, London. https://doi.org/10.1007/978-0-85729-910-9_29

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  • DOI: https://doi.org/10.1007/978-0-85729-910-9_29

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