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Choroid Plexus Tumors

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Role of the Choroid Plexus in Health and Disease

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

Choroid plexus tumors are rare tumors, predominantly found in pediatric patients. Lower grade tumors histologically resemble native choroid plexus while higher grade lesions are progressively more disordered and less differentiated. They are commonly associated with hydrocephalus and usually present with symptoms of that condition. Complete resection is typically curative in the case of low grade lesions. Higher grade lesions may be treated with adjuvant chemotherapy or radiotherapy. The hydrocephalus often resolves but in some cases may persist after resection and may require additional treatment.

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References

  • Abdulkader MM, Mansour NH, Van Gompel JJ, Bosh GA, Dropcho EJ, Bonnin JM et al (2016) Disseminated choroid plexus papillomas in adults: a case series and review of the literature. J Clin Neurosci 32:148–154

    Article  PubMed  Google Scholar 

  • Arasappa R, Danivas V, Venkatasubramanian G (2013) Choroid plexus papilloma presenting as schizophrenia: a case report. J Neuropsychiatry Clin Neurosci 25:E26–E27

    Article  PubMed  Google Scholar 

  • Bahar M, Hashem H, Tekautz T, Worley S, Tang A, de Blank P et al (2017) Choroid plexus tumors in adult and pediatric populations: the Cleveland Clinic and University Hospitals experience. J Neuro-Oncol 132:427–432

    Article  Google Scholar 

  • Berger C, Thiesse P, Lellouch-Tubiana A, Kalifa C, Pierre-Kahn A, Bouffet E (1998) Choroid plexus carcinomas in childhood: clinical features and prognostic factors. Neurosurgery 42:470–475

    Article  CAS  PubMed  Google Scholar 

  • Beschorner R, Waidelich J, Trautmann K, Psaras T, Schittenhelm J (2013) Notch receptors in human choroid plexus tumors. Histol Histopathol 28:1055–1063

    CAS  PubMed  Google Scholar 

  • Bettegowda C, Adogwa O, Mehta V, Chaichana KL, Weingart J, Carson BS et al (2012) Treatment of choroid plexus tumors: a 20-year single institutional experience. J Neurosurg Pediatr 10:398–405

    Article  PubMed  PubMed Central  Google Scholar 

  • Borja MJ, Plaza MJ, Altman N, Saigal G (2013) Conventional and advanced MRI features of pediatric intracranial tumors: supratentorial tumors. AJR Am J Roentgenol 200:W483–W503

    Article  PubMed  Google Scholar 

  • Bostrom A, Bostrom JP, von Lehe M, Kandenwein JA, Schramm J, Simon M (2011) Surgical treatment of choroid plexus tumors. Acta Neurochir 153:371–376

    Article  PubMed  Google Scholar 

  • Boyd MC, Steinbok P (1987) Choroid plexus tumors: problems in diagnosis and management. J Neurosurg 66:800–805

    Article  CAS  PubMed  Google Scholar 

  • Cannon DM, Mohindra P, Gondi V, Kruser TJ, Kozak KR (2015) Choroid plexus tumor epidemiology and outcomes: implications for surgical and radiotherapeutic management. J Neuro-Oncol 121:151–157

    Article  CAS  Google Scholar 

  • Chow E, Reardon DA, Shah AB, Jenkins JJ, Langston J, Heideman RL et al (1999) Pediatric choroid plexus neoplasms. Int J Radiat Oncol Biol Phys 44:249–254

    Article  CAS  PubMed  Google Scholar 

  • Dandy WE (1922) Diagnosis, localization, and removal of tumours of the third ventricle. Bull Johns Hopkins Hosp 33:188–189

    Google Scholar 

  • Dang L, Fan X, Chaudhry A, Wang M, Gaiano N, Eberhart CG (2006) Notch3 signaling initiates choroid plexus tumor formation. Oncogene 25:487–491

    Article  CAS  PubMed  Google Scholar 

  • Davis LE, Cushing H (1925) Papillomas of the choroid plexus: with the report of six cases. Arch Neurol Psychiatr 13:681–710

    Article  Google Scholar 

  • Dhillon RS, Wang YY, McKelvie PA, O’Brien B (2013) Progression of choroid plexus papilloma. J Clin Neurosci 20:1775–1778

    Article  PubMed  Google Scholar 

  • Doglietto F, Lauretti L, Tartaglione T, Gessi M, Fernandez E, Maira G (2005) Diffuse craniospinal choroid plexus papilloma with involvement of both cerebellopontine angles. Neurology 65:842

    Article  CAS  PubMed  Google Scholar 

  • Due-Tonnessen B, Helseth E, Skullerud K, Lundar T (2001) Choroid plexus tumors in children and young adults: report of 16 consecutive cases. Childs Nerv Syst 17:252–256

    Article  CAS  PubMed  Google Scholar 

  • Eisenberg HM, McComb JG, Lorenzo AV (1974) Cerebrospinal fluid overproduction and hydrocephalus associated with choroid plexus papilloma. J Neurosurg 40:381–385

    Article  CAS  PubMed  Google Scholar 

  • Ellenbogen RG, Winston KR, Kupsky WJ (1989) Tumors of the choroid plexus in children. Neurosurgery 25:327–335

    Article  CAS  PubMed  Google Scholar 

  • Gaudio RM, Tacconi L, Rossi ML (1998) Pathology of choroid plexus papillomas: a review. Clin Neurol Neurosurg 100:165–186

    Article  CAS  PubMed  Google Scholar 

  • Ghatak NR, McWhorter JM (1976) Ultrastructural evidence for CSF production by a choroid plexus papilloma. J Neurosurg 45:409–415

    Article  CAS  PubMed  Google Scholar 

  • Gopal P, Parker JR, Debski R, Parker JC Jr (2008) Choroid plexus carcinoma. Arch Pathol Lab Med 132:1350–1354

    PubMed  Google Scholar 

  • Gorelyshev SK, Matuev KB, Medvedev OA (2013) Migrating choroid plexus papilloma of the lateral ventricle in infant--modern approaches to surgical treatment. Zh Vopr Neirokhir Im N N Burdenko 77:45–49; discussion 49–50

    CAS  PubMed  Google Scholar 

  • Gozali AE, Britt B, Shane L, Gonzalez I, Gilles F, McComb JG et al (2012) Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children’s Hospital Los Angeles (CHLA) experience, 1991-2010. Pediatr Blood Cancer 58:905–909

    Article  PubMed  Google Scholar 

  • Guidetti B, Spallone A (1981) The surgical treatment of choroid plexus papillomas: the results of 27 years experience. Neurosurg Rev 4:129–137

    Article  CAS  PubMed  Google Scholar 

  • Gupta N (2003) Choroid plexus tumors in children. Neurosurg Clin N Am 14:621–631

    Article  PubMed  Google Scholar 

  • Gyure KA, Morrison AL (2000) Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. Mod Pathol 13:638–643

    Article  CAS  PubMed  Google Scholar 

  • Haliasos N, Brew S, Robertson F, Hayward R, Thompson D, Chakraborty A (2013a) Pre-operative embolisation of choroid plexus tumours in children. Part II. Observations on the effects on CSF production. Childs Nerv Syst 29:71–76

    Article  PubMed  Google Scholar 

  • Haliasos N, Brew S, Robertson F, Hayward R, Thompson D, Chakraborty A (2013b) Preoperative embolisation of choroid plexus tumours in children: Part I-Does the reduction of perioperative blood loss affect the safety of subsequent surgery? Childs Nerv Syst 29:65–70

    Article  PubMed  Google Scholar 

  • Hasselblatt M, Bohm C, Tatenhorst L, Dinh V, Newrzella D, Keyvani K et al (2006) Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. Am J Surg Pathol 30:66–74

    Article  PubMed  Google Scholar 

  • Hasselblatt M, Mertsch S, Koos B, Riesmeier B, Stegemann H, Jeibmann A et al (2009) TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion. Cancer Res 69:2219–2223

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hawkins JC 3rd (1980) Treatment of choroid plexus papillomas in children: a brief analysis of twenty years’ experience. Neurosurgery 6:380–384

    PubMed  Google Scholar 

  • Horska A, Ulug AM, Melhem ER, Filippi CG, Burger PC, Edgar MA et al (2001) Proton magnetic resonance spectroscopy of choroid plexus tumors in children. J Magn Reson Imaging 14:78–82

    Article  CAS  PubMed  Google Scholar 

  • Jagielski J, Zabek M, Wierzba-Bobrowicz T, Lakomiec B, Chrapusta SJ (2001) Disseminating histologically benign multiple papilloma of the choroid plexus: case report. Folia Neuropathol 39:209–213

    CAS  PubMed  Google Scholar 

  • Jamjoom AA, Sharab MA, Jamjoom AB, Satti MB (2009) Rapid evolution of a choroid plexus papilloma in an infant. Br J Neurosurg 23:324–325

    Article  PubMed  Google Scholar 

  • Jeibmann A, Wrede B, Peters O, Wolff JE, Paulus W, Hasselblatt M (2007) Malignant progression in choroid plexus papillomas. J Neurosurg 107:199–202

    PubMed  Google Scholar 

  • Jinhu Y, Jianping D, Jun M, Hui S, Yepeng F (2007) Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature. J Neuro-Oncol 83:47–52

    Article  Google Scholar 

  • Kahn EA, Luros JT (1952) Hydrocephalus from overproduction of cerebrospinal fluid, and experiences with other parillomas of the choroid plexus. J Neurosurg 9:59–67

    Article  CAS  PubMed  Google Scholar 

  • Karim A, Fowler M, McLaren B, Cardenas R, Patwardhan R, Nanda A (2006) Concomitant choroid plexus papillomas involving the third and fourth ventricles: a case report and review of the literature. Clin Neurol Neurosurg 108:586–589

    Article  PubMed  Google Scholar 

  • Kim TW, Jung TY, Jung S, Kim IY, Moon KS, Jeong EH (2012) Unusual radiologic findings and pathologic growth patterns on choroid plexus papillomas. J Korean Neurosurg Soc 51:272–275

    Article  PubMed  PubMed Central  Google Scholar 

  • Knierim DS (1990) Choroid plexus tumors in infants. Pediatr Neurosurg 16:276–280

    Article  PubMed  Google Scholar 

  • Koh EJ, Wang KC, Phi JH, Lee JY, Choi JW, Park SH et al (2014) Clinical outcome of pediatric choroid plexus tumors: retrospective analysis from a single institute. Childs Nerv Syst 30:217–225

    Article  PubMed  Google Scholar 

  • Koos B, Paulsson J, Jarvius M, Sanchez BC, Wrede B, Mertsch S et al (2009) Platelet-derived growth factor receptor expression and activation in choroid plexus tumors. Am J Pathol 175:1631–1637

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Krieger MD, Panigrahy A, McComb JG, Nelson MD, Liu X, Gonzalez-Gomez I et al (2005) Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. Neurosurg Focus 18:E4

    PubMed  Google Scholar 

  • Krishnan S, Brown PD, Scheithauer BW, Ebersold MJ, Hammack JE, Buckner JC (2004) Choroid plexus papillomas: a single institutional experience. J Neuro-Oncol 68:49–55

    Article  Google Scholar 

  • Laarakker AS, Nakhla J, Kobets A, Abbott R (2017) Incidental choroid plexus papilloma in a child: a difficult decision. Surg Neurol Int 8:86

    Article  PubMed  PubMed Central  Google Scholar 

  • Lafay-Cousin L, Keene D, Carret AS, Fryer C, Brossard J, Crooks B et al (2011) Choroid plexus tumors in children less than 36 months: the Canadian pediatric brain tumor consortium (CPBTC) experience. Childs Nerv Syst 27:259–264

    Article  PubMed  Google Scholar 

  • Lam S, Lin Y, Cherian J, Qadri U, Harris DA, Melkonian S et al (2013) Choroid plexus tumors in children: a population-based study. Pediatr Neurosurg 49:331–338

    Article  PubMed  Google Scholar 

  • Lechanoine F, Zemmoura I, Velut S (2017) Treating cerebrospinal fluid rhinorrhea without dura repair: a case report of posterior fossa choroid plexus papilloma and review of the literature. World Neurosurg 108:990 e991–990 e999

    Article  Google Scholar 

  • Lena G, Genitori L, Molina J, Legatte JR, Choux M (1990) Choroid plexus tumours in children. Review of 24 cases. Acta Neurochir 106:68–72

    Article  CAS  PubMed  Google Scholar 

  • Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HG et al (2016) Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol 18:418–430

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Longatti P, Basaldella L, Orvieto E, Dei Tos A, Martinuzzi A (2006) Aquaporin(s) expression in choroid plexus tumours. Pediatr Neurosurg 42:228–233

    Article  PubMed  Google Scholar 

  • Losi-Guembarovski R, Kuasne H, Guembarovski AL, Rainho CA, Colus IM (2007) DNA methylation patterns of the CDH1, RARB, and SFN genes in choroid plexus tumors. Cancer Genet Cytogenet 179:140–145

    Article  CAS  PubMed  Google Scholar 

  • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109

    Article  PubMed  PubMed Central  Google Scholar 

  • Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK et al (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803–820

    Article  PubMed  Google Scholar 

  • Mallick S, Benson R, Melgandi W, Rath GK (2017) Effect of surgery, adjuvant therapy, and other prognostic factors on choroid plexus carcinoma: a systematic review and individual patient data analysis. Int J Radiat Oncol Biol Phys 99:1199–1206

    Article  PubMed  Google Scholar 

  • Masson CB (1934) Complete removal of two tumors of the third ventricle with recovery. Arch Surg 28:527–537

    Article  Google Scholar 

  • Mazloom A, Wolff JE, Paulino AC (2010) The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma. Int J Radiat Oncol Biol Phys 78:79–84

    Article  PubMed  Google Scholar 

  • McGirr SJ, Ebersold MJ, Scheithauer BW, Quast LM, Shaw EG (1988) Choroid plexus papillomas: long-term follow-up results in a surgically treated series. J Neurosurg 69:843–849

    Article  CAS  PubMed  Google Scholar 

  • Menon G, Nair SN, Baldawa SS, Rao RB, Krishnakumar KP, Gopalakrishnan CV (2010) Choroid plexus tumors: an institutional series of 25 patients. Neurol India 58:429–435

    Article  PubMed  Google Scholar 

  • Merino DM, Shlien A, Villani A, Pienkowska M, Mack S, Ramaswamy V et al (2015) Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups. Clin Cancer Res 21:184–192

    Article  CAS  PubMed  Google Scholar 

  • Morshed RA, Lau D, Sun PP, Ostling LR (2017) Spinal drop metastasis from a benign fourth ventricular choroid plexus papilloma in a pediatric patient: case report. J Neurosurg Pediatr 20:471–479

    Article  PubMed  Google Scholar 

  • Nagib MG, O’Fallon MT (2000) Lateral ventricle choroid plexus papilloma in childhood: management and complications. Surg Neurol 54:366–372

    Article  CAS  PubMed  Google Scholar 

  • Niikawa S, Ito T, Murakawa T, Hirayama H, Ando T, Sakai N et al (1993) Recurrence of choroid plexus papilloma with malignant transformation--case report and lectin histochemistry study. Neurol Med Chir (Tokyo) 33:32–35

    Article  CAS  Google Scholar 

  • Nupponen NN, Paulsson J, Jeibmann A, Wrede B, Tanner M, Wolff JE et al (2008) Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas. Mod Pathol 21:265–270

    Article  CAS  PubMed  Google Scholar 

  • Ogiwara H, Dipatri AJ Jr, Alden TD, Bowman RM, Tomita T (2012) Choroid plexus tumors in pediatric patients. Br J Neurosurg 26:32–37

    Article  PubMed  Google Scholar 

  • Ostrom QT, Gittleman H, Liao P, Rouse C, Chen Y, Dowling J et al (2014) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro-Oncology 16(Suppl 4):iv1–i63

    Article  PubMed  PubMed Central  Google Scholar 

  • Packer RJ, Perilongo G, Johnson D, Sutton LN, Vezina G, Zimmerman RA et al (1992) Choroid plexus carcinoma of childhood. Cancer 69:580–585

    Article  CAS  PubMed  Google Scholar 

  • Pandey S, Sharma V, Singh K, Ghosh A, Gupta PK (2016) Uncommon presentation of choroid plexus papilloma in an infant. J Pediatr Neurosci 11:61–63

    Article  PubMed  PubMed Central  Google Scholar 

  • Paul L, Madan M, Rammling M, Chigurupati S, Chan SL, Pattisapu JV (2011) Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model. Neurosurgery 68:462–473

    Article  PubMed  Google Scholar 

  • Pencalet P, Sainte-Rose C, Lellouch-Tubiana A, Kalifa C, Brunelle F, Sgouros S et al (1998) Papillomas and carcinomas of the choroid plexus in children. J Neurosurg 88:521–528

    Article  CAS  PubMed  Google Scholar 

  • Peyre M, Bah A, Kalamarides M (2012) Multifocal choroid plexus papillomas: case report. Acta Neurochir 154:295–299

    Article  PubMed  Google Scholar 

  • Pianetti Filho G, Fonseca LF, da Silva MC (2002) Choroid plexus papilloma and Aicardi syndrome: case report. Arq Neuropsiquiatr 60:1008–1010

    Article  PubMed  Google Scholar 

  • Picht T, Jansons J, van Baalen A, Harder A, Pietilae TA (2006) Infant with unusually large choroid plexus papilloma undergoing emergency surgery. Case report with special emphasis on the surgical strategy. Pediatr Neurosurg 42:116–121

    Article  CAS  PubMed  Google Scholar 

  • Prendergast N, Goldstein JD, Beier AD (2018) Choroid plexus adenoma in a child: expanding the clinical and pathological spectrum. J Neurosurg Pediatr 21:428–433

    Article  PubMed  Google Scholar 

  • Safaee M, Oh MC, Bloch O, Sun MZ, Kaur G, Auguste KI et al (2013a) Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis. Neuro-Oncology 15:255–267

    Article  CAS  PubMed  Google Scholar 

  • Safaee M, Clark AJ, Bloch O, Oh MC, Singh A, Auguste KI et al (2013b) Surgical outcomes in choroid plexus papillomas: an institutional experience. J Neuro-Oncol 113:117–125

    Article  Google Scholar 

  • Salunke P, Sahoo SK, Madhivanan K, Radotra BD (2014) A typical radiological presentation in a case of choroid plexus carcinoma. Surg Neurol Int 5:63

    Article  PubMed  PubMed Central  Google Scholar 

  • Sampath S, Nitin G, Yasha TC, Chandramouli BA, Devi BI, Kovoor JM (2008) Does choroid plexus tumour differ with age? Br J Neurosurg 22:373–388

    Article  CAS  PubMed  Google Scholar 

  • Scala M, Morana G, Milanaccio C, Pavanello M, Nozza P, Garre ML (2017) Atypical choroid plexus papilloma: spontaneous resolution of diffuse leptomeningeal contrast enhancement after primary tumor removal in 2 pediatric cases. J Neurosurg Pediatr 20:284–288

    Article  PubMed  Google Scholar 

  • Scholsem M, Scholtes F, Robe PA, Bianchi E, Kroonen J, Deprez M (2012) Multifocal choroid plexus papilloma: a case report. Clin Neuropathol 31:430–434

    Article  PubMed  Google Scholar 

  • Serifoglu I, Oz II, Yazgan O, Caglar E, Guneyli S, Sunar Erdem CZ (2016) Spinal seeding of choroid plexus papilloma. Spine J 16:e421–e422

    Article  PubMed  Google Scholar 

  • Shi YZ, Chen MZ, Huang W, Guo LL, Chen X, Kong D et al (2017a) Atypical choroid plexus papilloma: clinicopathological and neuroradiological features. Acta Radiol 58:983–990

    Article  PubMed  Google Scholar 

  • Shi Y, Li X, Chen X, Xu Y, Bo G, Zhou H et al (2017b) Imaging findings of extraventricular choroid plexus papillomas: a study of 10 cases. Oncol Lett 13:1479–1485

    Article  PubMed  Google Scholar 

  • Singh P, Khan A, Scott G, Jasper M, Singh E (2017) Lesson of the month 2: a choroid plexus papilloma manifesting as anorexia nervosa in an adult. Clin Med (Lond) 17:183–185

    Article  Google Scholar 

  • Spallone A, Pastore FS, Giuffre R, Guidetti B (1990) Choroid plexus papillomas in infancy and childhood. Childs Nerv Syst 6:71–74

    Article  CAS  PubMed  Google Scholar 

  • St Clair SK, Humphreys RP, Pillay PK, Hoffman HJ, Blaser SI, Becker LE (1991) Current management of choroid plexus carcinoma in children. Pediatr Neurosurg 17:225–233

    Article  PubMed  Google Scholar 

  • Sun MZ, Oh MC, Ivan ME, Kaur G, Safaee M, Kim JM et al (2014a) Current management of choroid plexus carcinomas. Neurosurg Rev 37:179–192;. discussion 192

    Article  PubMed  Google Scholar 

  • Sun MZ, Ivan ME, Clark AJ, Oh MC, Delance AR, Oh T et al (2014b) Gross total resection improves overall survival in children with choroid plexus carcinoma. J Neuro-Oncol 116:179–185

    Article  Google Scholar 

  • Tabori U, Shlien A, Baskin B, Levitt S, Ray P, Alon N et al (2010) TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors. J Clin Oncol 28:1995–2001

    Article  CAS  PubMed  Google Scholar 

  • Tacconi L, Delfini R, Cantore G (1996) Choroid plexus papillomas: consideration of a surgical series of 33 cases. Acta Neurochir 138:802–810

    Article  CAS  PubMed  Google Scholar 

  • Taggard DA, Menezes AH (2000) Three choroid plexus papillomas in a patient with Aicardi syndrome. A case report. Pediatr Neurosurg 33:219–223

    Article  CAS  PubMed  Google Scholar 

  • Taylor MB, Jackson RW, Hughes DG, Wright NB (2001) Magnetic resonance imaging in the diagnosis and management of choroid plexus carcinoma in children. Pediatr Radiol 31:624–630

    Article  CAS  PubMed  Google Scholar 

  • Thomas C, Ruland V, Kordes U, Hartung S, Capper D, Pietsch T et al (2015) Pediatric atypical choroid plexus papilloma reconsidered: increased mitotic activity is prognostic only in older children. Acta Neuropathol 129:925–927

    Article  PubMed  Google Scholar 

  • Tong Y, Merino D, Nimmervoll B, Gupta K, Wang YD, Finkelstein D et al (2015) Cross-species genomics identifies TAF12, NFYC, and RAD54L as choroid plexus carcinoma oncogenes. Cancer Cell 27:712–727

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Trifiletti RR, Incorpora G, Polizzi A, Cocuzza MD, Bolan EA, Parano E (1995) Aicardi syndrome with multiple tumors: a case report with literature review. Brain Dev 17:283–285

    Article  CAS  PubMed  Google Scholar 

  • Unger MBE (1906) Zur kenntnis der primaren epithelgeschwulste der adergeflechte des dehirns. Arch Klin Chir 81:61–82

    Google Scholar 

  • Wind JJ, Bell RS, Bank WO, Myseros JS (2010) Treatment of third ventricular choroid plexus papilloma in an infant with embolization alone. J Neurosurg Pediatr 6:579–582

    Article  PubMed  Google Scholar 

  • Wolff JE, Sajedi M, Coppes MJ, Anderson RA, Egeler RM (1999) Radiation therapy and survival in choroid plexus carcinoma. Lancet 353:2126

    Article  CAS  PubMed  Google Scholar 

  • Wolff JE, Sajedi M, Brant R, Coppes MJ, Egeler RM (2002) Choroid plexus tumours. Br J Cancer 87:1086–1091

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wrede B, Hasselblatt M, Peters O, Thall PF, Kutluk T, Moghrabi A et al (2009) Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neuro-Oncol 95:383–392

    Article  CAS  Google Scholar 

  • Zachary G, George J, Jaishri B, Peter B, Stephanie T (2014) Management of disseminated choroid plexus papilloma: a case study. Pediatr Blood Cancer 61:562–563

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Indiana University School of Medicine, Indianapolis, IN, USA

    Daniel H. Fulkerson & Adam Leibold

  2. Beacon Children’s Hospital, Beacon Medical Group, South Bend, IN, USA

    Daniel H. Fulkerson

  3. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    David Priemer

  4. Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

    Karl Balsara

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  1. Daniel H. Fulkerson
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  2. Adam Leibold
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  4. Karl Balsara
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Correspondence to Karl Balsara .

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  1. Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus, Denmark

    Jeppe Praetorius

  2. Department of Biology, Indiana University – Purdue University Indianapolis, Indianapolis, IN, USA

    Bonnie Blazer-Yost

  3. Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus, Denmark

    Helle Damkier

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Fulkerson, D.H., Leibold, A., Priemer, D., Balsara, K. (2020). Choroid Plexus Tumors. In: Praetorius, J., Blazer-Yost, B., Damkier, H. (eds) Role of the Choroid Plexus in Health and Disease. Physiology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-0716-0536-3_10

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