Abstract
Sterigmatocystin was isolated in 1954 from Aspergillus versicolor and structurally identified in 1962.1 This mycotoxin is chemically closely related to the aflatoxins. Dickens et al.2 have shown it to be carcinogenic on subcutaneous injection in rats and Purchase and Van der Watt3 found it to be hepatocarcinogenic on oral administration. Sterigmatocystin is, however, 200 times less carcinogenic than aflatoxin B1, on subcutaneous injection in Wistar rats and 10 times less on oral administration. Holzapfel et al.4 isolated sterigmatocystin from two additional moulds: Aspergillus nidulans and Bipolaris sp. It is produced in much larger quantities than aflatoxins and although less toxic in experimental animals, it may be as hazardous to human health as aflatoxin B1.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bullock, E., Roberts, J.C. and Underwood, J.G. (1962). J. Chem. Soc. 4179.
Dickens, F., Jones, H. E. H. and Waynforth, H. B. (1966). Br. J. Cancer, 20, 134.
Purchase, I. F. H. and Van Der Watt, J. J. (1968). Fd. Cosmet. Toxicol., 6, 555.
Holzapfel, C. W., Purchase, I. F. H., Steyn, P. S. and Gouws, L. (1966). S.A. med. J., 40, 1100.
Zuckerman, A. J., Tsiquaye, K. N. and Fulton, F. (1967). Br. J. exp. Path., 48, 20.
Legator, M. (1966). Bacteriol. Rev., 30, 471.
Daniel, M. R. (1965). Brit. J. exp. Path., 46, 183.
Harley, E. H., Rees, K. R. and Cohen, A. (1969). Biochem. J., 114, 289.
Engelbrecht, J. C. and Purchase, I. F. H. (1969). S. Afr. med. J., 43, 524.
Svoboda, D., Grady, H. J. and Higginson, J. (1966). Am. J. Path., 49, 1023.
Simard, R. and Bernhard, W. (1966). Int. J. Cancer, 1, 463.
Reynolds, R. C., Montgomery, P. O’B. and Hughes, B. (1964). Cancer Res., 24, 1269.
Floyd, L. R., Unuma, T. and Busch, H. (1968). Exp. Cell. Res., 51, 423.
Lapis, K. and Bernhard, W. (1965). Cancer Res., 25, 628.
Lewin, D. K. and Moscarello, M. A. (1968). Lab. Invest., 19, 265.
Schabort, J. C. (1969). Personal communication.
Nel, W. and Pretorius, H. E. (1970). Biochem. Pharmacol., 19, 957.
Diamond, L. (1969). Progr. exp. Tumor Res., 11, 364.
Berwald, Y. and Sachs, L. (1963). Nature (Lond.), 200, 1182.
Berwald, Y. and Sachs, L. (1965). J. nat. Cancer Inst., 35, 641.
Heidelberger, C. and Iype, P. T. (1967). Science, 155, 214.
Dipaolo, J. A., Donovan, P. and Nelson, R. (1969). J. nat. Cancer Inst., 42, 867.
Alfred, L. J., Globerson, A., Berwald, Y. and Prehn, R. T. (1964). Br. J. Cancer, 18, 159.
Diamond, L. (1967). Int. J. Cancer, 2, 143.
Alfred, L. J. (1964). Br. J. Cancer, 18, 159.
Author information
Authors and Affiliations
Editor information
Copyright information
© 1971 South African Medical Research Council
About this chapter
Cite this chapter
Engelbrecht, J.C. (1971). The Effects of Aflatoxin B1 and Sterigmatocystin on Two Different Types of Cell Cultures. In: Purchase, I.F.H. (eds) Symposium on Mycotoxins in Human Health. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-01318-0_21
Download citation
DOI: https://doi.org/10.1007/978-1-349-01318-0_21
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-01320-3
Online ISBN: 978-1-349-01318-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)