Abstract
Ageing is associated with a progressive deterioration of physiological function and an increase in the variety of pathological conditions in the individual. In this paper I shall summarise the position of cell ageing studies in relation to ageing in man, indicating the particular ways in which different cell systems within the individual may become vulnerable. This is only one level at which one may consider the deterioration of function, but it is appropriate to consider it now because of recent work on cell turnover in the whole animal, on maximum cell lifespan both in vivo and in vitro and on intercellular and subcellular processes. At the subcellular level the sophistication of the genetic control of specific chemical processes is becoming apparent, and as a conclusion it will be intriguing to speculate that this plays some part at least in dictating differences in lifespan between long-lived and short-lived families and individuals.
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© 1979 J. Crooks and I. H. Stevenson
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Rowlatt, C. (1979). The pathophysiology of ageing in man: the place of the cell. In: Crooks, J., Stevenson, I.H. (eds) Drugs and the Elderly. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03813-8_4
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DOI: https://doi.org/10.1007/978-1-349-03813-8_4
Publisher Name: Palgrave Macmillan, London
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