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Prevention of Central Nervous System Leukaemia in Acute Lymphoblastic Leukaemia with Prophylactic Chemotherapy Alone

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CNS Complications of Malignant Disease

Abstract

In this report, we will bring up-to-date the results of recent clinical trials carried out at Memorial Sloan-Kettering Cancer Center with multiple drug intensive treatment regimens in children and adults with acute lymphoblastic leukaemia (ALL). In addition to attempting to improve the incidence and duration of remissions, one of the main objectives of these trials was to see if it would be possible to prevent central nervous system (CNS) leukaemia with chemotherapy alone.

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© 1979 B. D. Clarkson, M. Haghbin, M. L. Murphy, T. S. Gee, M.D. Dowling, Z. A. Arlin, S. Kempin, J. Posner, W. Shapiro, J. Galicich, P. Dufour, S. Passe and J. H. Burchenal

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Clarkson, B.D. et al. (1979). Prevention of Central Nervous System Leukaemia in Acute Lymphoblastic Leukaemia with Prophylactic Chemotherapy Alone. In: Whitehouse, J.M.A., Kay, H.E.M. (eds) CNS Complications of Malignant Disease. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04285-2_3

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  • DOI: https://doi.org/10.1007/978-1-349-04285-2_3

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-04287-6

  • Online ISBN: 978-1-349-04285-2

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