Abstract
When Curry in 1968 published his first gas chromatographic method for the determination of chlorpromazine (Curry, 1968) many expected therapeutic monitoring of this drug to be just around the corner. Since then 12 years have elapsed, characterized by an enormous advance in analytical possibilities, but without much progress when evaluated from a clinical aspect (Cooper, 1978; May and Van Putten, 1978); some possible reasons for this will be sought. The present paper is divided into two main parts: first, general considerations concerning some practical and pharmacokinetic items; second, a review of six different analytical methods, including both their advantages and problems, evaluated from a clinical point of view.
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Larsen, NE. (1981). Evaluation of existing methods for quantitation of neuroleptics in relation to clinical use. In: Usdin, E., Dahl, S.G., Gram, L.F., Lingjærde, O. (eds) Clinical Pharmacology in Psychiatry. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05929-4_1
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DOI: https://doi.org/10.1007/978-1-349-05929-4_1
Publisher Name: Palgrave Macmillan, London
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