Abstract
An alkylating agent is a compound capable of replacing a proton in another molecule by an alkyl radical. When the alkyl radical has the form RCH2—, the overall reaction may be written as follows:
Although R may be a complex, multifunctional species, and may even contain one or more aromatic rings, the final attachment of R to the substrate R’H must be through a saturated carbon atom. The alkylation reaction can occur by two extreme mechanisms.
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Wilman, D.E.V., Connors, T.A. (1983). Molecular Structure and Antitumour Activity of Alkylating Agents. In: Neidle, S., Waring, M.J. (eds) Molecular Aspects of Anti-Cancer Drug Action. Topics in Molecular and Structural Biology. Palgrave, London. https://doi.org/10.1007/978-1-349-06010-8_8
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