Abstract
The term ‘T-cell-deficient mouse’ has come to mean almost exclusively the congenitally athymic (homozygous nu/nu) or nude mouse. Nude mice are virtually completely athymic (Loor and Roelants, 1974) but may contain a few functional T cells (Rudnicka et al., 1978). Their usefulness, in a field where strain differences in parasite sensitivity are very marked, has recently been greatly enhanced by the transfer of the nu/nu genotype into several well-known inbred mouse strains.
This is a preview of subscription content, log in via an institution to check access.
Preview
Unable to display preview. Download preview PDF.
References
Allison, A. C., Christensen, J., Clark, I. A., Elford, B. C. and Eugui, E. M. (1980). The role of the spleen in protection against murine Babesia infections. In Role of the Spleen in the Immunology of Parasitic Diseases (Tropical Diseases Research Series No. 1), Schwabe, Basle, pp. 151–82
Brooks, B. O. and Reed, N. D. (1977). Thymus dependency of Trypanosoma musculi elimination from mice. J. Reticuloend. Soc., 22, 605–8
Campbell, G. H., Esser, K. M. and Phillips, S. M. (1978). Trypanosoma rhodesiense infection in congenitally athymic (nude) mice. Infect. Immun., 20, 714–20
Clark, I. A. and Allison, A. C. (1974). Babesia microti and Plasmodium berghei yoelii infections in nude mice. Nature, Lond., 252, 328
Clark, I. A., Allison, A. C. and Cox, F. E. (1976). Protection of mice against Babesia and Plasmodium with BCG. Nature, Lond., 259, 309–11
Cooper, P. G. (1980). Chemotherapy, immunology and their interactions in experimental murine trypanosomiasis. PhD Thesis, University of London
Cox, F. E. G. (1980). Human babesiosis. Nature, Lond., 285, 535–6
Doenhoff, M. J., Davies, A. J. S., Leuchars, E. and Wallis, V. (1970). The thymus and circulating lymphocytes of mice. Proc. R. Soc. Lond. (B), 176, 69–85
Doenhoff, M. and Leuchars, E. (1977). Effects of irradiation, antithymocyte serum and corticosteroids on PHA- and LPS-responsive cells of the mouse. Int. Archs Allergy appl. Immun., 53, 404–14
Eugui, E. and Allison, A. C. (1980). Differences in susceptibility of various mouse strains to haemoprotozoan infections: possible correlation with natural killer activity. Parasite Immun., 2, 277–92
Ferguson, A. and MacDonald, T. T. (1977). In Immunology of the Gut (R. Porter, and J. Knight, eds), Elsevier, Amsterdam, pp. 305ff
Irvin, A. D., Stagg, D. A., Kanhai, G. K. and Brown, C. G. D. (1975). Heterotransplantation of Theileria parva-infected cells to athymic mice. Nature, Lond., 253, 549–50
Jayawardena, A. N., Targett, G. A. T., Carter, R. L., Leuchars, E. and Davies, A. J. S. (1977a). The immunological response of CBA mice to P. yoelii. I. General characteristics, the effects of T-cell deprivation and reconstitution with thymus grants. Immunology, 32, 849–59
Jayawardena, A. N., Targett, G. A. T., Leuchars, E. and Davies, A. J. S. (1977b). The immunological response of CBA mice to P. yoelii. II. The passive transfer of immunity with serum and cells. Immunology, 34, 157–65
Jayawardena, A. N. and Waksman, B. H. (1977). Suppressor cells in experimental trypanosomiasis. Nature, Lond., 265, 539–41
Kunstryr, I., Ammerpohl, E. and Meyer, B. (1977). Experiential spironucleosis (hexamitosis) in the nude mouse as a model for immunologic and pharmacologic studies. Lab. Anim. Sci., 27, 882–8
Loor, F. and Roelants, G. E. (1974). High frequency of T-lineage lymphocytes in nude mouse spleen. Nature, Lond., 251, 229–30
Mitchell, G. F. (1977). Studies of immune responses to parasite antigen in mice. V. Different susceptibilities of hypothymic and intact mice to Babesia rodhaini. Int. Archs Allergy appl. Immun., 53, 385–8
Mitchell, G. F. (1978). Metazoan and protozoan parasitic infections in nude mice. Contemp. Topics Immunobiol., 8, 55–67
Mitchell, G. F. (1979). Responses to infection with metazoan and protozoan parasites in mice. Adv. Immun., 28, 451–511
Mitchell, G. F., Handman, E. and Howard, R. J. (1978). Protection of mice against Plasmodium and Babesia infections: attempt to raise host-protective sera. Aust. J. exp. Biol. med. Sci., 56, 553–9
Rank, R. G., Roberts, D. W. and Wiedanz, W. P. (1977). Chronic infection with Trypanosoma musculi in congenitally athymic nude mice. Infect. Immun., 16, 715–6
Roberson, E. L., Hanson, W. L. and Chapman, W. L. Jr (1973). Trypanosoma cruzi: effects of antithymocyte serum in mice and neonatal thymectomy in rats. Expl Parasit., 34, 168–80
Roberts, D. W., Rank, R. G., Wiedanz, W. P. and Finerty, J. F. (1977). Prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serum. Infect. Immun., 16, 821–6
Roberts-Thomson, I. C. and Mitchell, G. F. (1978). Giardiasis in mice. I. Prolonged infections in certain mouse strains and hypothymic (nude) mice. Gastroenterology, 75, 42–6
Roberts-Thomson, I. C. and Mitchell, G. F. (1979). Protection of mice against Giardia muris infection. Infect. Immun., 24, 971–3
Rosenberg, Y. J. and Evans, C. B. (1979). Resistance of mice suppressed for IgM production to Babesia microti infection. Nature, Lond., 281, 302–4
Rudnicka, W., Dlugonska, H., Zelazowski, P., Szeczyk, K. and Goscicka, T. (1978). Properties of antisera against lymphocytes of nude mice. Eur. J. Immun., 8, 531–4
Stevens, D. P., Frank, D. M. and Mahmoud, A. A. F. (1978). Thymus dependency of host resistance to Giardia muris infection: studies in nude mice. J. Immun., 120, 680–2
Targett, G. A. T., Leuchars, E., Davies, A. J. S. and Viens, P. (1981). Thymusgraft reconstitution of T-cell deprived mice infected with Trypanosoma musculi. Parasite Immun. (in press)
Targett, G. A. T. and Viens, P. (1975). Ablastin: control of Trypanosoma musculi infections in mice. Expl Parasit., 38, 309–16
Tawil, A. and Dusanic, D. G. (1971). The effects of antilymphocytic serum (ALS) on Trypanosoma lewisi infection. J. Parasit., 18, 445–7
Tempelis, C. H. and Lysenko, M. G. (1965). Effect of X-irradiation on Trypanosoma lewisi infection in the rat. Expl Parasit., 16, 174–81
Viens, P., Targett, G. A. T., Wilson, V. C. L. C. and Edwards, C. I. (1972). The persistence of Trypanosoma (Herpetosoma) musculi in the kidneys of immune CBA mice. Trans. R. Soc. trop. Med. Hyg., 66, 669–70
Waki, S. and Suzuki, M. (1977). Proc. International Workshop on Nude Mice, 1976
Wijesundera, M. de S. (1980). Hepatic amoebiasis in immunodepressed mice. Trans. R. Soc. trop. Med. Hyg., 74, 216–20
Wyler, D. J., Oster, C. N. and Quinn, T. C. (1980). The role of the spleen in malaria infections. In The Role of the Spleen in the Immunology of Parasitic Diseases (Tropical Diseases Research Series No. 1), Schwabe, Basle, pp. 183–204
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1982 The contributors
About this chapter
Cite this chapter
Ackers, J.P. (1982). T Cell Deprivation and the Persistence of Experimental Protozoan Infections. In: Owen, D.G. (eds) Animal Models in Parasitology. Palgrave, London. https://doi.org/10.1007/978-1-349-06136-5_11
Download citation
DOI: https://doi.org/10.1007/978-1-349-06136-5_11
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-06138-9
Online ISBN: 978-1-349-06136-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)