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The Modification of Mouse Brain Biochemistry and Wheel Running Activity Throughout the Light Period

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Circadian Rhythms in the Central Nervous System

Abstract

The mammalian pineal gland is well known to transduce environmental lighting cues into biochemical rhythms. In addition, endogenous rhythms also exist, probably controlled by the suprachiasmatic nucleus of the hypothalamus. Lesions of the suprachiasmatic nucleus disrupt biochemical and neural activity (the circadian rhythms) in rodents. In man, catecholamine excretion showed a variation during the waking period and was abolished during sleep. The present studies were undertaken to determine whether any modifications of wheel running activity and biogenic amine content in mouse brain occurs through the light period.

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© 1985 The Contributors

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Bradbury, A.J., Giddins, R.E., Smith, J.A. (1985). The Modification of Mouse Brain Biochemistry and Wheel Running Activity Throughout the Light Period. In: Redfern, P.H., Campbell, I.C., Davies, J.A., Martin, K.F. (eds) Circadian Rhythms in the Central Nervous System. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07837-0_18

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