Abstract
The signal transduction mechanisms mediating the effects of dopamine are not fully elucidated. Several pieces of evidence support the concept that activation of the dopamine D-2 receptor in the neostriatum and in the anterior pituitary gland decreases adenylate cyclase (AC) activity (Enjalbert and Bockaert, 1983; Seeman and Grigoriadis, 1987; Stoof and Kebabian, 1981; Trabucchi et al., 1975). However, in more recent experiments the stimulation of the D-2 receptor was not followed by a decrease in the cyclic AMP (cAMP) level. As an example, the inhibition of the neurotensin-induced calcium influx and prolactin release in lactotrophic cells as well as the inhibition of K+-evoked dopamine release from striatal slices, both mediated by D-2 receptor stimulation, are not accompanied by changes in the cAMP levels (Memo et al., 1986a; 1986b). These findings suggest the possibility that D-2 receptors could be linked to a second messenger generating system different from the CA. For instance recent studies with striatal tissue and cells of the anterior pituitary provided evidence that dopamine, by acting at D-2 receptor sites, inhibits both AC activity (Enjalbert et al., 1986; Stoof and Kebabian, 1981) and polyphosphoinositide (PPI) breakdown. However, in a recent study with anterior pituitary cells dopaminergic stimulation did not attenuate phosphoinositide hydrolysis (Canonico et al., 1986).
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© 1988 M. Da Prada, M. Pizzi, A. Valerio, M. Memo, P.F. Spano and W.E. Haefely
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Da Prada, M., Pizzi, M., Valerio, A., Memo, M., Spano, P.F., Haefely, W.E. (1988). Dopamine D-2 Receptor Agonists Decrease the Basal Level of Inositol 1,4,5-Trisphosphate in Rat Striatal Slices. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_11
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