Skip to main content
SpringerLink
Log in

Abortifacient Drugs

  • Chapter
Early Phase Drug Evaluation in Man

  • 42 Accesses

Abstract

Interruption of pregnancy applies to gravidae at less than 28 full weeks’ gestation with a quiescent uterus. Practically, in the overwhelming majority of cases, abortion should be performed prior to viability or at less than 22 weeks’ gestation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amy, J. J., Thiery, M., Bygdeman, M., Kerenyi, T. D., Crawford, J. S. and Karim, S. M. M. (1976). A suggested set of working definitions and criteria applicable to interruption of pregnancy. Contraception, 14, 193–7

    Article  CAS  PubMed  Google Scholar 

  • Baulieu, E. E. (1985). RU 486: An antiprogestin steroid with contragestive activity in women. In Baulieu, E. E. and Segal, S. J. (Eds.), The Antiprogestin Steroid RU 486 and Human Fertility Controls. Plenum Press, New York, pp. 1–25

    Chapter  Google Scholar 

  • Brenner, W. E. (1972). Second trimester interruption of pregnancy. In Taymor, M. K. and Green T. H. (Eds.), Progress in Gynecology, Vol. 6. Grune and Stratton, New York, pp. 421–44

    Google Scholar 

  • Brenner, W. E. (1975). The current status of prostaglandins as abortifacients. Am. J. Obstet. Gynecol., 123, 306–28

    CAS  PubMed  Google Scholar 

  • Bygdeman, M. (1978). Comparison of prostaglandin and hypertonic saline for termination of pregnancy. Obstet. Gynecol., 52, 424–9

    CAS  PubMed  Google Scholar 

  • Bygdeman, M. (1984). The use of prostaglandins and their analogues for abortion. In Newton, J. R. (Ed.), Clinics in Obstetrics and Gynaecology, Vol. 11. W. B. Saunders, London, pp. 573–84

    Google Scholar 

  • Bygdeman, M., Borell, U., Leader, A., Lundström, V., Martin, J. N., Jr., Eneroth, P. and GrĂ©en, K. (1976). Induction of first and second trimester abortion by the vaginal administration of 15-methyl PGF2α methyl ester. In Samuelsson, B. and Paoletti, R. (Eds.), Advances in Prostaglandin and Thromboxane Research, Vol. 2. Raven Press, New York, pp. 693–704

    Google Scholar 

  • Bygdeman, M., Christensen, N. J., GrĂ©en, K. and Vesterqvist, O. (1984). Seifadministration at home of prostaglandin for termination of early pregnancy. In Toppozada, M., Bygdeman, M. and Hafez, E. S. E. (Eds.), Prostaglandins and Fertility Regulation. MTP, Lancaster, pp. 83–90

    Chapter  Google Scholar 

  • Bygdeman, M. and Swahn, M. L. (1985). Progesterone receptor blockage. Effect on uterine contractility in early pregnancy. Contraception, 32, 45–51

    Article  CAS  PubMed  Google Scholar 

  • Bygdeman, M. and Van Look, P. F. A. (1988). Antiprogestins for the interruption of pregnancy. In Healy, D. L. (Ed.), Ballière’s Clinical Obstetrics and Gynaecology. Anti-hormones in Clinical Gynaecology. Ballière Tindall, London, pp. 617–29

    Google Scholar 

  • Christensen, N. J., Belfrage, P., Bygdeman, M., Floberg, J., Mitzuhashi, N. and GrĂ©en, K. (1985). Bioconversion of arachidonic acid in human pregnant uterine cervix. Acta Obstet. Gynecol. Scand., 64, 259–65

    Article  CAS  PubMed  Google Scholar 

  • Chwalisz, K., Qing, S. S., Neef, G. and Elger, W. (1987). The effect of the antigestagen ZK 98,299 on the uterine cervix. Acta Endocrinol., 283 (Suppl.), 113–14

    Google Scholar 

  • Edelman, D. A., Brenner, W. E. and Berger, G. B. (1974). Effectiveness and complication of abortion by dilatation and vacuum aspiration versus dilatation and rigid metal curettage. Am. J. Obstet. Gynecol., 119, 473–80

    CAS  PubMed  Google Scholar 

  • Galen, R. S., Chauhan, P., Wietzner, H. and Navarro, C. (1974). Fetal pathology and mechanism of fetal death in saline induced abortion: a study of 143 gestations and critical review of the literature. Am. J. Obstet. Gynecol., 12, 347–55

    Google Scholar 

  • GrĂ©en, K., Bygdeman, M. and Wiqvist, N. (1974). Kinetic and metabolic studies of prostaglandin F2α administered intra-amniotically for induction of abortion. Life Sci., 14, 2285–97

    Article  PubMed  Google Scholar 

  • GrĂ©en, K., Christensen, N. and Bygdeman, M. (1981). The chemistry and pharmacology of prostaglandins with reference to human reproduction. J. Reprod. Fertil., 62, 269–81

    Article  PubMed  Google Scholar 

  • GrĂ©en, K., Granström, E., Bygdeman, M. and Wiqvist, N. (1976). Kinetic and mrtabolic studies of 15-methyl PF2α administered intra-amniotically for induction of abortion. Prostaglandins, 11, 699–711

    Article  PubMed  Google Scholar 

  • Gustavii, B. and GrĂ©en, K. (1972). Release of prostaglandin F2α following injection of hypertonic saline for therapeutic abortion. A preliminary study. Am. J. Obstet. Gynecol., 114, 1099–100

    CAS  PubMed  Google Scholar 

  • Hulka, J. F., Leffler, H. T., Jr., Anglone, A. and Lachenbruch, P. A. (1974). A new electronic force monitor to measure factors influencing cervical dilatation for vacuum curettage. Am. J. Obstet. Gynecol., 120, 166–73

    CAS  PubMed  Google Scholar 

  • Kelly, R. W., Healy, D. L., Cameron, I. and Baird, D. T. (1986). The stimulation of prostaglandin production by two antiprogesterone steroids in human endometrial cells. J. Clin. Endocrinol. Metab., 62, 1117–23

    Google Scholar 

  • Kerenyi, T. D. (1972). Technique of late abortion. In Lewit, S. (Ed.), Abortion Techniques and Services. Excerpta Medica, Amsterdam, pp. 17–22

    Google Scholar 

  • Mandelin, M. (1978). Termination of early pregnancy by a single dose 3.0 mg 15-methyl PGF2α methyl ester vaginal suppository. Prostaglandins, 16, 143–51

    Article  CAS  PubMed  Google Scholar 

  • Newton, J., Barnard, G. and Collons, W. (1977). A rapid method for measuring blood loss using autonomic extraction. Contraception, 16, 269–82

    Article  Google Scholar 

  • Ă–lund, A. (1978). The effect of indomethacin on the instillation-abortion interval in Rivanol-induced mid-trimester abortion. Acta Obstet. Gynecol. Scand., 57, 333–6

    Article  PubMed  Google Scholar 

  • Ott, E. R. (1977). Cervical dilatation—A review. Population Reports, Series F, No. 6

    Google Scholar 

  • RĂĄdestad, A., Christensen, N. J. and Strömberg, L. (1988). Cervical ripening with Mifepristone in first trimester abortion. A double-blind randomized biomechanical study. Contraception, 38, 301–12

    Article  PubMed  Google Scholar 

  • Rodger, M. W. and Baird, D. T. (1987). Induction of therapeutic abortion in early pregnancy with mifepristone in combination with prostaglandin pessary. Lancet, ii, 1415–18

    Article  Google Scholar 

  • Rooks, J. B. and Cates, W., Jr. (1977). Emotional impact of D&E vs. instillation. Fam. Plann. Perspect., 9, 276–7

    Article  CAS  PubMed  Google Scholar 

  • RosĂ©n, A.-S., Nystedt, L., Bygdeman, M. and Lundström, V. (1979). Acceptability of a non-surgical method to terminate very early pregnancy in comparison to vacuum aspiration. Contraception, 19, 107–17

    Article  PubMed  Google Scholar 

  • RosĂ©n, A.-S., von Knorring, K., Bygdeman, M. and Christensen, N. (1984). Randomized comparison of prostaglandin treatment in hospital or at home with vacuum aspiration for termination of early pregnancy. Contraception, 29, 423–35

    Article  PubMed  Google Scholar 

  • Swahn, M. L. and Bygdeman, M. (1988). The effect of the antiprogestin RU 486 on uterine contractility and sensitivity to prostaglandin and oxytocin. Br. J. Obstet. Gynaecol., 95, 126–34

    Article  CAS  PubMed  Google Scholar 

  • Swahn, M. L., Ugocsai, G., Bygdeman, M., Kovacs, L., Belsey, E. M. and Van Look, P. F. A. (1989). Effect of oral prostaglandins E2 on uterine contractility and treatment outcome in women receiving RU 486 (mifepristone) for termination of early pregnancy. Hum. Reprod., 4, 21

    CAS  PubMed  Google Scholar 

  • Tietze, C. and Henshaw, S. K. (1986). Induced Abortion: A World Review 1986. Alan Guttmacher Institute, New York and Washington

    Google Scholar 

  • Tietze, C. and Lewit, S. (1972). Joint program for the study of gestation (JPSA). Early medical complications of legal abortion. Stud. Fam. Plann., 3, 97

    Article  Google Scholar 

  • Toppozada, M., Beguin, F., Bygdeman, M. and Wiqvist, N. (1972). Response of the midpregnant human uterus to systemic administration of 15(S)15-methyl prostaglandin F2α. Prostaglandins, 2, 239–49

    Article  CAS  PubMed  Google Scholar 

  • Uldbjerg, N., Ulmsten, U. and Ekman, G. (1987). The physiological role of eicosanoids in controlling the form and function of the cervix. In Hillier, K. (Ed.), Advances in Eicosanoid Research. MTP, Lancaster, pp. 163–83

    Chapter  Google Scholar 

  • Waltman, R., Tricorni, V. and Palay, A. (1973). Aspirin and indomethacin: Effect on instillation/abortion time of mid-trimester hypertonic saline induced abortion. Prostaglandins, 3, 47–58

    Article  CAS  PubMed  Google Scholar 

  • Van Look, P. F. A. (1989). Antiprogestin: a new era in hormonal regulation of fertility. In Proceedings of the First Congress of the International Society of Gynecological Endocrinology. Parthenon Publishing, Carnforth (in press)

    Google Scholar 

  • WHO Task Force on Post-ovulatory Methods for Fertility Regulation (1987). Menstrual regulation by intramuscular injection of 16-phenoxy-tetranor PGE2 methyl sulfonylamide or vacuum aspiration. A randomized multicenter study. Br. J. Obstet. Gynaecol., 94, 949–56

    Article  Google Scholar 

  • Zuspan, F. P., Ballard, C. A., Bieniarz, J., Brenner, W. E., Corson, S. L., Kaiser, I. H., Kerenyi, T. D., King, T. M. and Tietze, C. (1976). Second trimester abortion—a symposium by correspondence. J. Reprod. Med., 16 (2), 47–64

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept of Obstetrics and Gynaecology, Karolinska Hospital, 104 01, Stockholm, Sweden

    M. Bygdeman

Authors
  1. M. Bygdeman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. May and Baker Pharmaceuticals RhĂ´ne-Poulenc Ltd, Dagenham, RM10 7XS, UK

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  2. University of Vienna, Austria

    John O’Grady MD, FRCP (Medical Director, Visiting Professor of Clinical Pharmacology) (Medical Director, Visiting Professor of Clinical Pharmacology)

  3. Clinical Development Unit 1, The Upjohn Company, Kalamazoo, MI, 49001, USA

    Otto I. Linet MD, PhD (Director) (Director)

Copyright information

© 1990 The editors and contributors

About this chapter

Cite this chapter

Bygdeman, M. (1990). Abortifacient Drugs. In: O’Grady, J., Linet, O.I. (eds) Early Phase Drug Evaluation in Man. Palgrave, London. https://doi.org/10.1007/978-1-349-10705-6_40

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-10705-6_40

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-10707-0

  • Online ISBN: 978-1-349-10705-6

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation