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Neurotransmitters in the Dorsal Periaqueductal Grey and Animal Models of Panic Anxiety

  • Chapter
New Concepts in Anxiety

Abstract

The dorsal periaqueductal grey (DPAG) of the midbrain belongs to a longitudinally organized neural system, responsible for the behavioural and neurovegetative expression of defence reactions, like fight or flight, and for the elaboration of aversive emotional/motivational states. In addition to the DPAG, the medial hypothalamus as well as the central and dorsomedial amygdala constitute the so-called ‘brain aversive system’ (for reviews see Graeff, 1987, 1988, 1990).

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References

  • American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn (DSM-III), APA Press, Washington, DC.

    Google Scholar 

  • American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn revised (DSM-III-R), APA Press, Washington, DC.

    Google Scholar 

  • Amsterdam, J. D., Berwish, N., Potter, L. and Rickeis, K. (1987). Open trial of gepirone in the treatment of major depressive disorder. Curr. Res. Clin. Exptl., 41, 185–93.

    Google Scholar 

  • Audi, E. A. and Graeff, F. G. (1984). Benzodiazepine receptors in the periaqueductal grey mediate anti-aversive drug action. Eur. J. Pharmacol., 103, 279–85.

    Article  PubMed  CAS  Google Scholar 

  • Audi, E. A. and Graeff, F. G. (1987). GABAA receptors in the midbrain central grey mediate the antiaversive action of GABA. Eur. J. Pharmacol., 135, 225–9.

    Article  PubMed  CAS  Google Scholar 

  • Audi, E. A., de Aguiar, J. C. and Graeff, F. G. (1988). Mediation by serotonin of the antiaversive effect of zimelidine and propranolol injected into the dorsal midbrain central grey. J. Psychopharmacol., 2, 26–32.

    Article  PubMed  CAS  Google Scholar 

  • Audi, E. A., de Oliveira, C. E. and Graeff, F. G. (1989). Serotonergic mediation of the anxiolytic effect of intracerebrally injected propranolol measured in the elevated plus-maze. Braz. J. Med. Biol. Res., 22, 699–701.

    PubMed  CAS  Google Scholar 

  • Bandler, R. (1984). Identification of hypothalamic and midbrain periaqueductal grey neurones mediating aggressive and defensive behaviour by intracerebral microinjections of excitatory aminoacids. In Bandler, R. (ed.), Modulation of Sensorimotor Activity during Alterations in Behavioral States, Liss, New York, 369–91.

    Google Scholar 

  • Beart, P. M., Nicopoulos, L. S., West, D. C. and Headley, P. M. (1988). An excitatory amino acid projection from ventromedial hypothalamus to periaqueductal gray in the rat: autogradiographic and electrophysiological evidence. Neurosci. Lett., 85, 205–11.

    Article  PubMed  CAS  Google Scholar 

  • Blier, P., de Montigny, C. and Chaput, Y. (1987). Modifications of the serotonin system by the antidepressant treatments: implications for the therapeutic response in major depression. J. Clin. Psychopharmacol., 7, 24S–35S.

    Google Scholar 

  • Bovier, P., Broekkamp, C. L. E. and Lloyd, K. G. (1982). Enhancing GABAergic transmission reverses the aversive state in rats induced by electrical stimulation of the periaqueductal gray region. Brain Res., 248, 313–20.

    Article  PubMed  CAS  Google Scholar 

  • Bovier, P., Broekkamp, C. L. E. and Lloyd, K. G. (1984). Ethyl alcohol on escape from electrical periaqueductal gray stimulation in rats. Pharmacol. Biochem. Behav., 21, 353–6.

    Article  PubMed  CAS  Google Scholar 

  • Brandão, M. L., de Aguiar, J. C. and Graeff, F. G. (1982). GABA mediation of the anti-aversive action of minor tranquilizers. Pharmacol. Biochem. Behav., 16, 397–402.

    Article  PubMed  Google Scholar 

  • Broekkamp, C. L. and Jenck, F. (1989). The relationship between various animal models of anxiety, fear-related psychiatric symptoms and response to serotonergic drugs. In Bevan, P., Cools, A. R. and Archer, T. (eds.), Behavioural Pharmacology of 5-HT, Erlbaum, Hillsdale, NJ, 321–35.

    Google Scholar 

  • Carobrez, A. B. (1987). Excitatory aminoacid mediation of the defense reaction. In Brandão, M. L. (ed.), Neurosciences and behavior, UFES-Gráfica, Vitória, Brazil, 21–9.

    Google Scholar 

  • Celeumans, D. L. S., Hoppenbrouwers, M. L. J. A., Gelders, Y. G. and Reyntjens, A. J. M. (1985). The influence of ritanserin, a serotonin antagonist in anxiety disorders: A double-blind placebo-controlled study versus lorazepam. Pharmacopsychiatry, 18, 303–5.

    Article  Google Scholar 

  • Charney, W. S., Woods, W. S., Goodman, W. K. and Henninger, G. R. (1987). Serotonin function in anxiety. II: Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects. Psychopharmacology, 92, 14–24.

    Article  PubMed  CAS  Google Scholar 

  • Charney, D. S., Woods, S. W., Goodman, W. K., Rifkin, B., Kinch, M., Aiken, B., Quandrino, L. M. and Heninger, G. R. (1986). Drug treatment of panic disorder: The comparative efficacy of imipramine, alprazolam, and trazodone. J. Clin. Psychiat., 47, 580–6.

    CAS  Google Scholar 

  • Chopin, P. and Briley, M. (1987). Animal models of anxiety: the effect of compounds that modify 5-HT neurotransmission. Trends Pharmacol. Sci., 8, 383–8.

    Article  CAS  Google Scholar 

  • Chouinard, G., Annable, L., Fontaine, R. and Solyom, L. (1982). Alprazolam in the treatment of generalized anxiety and panic disorders: a double-blind placebo-controlled study. Psychopharmacology, 77, 229–32.

    Article  PubMed  CAS  Google Scholar 

  • Clarke, A. and File, S. E. (1982). Effects of ACTH, benzodiazepines and 5-HT antagonists on escape from periaqueductal grey stimulation in the rat. Biol. Psychiat., 6, 27–35.

    CAS  Google Scholar 

  • Critcheley, M. A. E. and Handley, S. L. (1987). Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors. Psychopharmacology, 93, 502–6.

    Google Scholar 

  • Deakin, J. K. W. (1989). 5-HT receptor subtypes in depression. In Bevan, P., Cools, A. R. and Archer, T. (eds.), Behavioral Pharmacology of 5-HT, Erlbaum, Hillsdale, NJ, 179–204.

    Google Scholar 

  • De Jonghe, F. (1988). Symptomatology of the depressive syndrome. In Swinkels, J. A. and Blijleven, W. (eds.), Depression, Anxiety and Aggression, Medidact, Houten, The Netherlands, 7–21.

    Google Scholar 

  • Den Boer, J. A. (1988). Serotonergic Mechanisms in Anxiety Disorders: an Inquiry into Serotonin Function in Panic Disorder. Cip-Gegevens Koeninglijke Bibliotheek, The Hague.

    Google Scholar 

  • Dunn, R. W., Corbett, R. and Fielding, S. (1989). Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze. Eur. J. Pharmacol., 169, 1–10.

    Article  PubMed  CAS  Google Scholar 

  • Eison, A. S. and Temple, D. L. (1986). Buspirone: review of its pharmacology and current perspectives on the mechanism of action. Am. J. Med., 80, Suppl. 3B, 1–9.

    Article  PubMed  CAS  Google Scholar 

  • Engel, J. A., Hjorth, S., Svensson, K., Carlson, A. and Liljequist, S. (1984). Anticonflict effect of the putative serotonin agonist 8-hydroxy-2-(DL-n-propylamino)-tetralin (8-OH-DPAT). Eur. J. Pharmacol., 105, 365–8.

    Article  PubMed  CAS  Google Scholar 

  • File, S. (1987). The search for novel anxiolytics. Trends Neurosci., 10, 461–3.

    Article  CAS  Google Scholar 

  • Fontana, D. J. and Commissaris, R. L. (1988). Effects of acute and chronic imipramine administration on conflict behavior in the rat: a potential ‘animal model’ for the study of panic? Psychopharmacology, 95, 147–50.

    Article  PubMed  CAS  Google Scholar 

  • Fontana, D. J., Carbary, T. J. and Commissaris, R. L. (1989). Effects of acute and chronic anti-panic drug administration on conflict behavior in the rat. Psychopharmacology, 98, 157–62.

    Article  PubMed  CAS  Google Scholar 

  • Frazer, G. A. and Lapierre, Y. D. (1987). The effect of buspirone on panic disorder: a case report. J. Clin. Psychopharmacol., 7, 118–9.

    PubMed  CAS  Google Scholar 

  • Gentil, V. (1988). The aversive system, 5-HT and panic attacks. In Simon, P., Soubrié, P. and Wiedlocher, D. (eds.), Selected Models of Anxiety, Depression and Psychosis, Karger, Basle, 142–5.

    Google Scholar 

  • Giral, P., Martin, P., Soubrié, P. and Simon, P. (1988). Reversal of helpless behavior in rats by putative 5-HT1A agonists. Biol. Psychiat., 23, 237–42.

    Article  PubMed  CAS  Google Scholar 

  • Goa, K. L. and Ward, A. (1986). Buspirone: a preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic. Drug Eval., 32, 114–29.

    Article  CAS  Google Scholar 

  • Goldberg, H. L. and Finnerty, R. J. (1979). The comparative efficacy of buspirone and diazepam in the treatment of anxiety. Am. J. Psychiat., 136, 1184–7.

    Article  PubMed  CAS  Google Scholar 

  • Graeff, E. O., Hunzicker, M. H. L. and Graeff, F. G. (1989). Effects of ipsapirone and BAY R 1531 on learned helplessness. Braz. J. Med. Biol. Res., 22, 1141–4.

    PubMed  CAS  Google Scholar 

  • Graeff, F. G. (1987). The antiaversive action of drugs. In Thompson, T., Dews, P. B. and Barrett, J. E. (eds.), Advances in Behavioral Pharmacology, Volume 6: Neurobehavioral Pharmacology, Erlbaum, Hillsdale, NJ, 129–56.

    Google Scholar 

  • Graeff, F. G. (1988). Animal models of aversion. In Simon, P., Soubrié, P. and Wiedlocher, D. (eds.), Selected Models of Anxiety, Depression and Psychosis, Karger, Basle, 115–41.

    Google Scholar 

  • Graeff, F. G. (1990). Brain defense systems and anxiety. In Roth, M., Burrows, G. D. and Noyes, R. (eds.), Handbook of Anxiety, vol. 3, Elsevier, Amsterdam, 307–54.

    Google Scholar 

  • Graeff, F. G. and Schoenfeld, R. I. (1970). Tryptaminergic mechanisms in punished and nonpunished behavior. J. Pharmacol. Exp. Ther., 173, 277–83.

    PubMed  CAS  Google Scholar 

  • Graeff, F. G., Carobrez, A. P. and Silveira, M. L. (1988). Excitatory amino acids and the brain aversive system. In Cavalheiro, E. A., Lehman, J. and Turski, L. (eds.), Frontiers in Excitatory Amino Acid Research, Liss, New York, 325–32.

    Google Scholar 

  • Gray, J. A. (1987). The Psychology of Fear and Stress, Cambridge University Press, Cambridge.

    Google Scholar 

  • Grunhaus, L., Gloger, S. and Weisstub, E. (1981). Panic attacks — a review of treatments and pathogenesis. J. Nerv. Ment. Dis., 169, 608–13.

    Article  PubMed  CAS  Google Scholar 

  • Guimarães, F. S., Zuardi, A. W. and Graeff, F. G. (1987). Effect of chlorimipramine and maprotiline on experimental anxiety in humans. J. Psychopharmacol., 1, 184–92.

    Article  PubMed  Google Scholar 

  • Haefely, W., Kyburz, E., Gerecke, M. and Mönier, H. (1985). Recent advances in the molecular pharmacology of benzodiazepine receptors and in the structure-activity relationship of their agonists and antagonists. Adv. Drug Res., 14, 165–322.

    CAS  Google Scholar 

  • Handley, S. L. and Mithani, S. (1984). Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ‘fear’-motivated behavior. Naunyn-Schmiedeberg’s Arch. Pharmacol., 327, 1–5.

    Article  CAS  Google Scholar 

  • Hodges, H., Green, S. and Glenn, B. (1987). Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not in discrimination. Psychopharmacology, 92, 491–504.

    Article  PubMed  CAS  Google Scholar 

  • Hoyer, D. (1988). Functional correlates of serotonin 5-HT1 recognition sites. J. Receptor Res., 8, 59–81.

    CAS  Google Scholar 

  • Jacquet, Y. F. and Lajtha, A. (1974). Paradoxical effects after microinjection of morphine in the periaqueductal gray matter. Science, 185, 1055–7.

    Article  PubMed  CAS  Google Scholar 

  • Jenck, F., Broekkamp, C. L. E. and Van Delft, A. M. L. (1989a). Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5-HT1, 5-HT2 and 5-HT3 receptors. Psychopharmacology, 97, 489–95.

    Article  PubMed  CAS  Google Scholar 

  • Jenck, F., Broekkamp, C. L. E. and Van Delft, A. M. L. (1989b). Opposite control mediated by central 5-HT1A and non-5-HT1A (5-HT1B or 5-HT1C) receptors on periaqueductal gray aversion. Eur. J. Pharmacol., 161, 219–21.

    Article  PubMed  CAS  Google Scholar 

  • Jenck, F., Broekkamp, C. L. E. and Van Delft, A. M. L. (1990a). Antidepressants on aversive PAG stimulation. Eur. J. Pharmacol., in press.

    Google Scholar 

  • Jenck, F., Broekkamp, C. L. E. and Van Delft, A. M. L. (1990b). 5-HT1C receptors in the serotonergic control of periaqueductal gray induced aversion in rats. Psychopharmacology, 100, 372–6.

    Article  PubMed  CAS  Google Scholar 

  • Johnston, A. L. and File, S. E. (1987). Pro-and anti-anxiety treatments and measures of anxiety in the rat. Soc. Neurosci. Abstr., 13, 452.

    Google Scholar 

  • Johnston, A. L. and File, S. E. (1988). Can animal tests detect panic promoting agents? Human Psychopharmacol., 3, 149–52.

    Article  Google Scholar 

  • Kahn, R. J., MacNair, D. M., Lipman, R. S., Covi, L., Rickels, K., Downing, R., Fisher, S. and Frankenthaler, L. M. (1986). Imipramine and chlordiazepoxide in depressive and anxiety disorders. II: Efficacy in anxious outpatients. Arch. Gen. Psychiat., 43, 79–85.

    Article  PubMed  CAS  Google Scholar 

  • Kahn, R. S., van Praag, H. M., Wetzler, S., Asnis, G. M. and Barr, G. (1988a). Serotonin and anxiety revisited. Biol. Psychiat., 23, 189–208.

    Article  PubMed  CAS  Google Scholar 

  • Kahn, R. S., Asnis, G. M., Wetzler, S. and van Praag, H. M. (1988b). Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder. Psychopharmacology, 96, 360–4.

    Article  PubMed  CAS  Google Scholar 

  • Kennett, G. A. and Curzon, G. (1989). Mechanism of action of 8-OH-DPAT on a rat model for human depression. In Bevan, P., Cools, A. R. and Archer, T. (eds), Behavioral Pharmacology of 5-HT, Erlbaum, Hillsdale, NJ, 225–9.

    Google Scholar 

  • Kiser, R. S. Jr and Lebovitz, R. M. (1975). Monoaminergic mechanisms in aversive brain stimulation. Physiol. Behav., 15, 47–53.

    Article  PubMed  CAS  Google Scholar 

  • Klein, D. F. (1964). Delineation of two drug responsive anxiety syndromes. Psychopharmacology, 5, 397–408.

    Article  CAS  Google Scholar 

  • Krieger, J. E. and Graeff, F. G. (1985). Defensive behavior and hypertension induced by glutamate in the midbrain central gray of the rat. Braz. J. Med. Biol. Res., 18, 61–7.

    PubMed  CAS  Google Scholar 

  • Liebowitz, M. R. (1989). Antidepressants in panic disorders. Brit. J. Psychiat., 155 (suppl. 6), 46–52.

    Google Scholar 

  • Marks, I. (1987). Agoraphobia, panic disorder and related conditions in the DSM-IIIR and ICD-10. J. Psychopharmacol., 1, 6–12.

    Article  PubMed  CAS  Google Scholar 

  • Martin, P., Laporte, A. M., Soubrié, P., El Mestikawy, S. and Hamon, M. (1989). Reversal of helpless behaviour in rats by serotonin uptake inhibitors. In Bevan, P., Cools, A. R. and Archer, T. (eds.), Behavioral Pharmacology of 5-HT, Erlbaum, Hillsdale, NJ, 231–3.

    Google Scholar 

  • Mavissakalian, M. (1988). Comments on the diagnosis and treatment of anxiety disorders. In Swinkels, J. A. and Blijleven, W. (eds), Depression, Anxiety and Aggression, Medidact, Houten, The Netherlands, 85–90.

    Google Scholar 

  • Middlemiss, D. N. (1984). Stereoselective blockade at [3H] 5-HT binding sites and at the 5-HT autoreceptor by propranolol. Eur. J. Pharmacol., 101, 289–93.

    Article  PubMed  CAS  Google Scholar 

  • Moser, P. (1989). An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone. Psychopharmacology, 99, 48–53.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, D. L., Siever, L. J. and Insel, T. R. (1985). Therapeutic responses to tricyclic antidepressants and related drugs in non-affective disorder patient populations. Prog. Neuro-Psychopharmacol. Biol. Psychiat., 9, 3–13.

    Article  CAS  Google Scholar 

  • Nashold, B. S. Jr, Wilson, N. P. and Slaughter, G. S. (1969). Sensations evoked by stimulation in the midbrain of man. J. Neurosug., 30, 14–24.

    Article  Google Scholar 

  • Nashold, B. S. Jr, Wilson, N. P. and Slaughter, G. S. (1974). The midbrain and pain. In Bonica, J.J. (ed.), Advances in Neurology, vol. 4: International Symposium on Pain, Raven, New York, 191–6.

    Google Scholar 

  • Nieuwenhuys, R. (1985). Chemoarchitecture of the Brain. Springer, Berlin.

    Book  Google Scholar 

  • Noyes, R., Anderson, D. J., Clancy, J., Crowe, R. R., Slymen, D. J., Ghoneim, M. M. and Hinrichs, J. V. (1984). Diazepam and propranolol in panic disorder and agoraphobia. Arch. Gen. Psychiat., 41, 287–92.

    Article  PubMed  Google Scholar 

  • Panksepp, J. (1982). Toward a general psychobiological theory of emotions. Behav. Brain Sci., 5, 407–67.

    Article  Google Scholar 

  • Pellow, S. and File, S.E. (1986). Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol. Biochem. Behav., 24, 525–9.

    Article  PubMed  CAS  Google Scholar 

  • Pellow, S., Johnston, A. L. and File, S. E. (1987). Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat. J. Pharm. Pharmacol., 39, 917–28.

    Article  PubMed  CAS  Google Scholar 

  • Pellow, S., Chopin, P., File, S. E. and Briley, M. (1985). Validation of open: closed arm entries in the elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Meth., 14, 149–67.

    Article  CAS  Google Scholar 

  • Schatzberg, A. F. and Cole, J. (1978). Benzodiazepines in depressive disorders. Arch. Gen. Psychiat., 35, 1359–65.

    Article  PubMed  CAS  Google Scholar 

  • Schenberg, L. C. and Graeff, F. G. (1978). Role of the periaqueductal gray substance in the antianxiety action of benzodiazepines. Pharmacol. Biochem. Behav., 9, 287–95.

    Article  PubMed  CAS  Google Scholar 

  • Schmitt, P., Di Scala, G., Brandão, M. L. and Karli, P. (1984). Periventricular structures, elaboration of aversive effects and processing of sensory information. In Bandler, R. (ed.), Modulation of Sensorimotor Activity during Alterations in Behavioral States, Liss, New York, 393–414.

    Google Scholar 

  • Schütz, M. T. B., de Aguiar, J. C. and Graeff, F. G. (1985). Antiaversive role of serotonin on the dorsal periaqueductal grey matter. Psychopharmacology, 85, 340–5.

    Article  PubMed  Google Scholar 

  • Schweitzer, E. E., Amsterdam, J., Rickels, K., Kaplan, M. and Droba, M. (1986). Open trial of buspirone in the treatment of major depressive disorder. Psychopharmacol. Bull., 22, 183–5.

    Google Scholar 

  • Scott Young, W. and Kuhar, M. J. (1980). Radiohistochemical localization of benzodiazepine receptors in the rat brain. J. Pharmacol Exp. Ther., 212, 337–46.

    Google Scholar 

  • Sheehan, D. V. (1982). Panic attacks and phobias. N. Engl. J. Med., 307, 156–8.

    Article  PubMed  CAS  Google Scholar 

  • Sheehan, D. V., Raj, A. B., Harnett-Sheehan, K. and Soto, S. (1988). The relative efficacy of buspirone, imipramine and placebo in panic disorder: a preliminary report. Pharmacol Biochem. Behav., 29, 815–7.

    Article  PubMed  CAS  Google Scholar 

  • Sheehan, D. V., Davidson, J., Manschreck, T., Van Wyck Fleet, J. (1983). Lack of efficacy of a new antidepressant (bupropion) in the treatment of panic disorders with phobias. J. Clin. Psychopharmacol., 3, 28–31.

    Article  PubMed  CAS  Google Scholar 

  • Shepherd, J. K. and Rodgers, R. J. (1989). Acute and chronic effects of the triazolobenzodiazepine, alprazolam, on defeat and analgesia evoked by conspecific attack in male mice. Behav. Pharmacol., 1, 75–83.

    Article  PubMed  Google Scholar 

  • Soubrié, P. (1986). Reconciling the role of central serotonin neurons in human and animal behavior. Behav. Brain Sci., 9, 319–64.

    Article  Google Scholar 

  • Soubrié, P. (1989). 5-HT1A receptors: a bridge between anxiety and depression? In Bevan, P., Cools, A. R. and Archer, T. (eds.), Behav. Pharmacol., of 5-HT, Erlbaum, Hillsdale, NJ, 337–52.

    Google Scholar 

  • Spier, S. A., Rosenbaum, J. F. and Woods, S. W. (1986). Treatment of panic disorder and agoraphobia with clonazepam. J. Clin. Psychiat., 47, 238–42.

    CAS  Google Scholar 

  • Stein, L., Wise, C. D. and Berger, B. D. (1973). Antianxiety action of benzodiazepines: decrease in activity of serotonin neurons in the punishment system. In Garattini, S., Mussini, E. and Randall, L. O. (eds.), Benzodiazepines, Raven, New York, 299–326.

    Google Scholar 

  • Stephens, D. N. and Andrews, J. S. (1988). N-methyl-D-aspartate antagonists in animal models of anxiety. In Cavalheiro, E. A., Lehman, J. and Turski, L. (eds.), Frontiers in Excitatory Amino Acid Research, Liss, New York, 309–16.

    Google Scholar 

  • Teicher, M. H. (1988). Biology of anxiety. Med. Clin. North America, 72, 791–814.

    CAS  Google Scholar 

  • Tiller, J., Schweitzer, I., Macquire, K. and Davies, B. (1989). Is diazepam an antidepressant? Brit. J. Psychiat., 155, 483–9.

    Article  PubMed  CAS  Google Scholar 

  • Traber, J. and Glaser, T. (1987). 5-HT receptor-related anxiolytics. Trends Pharmacol. Sci., 8, 432–7.

    Article  CAS  Google Scholar 

  • Treit, D. (1985). Animal models for the study of anti-anxiety agents: a review. Neurosci. Biobehav. Rev., 9, 203–22.

    Article  PubMed  CAS  Google Scholar 

  • Tyrer, P. (1986). Classification of anxiety disorders: a critique of DSM-III. J. Affect. Disorders, 11, 99–104.

    Article  PubMed  CAS  Google Scholar 

  • Tyrer, P. (1988). Current status of β-blocking drugs in the treatment of anxiety disorders. Drugs, 36, 773–83.

    Article  PubMed  CAS  Google Scholar 

  • Watkins, J. C. (1986). Selective antagonists define sub-classes of excitatory amino acid receptors. In Iversen, L. L. and Goodman, E. C. (eds.), Fast and Slow Chemical Signalling in the Nervous System, Oxford University Press, Oxford, 89–105.

    Google Scholar 

  • Willner, P. (1985). Antidepressants and serotonergic neurotransmission: an integrative review. Psychopharmacology, 85, 387–404.

    Article  PubMed  CAS  Google Scholar 

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Graeff, F.G. (1991). Neurotransmitters in the Dorsal Periaqueductal Grey and Animal Models of Panic Anxiety. In: Briley, M., File, S.E. (eds) New Concepts in Anxiety. Palgrave, London. https://doi.org/10.1007/978-1-349-11847-2_22

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