Skip to main content
SpringerLink
Log in

Trace elements in dialysis patients

  • Chapter
Replacement of Renal Function by Dialysis

Abstract

Aside from the organic uremic toxins it has become evident during recent decades that inorganic solutes may also be responsible for some of the symptomatology of the uremic state. Hence, interest in trace element accumulation/deficiency and the potential toxic consequences of disturbed concentrations of these substances has grown rapidly (1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alfrey AC. Trace elements and regular dialysis. In: Maher JF, editor. Replacement of Renal Function by Dialysis. Dordrecht: Kluwer, 1989:996–1003.

    Chapter  Google Scholar 

  2. Seiler HG, Sigel A, Sigel H. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994.

    Google Scholar 

  3. D’Haese PC, De Broe ME. Adequacy of dialysis: trace elements in dialysis fluids. Nephrol Dial Transplant. 1996; 11(Suppl. 2):92–7.

    Article  PubMed  Google Scholar 

  4. Coburn JW, Alfrey AC. Conference on Aluminum-related Disease. New York: Springer-Verlag, 1986.

    Google Scholar 

  5. De Broe ME, Coburn JW. Aluminum and Renal Failure. Dordrecht: Kluwer, 1989.

    Google Scholar 

  6. Van Landeghem GF, D’Haese PC, Lamberts LV, De Broe ME. A quantitative HPIEC-ETAAS hybrid technique for studying the protein binding and speciation of aluminum. Anal Chem. 1994;66:216–22.

    Article  PubMed  Google Scholar 

  7. Das AK, Chakraborty R, Cervera ML, de la Guardia M. Metal speciation in biological fluids — a review. Mikrochim Acta. 1996;122:209–46.

    Article  CAS  Google Scholar 

  8. Van Landeghem GF, De Broe ME, D’Haese PC. Al and Si: their speciation, distribution, and toxicity — a critical review. Clin Biochem. 1998;31,385–97.

    Article  PubMed  Google Scholar 

  9. Nordio M, Andriani M, Gerotto M, Marchini P, Zambenedetti P, Zatta P. Serum concentration of trace elements during different stages of chronic renal failure. Ital J Miner Elect Metab. 1988;12:81–6.

    Google Scholar 

  10. Altmann P, Butter KC, Plowman D, Chaput de Saintonge DM, Cunningham J, Marsh FP. Residual renal function in hemodialysis patients may protect against hyperaluminemia. Kidney Int. 1989;32:710–13.

    Article  Google Scholar 

  11. Smythe WR, Alfrey AC, Craswell PW et al. Trace metal abnormalities in chronic uremia. Ann Intern Med. 1982;96:302–10.

    Article  PubMed  CAS  Google Scholar 

  12. Blumsohn A, Morris B, Eastell R. Stable strontium absorption as a measure of intestinal calcium absorption: comparison with the double-radiotracer calcium absorption test. Clin Sci. 1994;87:363–8.

    PubMed  CAS  Google Scholar 

  13. Mahaffey KR. Biotoxicity of lead: influence of various factors. Fed Proc. 1983;42:1730–4.

    PubMed  CAS  Google Scholar 

  14. Barton JC, Conrad ME, Harrison L, Nuby S. Effects of calcium on the absorption and retention of lead. J Lab Clin Med. 1978;91:366–76.

    PubMed  CAS  Google Scholar 

  15. Ittel TH. Determinants of gastrointestinal absorption and distribution of aluminium in health and uremia. Nephrol Dial Transplant. 1993;8(Suppl. 1):17–24.

    Article  PubMed  Google Scholar 

  16. van der Voet GB, van Ginkel MF, de Wolff FA. Intestinal absorption of aluminum in rats: stimulation by citric acid and inhibition by dinitrophenol. Toxicol Appl Pharmacol. 1989;99:90–7.

    Article  PubMed  Google Scholar 

  17. Froment DPH, Molitoris BA, Buddington B, Miller N, Alfrey AC. Site and mechanism of enhanced gastrointestinal absorption of aluminum citrate. Kidney Int. 1989;36:978–84.

    Article  PubMed  CAS  Google Scholar 

  18. Ittel TH, Kinzel S, Ortmanns A, Sieberth H-G. Effect of iron status on the intestinal absorption of aluminum: a reappraisal. Kidney Int. 1996;50:1879–88.

    Article  PubMed  CAS  Google Scholar 

  19. Van Landeghem GF, D’Haese PC, Lamberts LV, De Broe ME. Competition of iron and aluminum for transferrin: the molecular basis for aluminum deposition in iron-overloaded dialysis patients? Exp Nephrol. 1997;5:239–45.

    PubMed  Google Scholar 

  20. Canavese C, Pacitti M, Salomone M et al. Strontium overload in uremic patients on regular dialytic treatment. Trans Am Soc Artif Intern Organs. 1986;32:120–2.

    CAS  Google Scholar 

  21. Hoffbrand AV, Refaie F, Davis B et al. Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients. Blood. 1998;91:295–300.

    PubMed  CAS  Google Scholar 

  22. Sunder-Plassmann G, Hörl WH. Erythropoietin and iron. Clin Nephrol. 1997;47:141–57.

    Google Scholar 

  23. Van Landeghem GF, D’Haese PC, Lamberts LV et al. Low serum aluminum values in dialysis patients with increased bone aluminum levels. Clin Nephrol. 1998;50:69–76.

    PubMed  Google Scholar 

  24. Hosokawa S, Yoshida O. Effects of erythropoietin on trace elements in patients with chronic renal failure undergoing hemodialysis. Nephron. 1993;65:414–7.

    Article  PubMed  CAS  Google Scholar 

  25. Gammelgaard B, Sandberg E. Aluminium and nickel in human albumin solutions. J Trace Elem Electrolytes Health Dis. 1989;3:39–42.

    PubMed  CAS  Google Scholar 

  26. D’Haese PC, Lamberts LV, Liang L, Boone LP, Van Waeleghem, De Broe ME. Contribution of parenteral and dialysate solutions to the aluminum accumulation in dialysis patients. Blood Purif. 1990;8:359–62.

    Article  PubMed  Google Scholar 

  27. Hawkins NM, Coffey S, Lawson MS, Delves HT. Potential aluminum toxicity in infants fed special infant formula. J Pediatr Gastroenterol Nutr. 1994;19:377–81.

    Article  PubMed  CAS  Google Scholar 

  28. Simoes J, Barata JD D’Haese PC, de Broe ME. Celanarrivequaux autres. Nephrol Dial Transplant. 1994;9: 67–8.

    PubMed  CAS  Google Scholar 

  29. Barata JD, D’Haese PC, Pires C, Lamberts LV, Simoes J, De Broe ME. Low-dose (5 mg/kg) desferrioxamine treatment in acutely aluminum-intoxicated hemodialysis patients using two drug administration schedules. Nephrol Dial Transplant. 1996;11:125–32.

    Article  PubMed  CAS  Google Scholar 

  30. D’Haese PC, Shaheen FA, Huraib SO et al. Increased silicon levels in dialysis patients due to the high silicon content in the drinking water, inadequate water treatment procedures, and concentrate contamination: a multicentre study. Nephrol Dial Transplant. 1995;10:1838–44.

    PubMed  Google Scholar 

  31. Caramelo CA, Cannata JB, Rodeles MR. Mechanisms of aluminum-induced microcytosis: lessons from accidental aluminum intoxication. Kidney Int. 1995;47:164–8.

    Article  PubMed  CAS  Google Scholar 

  32. Milacic, Benedik M, Knezevic S. Adsorption-desorption processes of aluminium, zinc and copper on plastic tubing in hacmodialysis montors. Clin Chim Acta. 1997; 265:169–244.

    Article  PubMed  CAS  Google Scholar 

  33. Leong As-Y, Disney APS, Gove DW. Spallation and migration of silicone from blood-pump tubing in patients on hemodialysis. N Engl J Med. 1982;306:135–40.

    Article  PubMed  CAS  Google Scholar 

  34. Webster JD, Parker TF, Alfrey AC et al. Acute nickel intoxication by dialysis. Ann Intern Med. 1980;82:631–4.

    Article  Google Scholar 

  35. Gallery EDM, Blomfeld D, Dixon SRA. Acute zinc toxicity in hemodialysis. Br Med J. 1972;4:331–3.

    Article  PubMed  CAS  Google Scholar 

  36. Shapiro WB, Schilb TP, Waltrous CL, Levy SR, Porush JG. Aluminum leakage from REDY sorbent cartridge. Kidney Int. 1983;23:536–9.

    Article  PubMed  CAS  Google Scholar 

  37. Parkinson JS, Ward MK, Kerr DNS. Dialysis encephalopathy, bone disease and anaemia: the aluminum intoxication syndrome during regular hemodialysis. J Clin Pathol. 1981;34:1285–94.

    Article  PubMed  CAS  Google Scholar 

  38. Klein WJ, Metz EN, Price AR. Acute copper intoxication. Arch Intern Med. 1972;129:578.

    Article  PubMed  Google Scholar 

  39. Vorbeck-Meister I, Sommer R, Vorbeck F, Hör WH. Quality of water used for haemodialysis: bacteriological and chemical parameters. Nephrol Dial Transplant. 1999; 14:666–75.

    Article  PubMed  CAS  Google Scholar 

  40. Schrooten I, Elseviers MM, Lamberts LV, De Broe ME, D’Haese PC. Increased serum strontium levels in dialysis patients. An epidemiological survey. Kidney Int. 1999;56:1888–92.

    Article  Google Scholar 

  41. Padovese P, Gallieni M, Brancaccio D et al. Trace elements in dialysis fluids and assessment of the exposure of patients on regular hemodialysis, hemofiltration and continuous ambulatory peritoneal dialysis. Nephron. 1992;61:442–8.

    Article  PubMed  CAS  Google Scholar 

  42. Chaleil D, Simon P, Tessier B, Cartier F, Allain P. Blood plasma fluoride in haemodialysed patients. Clin Chim Acta. 1986;156:105–8.

    Article  PubMed  CAS  Google Scholar 

  43. Mauras Y, Ang KS, Simon P, Tessier B, Cartier F, Allain P. Increase in blood plasma levels of boron and strontium in hemodialyzed patients. Clin Chim Acta. 1986;156:315–20.

    Article  PubMed  CAS  Google Scholar 

  44. Henderson I, Leung A, Halls D, Fell G, Dobbie J, Kennedy AC. Hyperchromiumaemia in chronic dialysis patients. Proc EDTA-ERA. 1985;22:270–5.

    Google Scholar 

  45. Saint-Georges MD, Bonnefont DJ, Bourely BA et al. Correction of selenium deficiency in hemodialyzed patients. Kidney Int. 1989;36(Suppl. 27):S274–7.

    Google Scholar 

  46. Wallaeys B, Cornelis R, Mees L, Lameire N. Trace elements in serum, packed cells, and dialysate of CAPD patients. Kidney Int. 1986;30:599–604.

    Article  PubMed  CAS  Google Scholar 

  47. Vanrenterghem D, Cornelis R, Vanholder R. Behaviour of 12 trace elements in serum of uremic patients on hemodiafiltration. J Trace Elem Electrolytes Health Dis. 1992;6: 169–74.

    CAS  Google Scholar 

  48. de Fransisco AL, Botella J, Escallada R et al. Haemodiafiltration with sorbent-regenerated ultrafiltrate as replacement fluid: a multicenter study. Nephrol Dial Transplant. 1997;12:528–34.

    Article  Google Scholar 

  49. Hdez-Jaras J, Galán A, Sanchez P. Accidental aluminum intoxication in patients undergoing acetate-free biofiltration. Nephron. 1998;78:274–7.

    Article  PubMed  CAS  Google Scholar 

  50. Surian M, Bonforte G, Scanziani R et al. Trace elements and micropollutant anions in the dialysis and reinfusion fluid prepared on-line for haemodiafiltration. Nephrol Dial Transplant. 1998;13(Suppl. 5):24–8.

    Article  PubMed  CAS  Google Scholar 

  51. Bonforte G, Surian M, Dozio B et al. Plasma or whole blood concentrations of trace elements in patients treated by haemodiafiltration with on-line prepared substitution fluid. Nephrol Dial Transplant. 1998;13(Suppl. 5):29–33.

    Article  PubMed  Google Scholar 

  52. Geldmacher-von Mallinckrodt M and Meissner D. General aspects of the role of metals in clinical chemistry. In: Seiler HG, Sigel A, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1984:13–29.

    Google Scholar 

  53. Luckey TD, Venugopal B. Metal Toxicity in Mammals Physiologic and Chemical Basis for Metal Toxicity. New York: Plenum, 1977.

    Book  Google Scholar 

  54. Smans, KA, D’Haese PC, Van Landeghem GF et al. Transferrin-mediated uptake of aluminium by human parathyroid cells results in reduced parathyroid hormone secretion. Nephrol Dial Transplant. 2000;15:1328–36.

    Article  PubMed  CAS  Google Scholar 

  55. Van Landeghem GF, D’Haese PC, Lamberts LV, Barata JD, De Broe ME. Aluminum speciation in cerebrospinal fluid of acutely intoxicated patients before and after desferrioxamine administration: a step in the understanding of the element’s neurotoxicity. Nephrol Dial Transplant. 1997;12:1692–8.

    Article  PubMed  Google Scholar 

  56. Lyle WH. Chronic dialysis and copper poisoning. N Engl J Med. 1967;276:1209–10.

    PubMed  CAS  Google Scholar 

  57. Mitchell G, Cirksena W, Samara G, Wax C. Acute fluoride intoxication in hemodialysis patients. J Am Soc Nephrol. 1980;13:47 (abstract).

    Google Scholar 

  58. D’Haese PC, Clement JP, Elseviers MM, Lamberts LV, Van de Vyver FL, De Broe ME. Value of serum aluminum monitoring in dialysis patients: a multicenter study. Nephrol Dial Transplant. 1990;5:45–53.

    Article  PubMed  Google Scholar 

  59. D’Haese PC, Couttenye M-M, De Broe ME. Diagnosis and treatment of aluminium bone disease. Nephrol Dial Transplant. 1996;11(Suppl.):74–7.

    Article  PubMed  Google Scholar 

  60. De Broe ME, Drüeke TB, Ritz E. Consensus Conference: Diagnosis and treatment of aluminum overload in end-stage renal failure patients. Nephrol Dial Transplant. 1993; 8(Suppl. 1):1–4

    Article  Google Scholar 

  61. Burwen DR, Olsen SM, Bland LA, Arduino MJ, Reid MH, Jarvis WR. Epidemic aluminum intoxication in haemodialysis patients traced to use an aluminum pump. Kidney Int. 1995;48:469–74

    Article  PubMed  CAS  Google Scholar 

  62. Berend V, van der Voet G, Boer WH. Acute aluminum encephalopathy in a dialysis center caused by a cement mortar water distribution pipe. Kidney Int. 2001;59:746–53

    Article  PubMed  CAS  Google Scholar 

  63. Smans KA, Van Landeghem GF, D’Haese PC, Couttenye MM, De Broe ME. Is there a link between erythropoietin therapy and adynamic bone disease? Nephrol Dial Transplant. 1996;11:1248–9

    PubMed  CAS  Google Scholar 

  64. Kasai K, Hori MT, Goodman WG. Transferrin enhances the antiproliferative effect of aluminum on osteoblastlike cells. Am J Physiol Endocrinol Metab. 1991;260: E537–43

    CAS  Google Scholar 

  65. Gitelman HJ, Alderman F, Perry SJ. Renal handling of silicon in normals and in patients with renal insufficiency. Kidney Int. 1992;42:957–9

    Article  PubMed  CAS  Google Scholar 

  66. Dobbie JW, Smith MJB. Urinary and serum silicon in normal and uremic individuals. Ciba Found Symp. 1986; 121:194–213

    PubMed  CAS  Google Scholar 

  67. Gitelman HJ, Alderman FR, Perry SJ. Silicon accumulation in dialysis patients. Am J Kidney Dis. 1992;19,140–3

    PubMed  CAS  Google Scholar 

  68. Parry R, Plowman D, Delves HT et al. Silicon and aluminum interactions in haemodialysis patients. Nephrol Dial Transplant. 1998;13:1759–62

    Article  PubMed  CAS  Google Scholar 

  69. Edwardson JA, Moore PB, Ferrier IN et al. Effect of silicon on gastrointestinal absorption of aluminium. Lancet. 1993;342:211–12

    Article  PubMed  CAS  Google Scholar 

  70. Shainkin-Kestenbaum R, Adler AJ, Berlyne GM. Inhibition of superoxide dismutase activity by silicon. J Trace Elem Electrolytes Health Dis. 1990;97–9

    Google Scholar 

  71. Bergonzi G, Paties C, Vassallo G et al. Dextran deposits in tissues of patients undergoing hemodialysis. Nephrol Dial Transplant. 1990;5:54–8

    Article  PubMed  CAS  Google Scholar 

  72. D’Haese PC, Van Landeghem GF, De Broe ME. Increased silicon levels in dialysis patients due to the high silicon content in the drinking water, inadequate water treatment procedures, and concentrate contamination: a multicentre study (reply letter to the editor). Nephrol Dial Transplant. 1996;11:1188–9

    Article  Google Scholar 

  73. Saldanha LF, Gonick HC, Rodriguez HJ, Marmelzat JA, Repique EV, Marcus CL. Silicon related syndrome in dialysis patients. Nephron. 1997;77:48–56

    Article  PubMed  CAS  Google Scholar 

  74. Sips AJAM, van der Vijgh JF. Strontium. In: Seiler HG, Sigel I, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994: 577–85

    Google Scholar 

  75. D’Haese PC, Schrooten I, Goodman WG et al. Increased bone strontium levels in hemodialysis patients with osteomalacia. Kidney Int. 2000;57:1107–14

    Article  PubMed  Google Scholar 

  76. Schrooten I, Cabrera W, Dauwe S et al. Strontium causes osteomalacia in chronic renal failure rats. Kidney Int. 1998;54:448–56

    Article  PubMed  CAS  Google Scholar 

  77. Schrooten I, Behets GJS, Cabrera WE et al. Dose-dependent effects of strontium on bone of chronic renal failure rats. Kidney Int. 2003;63:927–35

    Article  PubMed  CAS  Google Scholar 

  78. Verberckmoes SC, De Broe ME, D’Haese PC. Dose-dependent effects of strontium on osteoblast function and mineralization. Kidney Int. 2003;64:534–43

    Article  PubMed  CAS  Google Scholar 

  79. Marchante-Gayon JM, Sanchez-Uria JE, Sanz-Medel A. Serum and tissue selenium contents related to renal disease and colon cancer as determined by electrothermal atomic absorption spectrometry. J Trace Elem Med Biol. 1997; 10:229–36.

    Article  Google Scholar 

  80. Neve J, Vertongen F, Molle L. Selenium deficiency. Clin Endocrinol Metab. 1985;14:629–56

    Article  PubMed  CAS  Google Scholar 

  81. Willett WC, Morris JS, Pressel S et al. Prediagnostic serum selenium and risk of cancer. Lancet. 1983;2:130–3

    Article  PubMed  CAS  Google Scholar 

  82. Bonomini M, Forster S, De Risio F et al. Effects of selenium supplementation on immune parameters in chronic uraemic patients on haemodialysis. Nephrol Dial Transplant. 1995;10:1654–61

    PubMed  CAS  Google Scholar 

  83. Rukgauer M, Schmitt Y, Schneider H, Krusejarres JD. Trace element balance in patients undergoing hemodialysis. Trace Elem Electrolytes. 1994;11:155–68

    Google Scholar 

  84. Borguet F, Cornelis R, Delanghe J, Kambert MC, Lameire N. Study of the chromium binding to plasma of patients on continuous ambulatory peritoneal dialysis. Clin Chim Acta. 1995;238:71–84

    Article  PubMed  CAS  Google Scholar 

  85. D’Haese PC, Couttenye M-M, Lamberts LV et al. Al, Fe, Pb, Cd, Cu, Zn, Cr, Mg, Sr and Ca content in bone of endstage renal failure patients. Clin Chem. 1999;45:1548–56

    PubMed  Google Scholar 

  86. Mahajan SK, Bowersox EM, Rye DL et al. Factors underlying abnormal zinc metabolism in uremia. Kidney Int. 1989;36:S269–73

    Google Scholar 

  87. Richard MJ, Arnud J, Jurkovitz C et al. Trace element lipid peroxidation abnormalities in patients with chronic renal failure. Nephron. 1991;57:10–15

    Article  PubMed  CAS  Google Scholar 

  88. Türk S, Bozfakioglu S, Ecder ST et al. Effects of zinc supplementation on the immune system and on antibody response to multivalent influenza vaccine in hemodialysis patients. Int J Artif Organs. 1998;21:274–8

    PubMed  Google Scholar 

  89. Thomson NP, Stevens BJ, Humphery TJ, Atkins RC. Comparison of trace elements in peritoneal dialysis, hemodialysis and uremia. Kidney Int. 1983;23:9–14

    Article  PubMed  CAS  Google Scholar 

  90. Drazniowsky M, Parkinson IS, Ward MK, Channon SM, Kerr DNS. Raised serum nickel concentrations in chronic renal failure. Proc EDTA-ERA. 1984;21:241–6

    Google Scholar 

  91. Hosokawa S, Yoshida O. Serum vanadium levels in chronic hemodialysis patients. Nephron. 1993;64:388–94

    Article  PubMed  CAS  Google Scholar 

  92. Sakurai H, Nishida M, Koyama M, Takada J. Occurrence of vanadium ion in serum albumins. Biochem Biophys Acta. 1987;924:562–3

    Article  PubMed  CAS  Google Scholar 

  93. De Kimpe J, Cornelis R, Mees L, Van Lierde S, Vanholder R. More than tenfold increase of arsenic in serum of packed cells of chronic hemodialysis patients. Am J Nephrol. 1993;13:429–34

    Article  PubMed  Google Scholar 

  94. Iffland R. Arsenic. In: Seiler HG, Sigel A, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994:237–53

    Google Scholar 

  95. Zhang X, Cornelis R, Mees L, Vanholder R, Lameire N. Chemical speciation of arsenic in serum of uraemic patients. Analyst. 1998;123:3–17

    Article  Google Scholar 

  96. Gessner BD, Beller M, Middaugh JP, Whitford GM. Acute fluoride poisoning from a public water system. N Engl J Med. 1994;330:95–9

    Article  PubMed  CAS  Google Scholar 

  97. Hillier S, Cooper C, Kellingray S, Russell G, Hughes H, Coggon D. Fluoride in drinking water and risk of hip fracture in the UK: a case-control study. Lancet. 2000;355: 265–9

    Article  PubMed  CAS  Google Scholar 

  98. Turner CH, Owan I, Brizendine EJ, Zhang W, Wilson ME, Dunipace AJ. High fluoride intakes cause osteomalacia and diminished bone strength in rats with renal deficiency. Bone. 1996;19:595–601

    Article  PubMed  CAS  Google Scholar 

  99. Al-Wakeel JS, Mitwalli AH, Huraib S et al. Serum ionic fluoride levels in haemodialysis and continuous ambulatory peritoneal dialysis patients. Nephrol Dial Transplant. 1997;12:1420–4.

    Article  PubMed  CAS  Google Scholar 

  100. Ittel TH, Gladziwa U, Sieberth HG. Synergistic effect of 1,25-vitamin D3 and fluoride on bone aluminum accumulation. Bone. 1993;14:427–32.

    Article  PubMed  CAS  Google Scholar 

  101. Alfrey AC. Gastrointestinal absorption of aluminum. Clin Nephrol. 1985;24:S84–7.

    PubMed  Google Scholar 

  102. Hunt CD, Herbel JL, Odso JP. Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. J Bone Miner Res. 1994;9:171–82

    Article  PubMed  CAS  Google Scholar 

  103. Krachler M, Scharfetter H, Wirnsberger GH. Evaluation of concentrations of cesium and rubidium in whole blood, plasma, and serum in different diseases. Trace Elem Electrolytes. 1998;15:22–7

    CAS  Google Scholar 

  104. Keller T, Gehring L, Loser T. Trace element disorders in patients with chronic kidney failure during dialysis. Nieren Hochdruckkrankheiten. 1998;27:522–32

    Google Scholar 

  105. Gallieni M, Brancaccio D, Cozzolino M, Sabbioni E. Trace elements in renal failure: are they clinically important? Nephrol Dial Transplant. 1996;11:1232–5

    Article  PubMed  CAS  Google Scholar 

  106. Carroll BJ, Sharp PT. Rubidium and lithium: opposite effects on amine-mediated excitement. Science. 1971; 172:1355–7

    Article  PubMed  CAS  Google Scholar 

  107. Stiefel EJ. Proposed molecular mechanism for the action of molybdenum in enzymes: coupled proton and electron transfers. Proc Natl Acad Sci USA. 1973;70:988

    Article  PubMed  CAS  Google Scholar 

  108. Moriwaki Y, Yamamoto T, Higashino K. Distribution and pathophysiologic role of molybdenum-containing enzymes. Histol Histopathol. 1997;12:513–24

    PubMed  CAS  Google Scholar 

  109. Johnson S. Effect of gradual accumulation of iron, molybdenum and sulfur, slow depletion of zinc and copper, ethanol and fructose ingestion and phlebotomy in gout. Med Hypotheses. 1999;53:407–12

    Article  PubMed  CAS  Google Scholar 

  110. Anke M, Glei M. Molybdenum. In: Seiler HG, Sigel A, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994:495–501

    Google Scholar 

  111. Hsu WA, Lee KC, Lin SL et al. Clinical manifestations of trace metal abnormality in hemodialysis patients: a multicenter collaborative study. Dialy Transplant. 1997;26:15

    Google Scholar 

  112. Lyon TDB, Fell GS. Trace elements in autopsy tissue. Food Chem. 1992;43:299–306

    Article  CAS  Google Scholar 

  113. D’Haese PC. Aluminum accumulation in patients with chronic renal failure: Monitoring, diagnosis, therapy (Ph.D thesis). Universities of Antwerp/Amsterdam, 1989

    Google Scholar 

  114. Ritz E, Koster J, De Broe ME et al. Does lead exposure contribute to the deterioration of renal function in patients with renal disease? Nephrol Dial Transplant. 1986;1: 206–7

    PubMed  CAS  Google Scholar 

  115. D’Haese PC, Couttenye M-M, Goodman WG et al. Use of the low-dose desferrioxamine test to diagnose and differentiate between patients with aluminum-related bone disease, increased risk for aluminum toxicity, or aluminum overload. Nephrol Dial Transplant. 1995;10:1874–84

    PubMed  Google Scholar 

  116. D’Haese PC, Lamberts LV, Verpooten GA et al. Urinary and biliary excretion of aluminoxamine and ferrioxamine in dogs with various renal function. Kidney Int. 1994;45: 76–84

    Article  PubMed  Google Scholar 

  117. Andress DL, Nebeker HG, Ott SM et al. Bone histologic response to deferoxamine in aluminum-related bone disease. Kidney Int. 1987;31:1344–50

    Article  PubMed  CAS  Google Scholar 

  118. Vasilakakis DM, D’Haese PC, Lamberts LV, Lemoniatou E, Digenis PN, De Broe ME. Removal of aluminoxamine and ferrioxamine by charcoal hemoperfusion and hemodialysis. Kidney Int. 1992;41:1400–7

    Article  PubMed  CAS  Google Scholar 

  119. Lameire N, Cornelis R, Vanholder R. Does abnormal trace element metabolism contribute to dialysis patient morbidity? Semin Dial. 1999;12:15–24

    Google Scholar 

  120. Nomiyama K, Nomiyama H. Some considerations in the determination of metals in biological materials. Nephrol Dial Transplant. 1989;4(Suppl.):114–19

    Google Scholar 

  121. Templeton DM. Inductively coupled plasma-atomic emission spectrometry (ICP-AES) and inductively coupled plasma-mass spectrometry (ICP-MS). In: Seiler HG, Sigel A, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994:167–80.

    Google Scholar 

Download references

Authors
  1. Patrick C. D’Haese
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marc E. De Broe
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Nephrology, Department of Medicine III, University of Vienna, Währinger Gurtel 18-20, A-1090, Vienna, Austria

    Walter H. Hörl

  2. Division of Nephrology, Centre for Internal Medicine and Dermatology, Medizinische Hochschule, Hannover, Germany

    Karl M. Koch

  3. Optimal Dialysis Research Unit, London Health Sciences Centre and The University of Western Ontario, London, Ontario, Canada

    Robert M. Lindsay

  4. Department of Nephrology, St. Bortolo Hospital, Viale Rodolfi, I-36100, Vicenza, Italy

    Claudio Ronco

  5. RenalTech International, LLC, 320 East 65th St, #116, New York, NY, 10021, USA

    James F. Winchester

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

D’Haese, P.C., De Broe, M.E. (2004). Trace elements in dialysis patients. In: Hörl, W.H., Koch, K.M., Lindsay, R.M., Ronco, C., Winchester, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2275-3_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4020-2275-3_37

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-015-7012-1

  • Online ISBN: 978-1-4020-2275-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation