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Neurons and Cell Swelling-Induced Peptide Hormone Secretion

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Mechanosensitivity of the Nervous System

Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 2))

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Abstract

Cell swelling (most often induced by extracellular hypotonicity or intracellular hypertonicity) evokes exocytosis of material stored in secretory vesicles resulting in a secretory burst of peptide hormones or enzymes from various types of cells. Swelling induces secretion from neuron axons, dendrites and bodies. Cell swelling-induced exocytosis possesses limited selectivity, cells specifically involved in water and salt regulation retain their specific response to osmotic stimuli; neurons of the hypothalamic supraoptic and paraventricular nuclei release oxytocin, vasopressin and angiotensin II and III in response to hyperosmotic stimulation. This atypical response related to their regulatory role could be obviated by GdCl3 and at these conditions general unspecific response (exocytosis) to swelling-inducing stimuli emerged. It is concluded that swelling induced exocytosis is an ancient mechanism generally present in cells, in some of them is covered by specific response mediated by specific signalling. Swelling-induced hormone secretion could have pathophysiological implications especially when induced by ischemia.

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Authors and Affiliations

  1. Slovak Academy of Sciences Vlárska 3, Institute of Experimental Endocrinology, 833 06, Bratislava, Slovak Republic

    Vladimir Štrbák

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  1. Vladimir Štrbák
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  1. Dept. Fundamental & Applied Physiology, Russian State Medical University, Ostrovitjanova Str. 1, Moscow, Russia 117997

    Andre Kamkim  & Irina Kiseleva  & 

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Štrbák, V. (2009). Neurons and Cell Swelling-Induced Peptide Hormone Secretion. In: Kamkim, A., Kiseleva, I. (eds) Mechanosensitivity of the Nervous System. Mechanosensitivity in Cells and Tissues, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8716-5_4

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