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CD40 Stimulation and Antitumor Effects

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Targeted Cancer Immune Therapy

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Abstract

CD40–CD40L interactions play an important role in the generation of humoral and cell-mediated immunity. Due to the expression of CD40 on antigen presenting cells, it has become an attractive target for immunotherapy against cancer. Recent studies have focused on using CD40 stimulation as an adjuvant, and in conjunction with cytokines and other factors to elicit antitumor responses. However, due to the pleiotropic effects of CD40 stimulation, and the wide array of cell types upon which it is expressed, new studies are also focusing on the nonimmune related consequences of systemic and local CD40 stimulation. Systemic administration of immunotherapy regimens containing CD40 stimulation via soluble ligands and agonist antibodies has been associated with some toxicities, and direct stimulation of CD40 expressed on various malignancies and vascular endothelium has elucidated a possible role for CD40 in the transformation and progression of malignancies. This review focuses on the role of CD40 stimulation in the generation of innate and adaptive antitumor responses, as well as the direct effects of CD40 stimulation on tumor survival, death, and angiogenesis.

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References

  1. Vogel, L. A., and Noelle, R. J. (1998) Semin Immunol 10, 435

    Article  CAS  PubMed  Google Scholar 

  2. Dallman, C., Johnson, P. W., and Packham, G. (2003) Apoptosis 8, 45

    Article  CAS  PubMed  Google Scholar 

  3. Tong, A. W., and Stone, M. J. (2003) Cancer Gene Ther 10, 1

    Article  CAS  PubMed  Google Scholar 

  4. van Kooten, C., and Banchereau, J. (2000) J Leukoc Biol 67, 2

    PubMed  Google Scholar 

  5. Biancone, L., Cantaluppi, V., and Camussi, G. (1999) Int J Mol Med 3, 343

    CAS  PubMed  Google Scholar 

  6. Batrla, R., Linnebacher, M., Rudy, W., Stumm, S., Wallwiener, D., and Guckel, B. (2002) Cancer Res 62, 2052

    CAS  PubMed  Google Scholar 

  7. Eliopoulos, A. G., and Young, L. S. (2004) Curr Opin Pharmacol 4, 360

    Article  CAS  PubMed  Google Scholar 

  8. Davies, C. C., Bem, D., Young, L. S., and Eliopoulos, A. G. (2005) Cell Signal 17, 729

    Article  CAS  PubMed  Google Scholar 

  9. Dempsey, P. W., Doyle, S. E., He, J. Q., and Cheng, G. (2003) Cytokine Growth Factor Rev 14, 193

    Article  CAS  PubMed  Google Scholar 

  10. van Kooten, C., and Banchereau, J. (1997) Int Arch Allergy Immunol 113, 393

    Article  PubMed  Google Scholar 

  11. Gaur, U., and Aggarwal, B. B. (2003) Biochem Pharmacol 66, 1403

    Article  CAS  PubMed  Google Scholar 

  12. Tutt, A. L., O’Brien, L., Hussain, A., Crowther, G. R., French, R. R., and Glennie, M. J. (2002) J Immunol 168, 2720

    CAS  PubMed  Google Scholar 

  13. Grewal, I. S., and Flavell, R. A. (1998) Annu Rev Immunol 16, 111

    Article  CAS  PubMed  Google Scholar 

  14. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., and Kikutani, H. (1994) Immunity, 1, 167

    Article  CAS  PubMed  Google Scholar 

  15. Callard, R. E., Armitage, R. J., Fanslow, W. C., and Spriggs, M. K. (1993) Immunol Today 14, 559

    Article  CAS  PubMed  Google Scholar 

  16. Hayward, A. R., Levy, J., Facchetti, F., Notarangelo, L., Ochs, H. D., Etzioni, A., Bonnefoy, J. Y., Cosyns, M., and Weinberg, A. (1997) J Immunol 158, 977

    CAS  PubMed  Google Scholar 

  17. Lum, H. D., Buhtoiarov, I. N., Schmidt, B. E., Berke, G., Paulnock, D. M., Sondel, P. M., and Rakhmilevich, A. L. (2006) J Leukoc Biol 79, 1181

    Article  CAS  PubMed  Google Scholar 

  18. Lum, H. D., Buhtoiarov, I. N., Schmidt, B. E., Berke, G., Paulnock, D. M., Sondel, P. M., and Rakhmilevich, A. L. (2006) Immunology 118, 261

    Article  CAS  PubMed  Google Scholar 

  19. Tian, L., Noelle, R. J., and Lawrence, D. A. (1995) Eur J Immunol 25, 306

    Article  CAS  PubMed  Google Scholar 

  20. Rakhmilevich, A. L., Buhtoiarov, I. N., Malkovsky, M., and Sondel, P. M. (2008) Cancer Immunol Immunother 57, 1151

    Article  Google Scholar 

  21. Buhtoiarov, I. N., Lum, H., Berke, G., Paulnock, D. M., Sondel, P. M., and Rakhmilevich, A. L. (2005) J Immunol 174, 6013

    CAS  PubMed  Google Scholar 

  22. Buhtoiarov, I. N., Lum, H. D., Berke, G., Sondel, P. M., and Rakhmilevich, A. L. (2006) J Immunol 176, 309

    CAS  PubMed  Google Scholar 

  23. Chen, G. G., Chu, Y. S., Chak, E. C., Leung, B. C., and Poon, W. S. (2002) J Neurooncol 57, 179

    Article  PubMed  Google Scholar 

  24. Havell, E. A., Fiers, W., and North, R. J. (1988) J Exp Med 167, 1067

    Article  CAS  PubMed  Google Scholar 

  25. Turner, J. G., Rakhmilevich, A. L., Burdelya, L., Neal, Z., Imboden, M., Sondel, P. M., and Yu, H. (2001) J Immunol 166, 89

    CAS  PubMed  Google Scholar 

  26. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A., and Alber, G. (1996) J Exp Med 184, 747

    Article  CAS  PubMed  Google Scholar 

  27. French, R. R., Taraban, V. Y., Crowther, G. R., Rowley, T. F., Gray, J. C., Johnson, P. W., Tutt, A. L., Al-Shamkhani, A., and Glennie, M. J. (2007) Blood 109, 48105

    Article  Google Scholar 

  28. Taraban, V. Y., Rowley, T. F., and Al-Shamkhani, A. (2004) J Immunol 173, 65426

    Google Scholar 

  29. Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M., Ravetch, J. V., Steinman, R. M., and Nussenzweig, M. C. (2001) J Exp Med 194, 769

    Article  CAS  PubMed  Google Scholar 

  30. Garza, K. M., Chan, S. M., Suri, R., Nguyen, L. T., Odermatt, B., Schoenberger, S. P., and Ohashi, P. S. (2000) J Exp Med 191, 2021

    Article  CAS  PubMed  Google Scholar 

  31. Steinman, R. M., and Nussenzweig, M. C. (2002) Proc Natl Acad Sci USA 99, 3518

    Article  Google Scholar 

  32. Steinman, R. M., Hawiger, D., and Nussenzweig, M. C. (2003) Annu Rev Immunol 21, 685

    Article  CAS  PubMed  Google Scholar 

  33. Sotomayor, E. M., Borrello, I., Tubb, E., Rattis, F. M., Bien, H., Lu, Z., Fein, S., Schoenberger, S., and Levitsky, H. I. (1999) Nat Med 5, 780

    Article  CAS  PubMed  Google Scholar 

  34. Diehl, L., Den Boer, A. T., van der Voort, E. I., Melief, C. J., Offringa, R., and Toes, R. E. (2000) J Mol Med 78, 3631

    Article  Google Scholar 

  35. Mackey, M. F., Gunn, J. R., Maliszewsky, C., Kikutani, H., Noelle, R. J., and Barth, R. J., Jr. (1998) J Immunol 161, 2094

    CAS  PubMed  Google Scholar 

  36. Mackey, M. F., Barth, R. J., Jr., and Noelle, R. J. (1998) J Leukoc Biol 63, 418

    CAS  PubMed  Google Scholar 

  37. Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R., and Melief, C. J. (1998) Nature 393, 480

    Article  CAS  PubMed  Google Scholar 

  38. Ridge, J. P., Di Rosa, F., and Matzinger, P. (1998) Nature 393, 474

    Article  CAS  PubMed  Google Scholar 

  39. French, R. R., Chan, H. T., Tutt, A. L., and Glennie, M. J. (1999) Nat Med 5, 548

    Article  CAS  PubMed  Google Scholar 

  40. Bennett, S. R., Carbone, F. R., Karamalis, F., Flavell, R. A., Miller, J. F., and Heath, W. R. (1998) Nature 393, 478

    Article  CAS  PubMed  Google Scholar 

  41. Sokoloff, M. H., Daneshmand, S., and Ryan, C. W. (2005) Urol Oncol 23, 289

    PubMed  Google Scholar 

  42. Sokoloff, M. H., deKernion, J. B., Figlin, R. A., and Belldegrun, A. (1996) CA Cancer J Clin 46, 284

    Article  CAS  PubMed  Google Scholar 

  43. Fyfe, G., Fisher, R. I., Rosenberg, S. A., Sznol, M., Parkinson, D. R., and Louie, A. C. (1995) J Clin Oncol 13, 688

    CAS  PubMed  Google Scholar 

  44. Fyfe, G. A., Fisher, R. I., Rosenberg, S. A., Sznol, M., Parkinson, D. R., and Louie, A. C. (1996) J Clin Oncol 14, 2410

    CAS  PubMed  Google Scholar 

  45. Rosenberg, S. A., Yang, J. C., Topalian, S. L., Schwartzentruber, D. J., Weber, J. S., Parkinson, D. R., Seipp, C. A., Einhorn, J. H., and White, D. E. (1994) JAMA 271, 907

    Article  CAS  PubMed  Google Scholar 

  46. Berner, V., Liu, H., Zhou, Q., Alderson, K. L., Sun, K., Weiss, J. M., Back, T. C., Longo, D. L., Blazar, B. R., Wiltrout, R. H., Welniak, L. A., Redelman, D., and Murphy, W. J. (2007) Nat Med 13, 354

    Article  CAS  PubMed  Google Scholar 

  47. Murphy, W. J., Welniak, L., Back, T., Hixon, J., Subleski, J., Seki, N., Wigginton, J. M., Wilson, S. E., Blazar, B. R., Malyguine, A. M., Sayers, T. J., and Wiltrout, R. H. (2003) J Immunol 170, 2727

    CAS  PubMed  Google Scholar 

  48. Shedlock, D. J., and Shen, H. (2003) Science 300, 337

    Article  CAS  PubMed  Google Scholar 

  49. Sun, J. C., and Bevan, M. J. (2003) Science 300, 339

    Article  CAS  PubMed  Google Scholar 

  50. Schuurhuis, D. H., Laban, S., Toes, R. E., Ricciardi-Castagnoli, P., Kleijmeer, M. J., van der Voort, E. I., Rea, D., Offringa, R., Geuze, H. J., Melief, C. J., and Ossendorp, F. (2000) J Exp Med 192, 145

    Article  CAS  PubMed  Google Scholar 

  51. Janssen, E. M., Droin, N. M., Lemmens, E. E., Pinkoski, M. J., Bensinger, S. J., Ehst, B. D., Griffith, T. S., Green, D. R., and Schoenberger, S. P. (2005) Nature 434, 88

    Article  CAS  PubMed  Google Scholar 

  52. Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., and Schoenberger, S. P. (2003) Nature 421, 852

    Article  CAS  PubMed  Google Scholar 

  53. Alderson, K. L., Zhou, Q., Berner, V., Wilkins, D. E., Weiss, J. M., Blazar, B. R., Welniak, L. A., Wiltrout, R. H., Redelman, D., and Murphy, W. J. (2008) J Immunol 180, 2981

    CAS  PubMed  Google Scholar 

  54. Gendelman, M., Halligan, N., Komorowski, R., Logan, B., Murphy, W. J., Blazar, B. R., Pritchard, K. A., Jr., and Drobyski, W. R. (2005) Blood 105, 428

    Article  PubMed  Google Scholar 

  55. Hixon, J. A., Anver, M. R., Blazar, B. R., Panoskaltsis-Mortari, A., Wiltrout, R. H., and Murphy, W. J. (2002) Biol Blood Marrow Transplant 8, 316

    CAS  Google Scholar 

  56. Hixon, J. A., Blazar, B. R., Anver, M. R., Wiltrout, R. H., and Murphy, W. J. (2001) Biol Blood Marrow Transplant 7, 136

    Article  CAS  Google Scholar 

  57. Lee, J. K., Seki, N., Sayers, T. J., Subleski, J., Gruys, E. M., Murphy, W. J., and Wiltrout, R. H. (2005) Cell Immunol 235, 145

    Article  CAS  PubMed  Google Scholar 

  58. Sabel, M. S., Yamada, M., Kawaguchi, Y., Chen, F. A., Takita, H., and Bankert, R.B. (2000) Cancer Immunol Immunother 49, 101

    Article  CAS  PubMed  Google Scholar 

  59. Gallagher, N. J., Eliopoulos, A. G., Agathangelo, A., Oates, J., Crocker, J., and Young, L. S. (2002) Mol Pathol 55, 110

    Article  CAS  PubMed  Google Scholar 

  60. Rokhlin, O. W., Bishop, G. A., Hostager, B. S., Waldschmidt, T. J., Sidorenko, S. P., Pavloff, N., Kiefer, M. C., Umansky, S. R., Glover, R. A., and Cohen, M. B. (1997) Cancer Res 57, 1758

    CAS  PubMed  Google Scholar 

  61. Thomas, W. D., Smith, M. J., Si, Z., and Hersey, P. (1996) Int J Cancer 68, 795

    Article  CAS  PubMed  Google Scholar 

  62. Ziebold, J. L., Hixon, J., Boyd, A., and Murphy, W. J. (2000) Arch Immunol Ther Exp 48, 225

    CAS  Google Scholar 

  63. Altenburg, A., Baldus, S. E., Smola, H., Pfister, H., and Hess, S. (1999) J Immunol 162, 4140

    CAS  PubMed  Google Scholar 

  64. Hess, S., and Engelmann, H. (1996) J Exp Med 183, 159

    Article  CAS  PubMed  Google Scholar 

  65. Young, L. S., Eliopoulos, A. G., Gallagher, N. J., and Dawson, C. W. (1998) Immunol Today 19, 502

    Article  CAS  PubMed  Google Scholar 

  66. Hirano, A., Longo, D. L., Taub, D. D., Ferris, D. K., Young, L. S., Eliopoulos, A. G., Agathanggelou, A., Cullen, N., Macartney, J., Fanslow, W. C., and Murphy, W. J. (1999) Blood 93, 2999

    CAS  PubMed  Google Scholar 

  67. Baxendale, A. J., Dawson, C. W., Stewart, S. E., Mudaliar, V., Reynolds, G., Gordon, J., Murray, P. G., Young, L. S., and Eliopoulos, A. G. (2005) Oncogene 24, 7913

    Article  CAS  PubMed  Google Scholar 

  68. Voorzanger-Rousselot, N., Alberti, L., and Blay, J. Y. (2006) BMC Cancer 6, 75

    Article  PubMed  Google Scholar 

  69. Szocinski, J. L., Khaled, A. R., Hixon, J., Halverson, D., Funakoshi, S., Fanslow, W. C., Boyd, A., Taub, D. D., Durum, S. K., Siegall, C. B., Longo, D. L., and Murphy, W. J. (2002) Blood 100, 217

    Article  CAS  PubMed  Google Scholar 

  70. Murphy, W. J., Funakoshi, S., Beckwith, M., Rushing, S. E., Conley, D. K., Armitage, R. J., Fanslow, W. C., Rager, H. C., Taub, D. D., Ruscetti, F. W. et al. (1995) Blood 86, 1946

    CAS  PubMed  Google Scholar 

  71. Funakoshi, S., Longo, D. L., Beckwith, M., Conley, D. K., Tsarfaty, G., Tsarfaty, I., Armitage, R. J., Fanslow, W. C., Spriggs, M. K., and Murphy, W. J. (1994) Blood 83, 2787

    CAS  PubMed  Google Scholar 

  72. Voorzanger-Rousselot, N., and Blay, J. Y. (2004) Leuk Lymphoma 45, 1239–1245

    Article  CAS  PubMed  Google Scholar 

  73. Tong, A. W., Papayoti, M. H., Netto, G., Armstrong, D. T., Ordonez, G., Lawson, J. M., and Stone, M. J. (2001) Clin Cancer Res 7, 691

    CAS  PubMed  Google Scholar 

  74. Wischhusen, J., Schneider, D., Mittelbronn, M., Meyermann, R., Engelmann, H., Jung, G., Wiendl, H., and Weller, M. (2005) J Neuroimmunol 162, 28

    Article  CAS  PubMed  Google Scholar 

  75. Eliopoulos, A. G., Davies, C., Knox, P. G., Gallagher, N. J., Afford, S. C., Adams, D. H., and Young, L. S. (2000) Mol Cell Biol 20, 5503

    Article  CAS  PubMed  Google Scholar 

  76. Melichar, B., Patenia, R., Gallardo, S., Melicharova, K., Hu, W., and Freedman, R. S. (2007) Gynecol Oncol 104, 707

    Article  CAS  PubMed  Google Scholar 

  77. Shorts, L., Weiss, J. M., Lee, J. K., Welniak, L. A., Subleski, J., Back, T., Murphy, W. J., and Wiltrout, R. H. (2006) J Immunol 176, 6543

    CAS  PubMed  Google Scholar 

  78. Mach, F., Schonbeck, U., Sukhova, G. K., Bourcier, T., Bonnefoy, J. Y., Pober, J. S., and Libby, P. (1997) Proc Natl Acad Sci USA 94, 1931

    Article  CAS  PubMed  Google Scholar 

  79. Reinders, M. E., Sho, M., Robertson, S. W., Geehan, C. S., and Briscoe, D. M. (2003) J Immunol 171, 1534

    CAS  PubMed  Google Scholar 

  80. Melter, M., Reinders, M. E., Sho, M., Pal, S., Geehan, C., Denton, M. D., Mukhopadhyay, D., and Briscoe, D. M. (2000) Blood 96, 3801

    CAS  PubMed  Google Scholar 

  81. Romero, J. M., Aptsiauri, N., Vazquez, F., Cozar, J. M., Canton, J., Cabrera, T., Tallada, M., Garrido, F., and Ruiz-Cabello, F. (2006) Tissue Antigens 68, 303

    Article  CAS  PubMed  Google Scholar 

  82. Chiodoni, C., Iezzi, M., Guiducci, C., Sangaletti, S., Alessandrini, I., Ratti, C., Tiboni, F., Musiani, P., Granger, D. N., and Colombo, M. P. (2006) J Exp Med 203, 2441

    Article  CAS  PubMed  Google Scholar 

  83. Hamzah, J., Nelson, D., Moldenhauer, G., Arnold, B., Hammerling, G. J., and Ganss, R. (2008) J Clin Invest 118, 1691

    Article  CAS  PubMed  Google Scholar 

  84. Georgopoulos, N. T., Steele, L. P., Thomson, M. J., Selby, P. J., Southgate, J., and Trejdosiewicz, L. K. (2006) Cell Death Differ 13, 1789

    Article  CAS  PubMed  Google Scholar 

  85. Law, C. L., Gordon, K. A., Collier, J., Klussman, K., McEarchern, J. A., Cerveny, C. G., Mixan, B. J., Lee, W. P., Lin, Z., Valdez, P., Wahl, A. F., and Grewal, I. S. (2005) Cancer Res 65, 8331

    Article  CAS  PubMed  Google Scholar 

  86. Francisco, J. A., Donaldson, K. L., Chace, D., Siegall, C. B., and Wahl, A. F. (2000) Cancer Res 60, 3225

    CAS  PubMed  Google Scholar 

  87. Kelley, S. K., Gelzleichter, T., Xie, D., Lee, W. P., Darbonne, W. C., Qureshi, F., Kissler, K., Oflazoglu, E., and Grewal, I. S. (2006) Br J Pharmacol 148, 1116

    Article  CAS  PubMed  Google Scholar 

  88. Erickson, L. D., Durell, B. G., Vogel, L. A., O’Connor, B. P., Cascalho, M., Yasui, T., Kikutani, H., and Noelle, R. J. (2002) J Clin Invest 109, 613

    CAS  PubMed  Google Scholar 

  89. Uhlig, H. H., McKenzie, B. S., Hue, S., Thompson, C., Joyce-Shaikh, B., Stepankova, R., Robinson, N., Buonocore, S., Tlaskalova-Hogenova, H., Cua, D. J., and Powrie, F. (2006) Immunity 25, 309

    Article  CAS  PubMed  Google Scholar 

  90. Suntharalingam, G., Perry, M. R., Ward, S., Brett, S. J., Castello-Cortes, A., Brunner, M. D., and Panoskaltsis, N. (2006) N Engl J Med 355, 1018

    Article  CAS  PubMed  Google Scholar 

  91. Muller, N., van den Brandt, J., Odoardi, F., Tischner, D., Herath, J., Flugel, A., and Reichardt, H. M. (2008) J Clin Invest 118, 1405

    Article  PubMed  Google Scholar 

  92. Beyersdorf, N., Hanke, T., Kerkau, T., and Hunig, T. (2005) Ann Rheum Dis 64 (Suppl 4), iv91

    Article  CAS  PubMed  Google Scholar 

  93. Beyersdorf, N., Gaupp, S., Balbach, K., Schmidt, J., Toyka, K. V., Lin, C. H., Hanke, T., Hunig, T., Kerkau, T., and Gold, R. (2005) J Exp Med 202, 445

    Article  CAS  PubMed  Google Scholar 

  94. Schmidt, J., Elflein, K., Stienekemeier, M., Rodriguez-Palmero, M., Schneider, C., Toyka, K. V., Gold, R., and Hunig, T. (2003) J Neuroimmunol 140, 143

    Article  CAS  PubMed  Google Scholar 

  95. Legrand, N., Cupedo, T., van Lent, A. U., Ebeli, M. J., Weijer, K., Hanke, T., and Spits, H. (2006) Blood 108, 238

    Article  Google Scholar 

  96. Stebbings, R., Findlay, L., Edwards, C., Eastwood, D., Bird, C., North, D., Mistry, Y., Dilger, P., Liefooghe, E., Cludts, I., Fox, B., Tarrant, G., Robinson, J., Meager, T., Dolman, C., Thorpe, S. J., Bristow, A., Wadhwa, M., Thorpe, R., and Poole, S. (2007) J Immunol 179, 3325

    CAS  PubMed  Google Scholar 

  97. Nguyen, D. H., Hurtado-Ziola, N., Gagneux, P., and Varki, A. (2006) Proc Natl Acad Sci USA 103, 7765

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Microbiology and Immunology 320, School of Medicine, University of Nevada, Reno, NV, 89557-0320, USA

    William J. Murphy

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  1. Sidney Kimmel Cancer Center, Altman Row 10835, San Diego, 92121, U.S.A.

    Joseph Lustgarten

  2. Health Sciences Center, Louisiana State University, Bolivar Street 533, New Orleans, 70112, U.S.A.

    Yan Cui

  3. School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, 70803, U.S.A.

    Shulin Li

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Wilkins, D.E.C., Murphy, W.J. (2009). CD40 Stimulation and Antitumor Effects. In: Lustgarten, J., Cui, Y., Li, S. (eds) Targeted Cancer Immune Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0170-5_13

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