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Genetic Modifiers of Risk of BRCA1- and BRCA2-Related Breast and Ovarian Cancers

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The Role of Genetics in Breast and Reproductive Cancers

Part of the book series: Cancer Genetics ((CANGENETICS))

Abstract

Mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancers as well as other cancers [1,2]. Several studies have estimated the breast and ovarian cancer risks associated with BRCA1 and BRCA2 mutations [3–11]. Initial studies, based on families with multiple affected individuals, estimated that the risk of breast cancer by age 70 is 85% in BRCA1 and 84% in BRCA2 mutation carriers

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Authors and Affiliations

  1. Queensland Institute of Medical Research, RBH Post Office, QLD 4029, Herston, Australia

    Georgia Chenevix-Trench

  2. Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CBI 8RN, Cambridge, UK

    Antonis C. Antoniou

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  1. Georgia Chenevix-Trench
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Correspondence to Georgia Chenevix-Trench .

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  1. Division of Medical Genetics, University of Washington, Seattle, 98195-7720, U.S.A.

    Piri Welcsh

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Chenevix-Trench, G., Antoniou, A.C. (2009). Genetic Modifiers of Risk of BRCA1- and BRCA2-Related Breast and Ovarian Cancers. In: Welcsh, P. (eds) The Role of Genetics in Breast and Reproductive Cancers. Cancer Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0477-5_6

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