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Site-Directed Therapy for Lung Cancer Metastases

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Lung Cancer Metastasis

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Abstract

At the time of diagnosis, 40% of patients with non-small cell lung cancer (NSCLC) and nearly 70% of patients with small cell lung cancer (SCLC) have advanced metastatic disease. The prognosis of patients with advanced lung cancer is dismal, with a 5-year overall survival rate of 1–2%. The primary treatment of advanced disease is supportive care and palliative chemotherapy. However, there is a growing body of evidence suggesting that highly selected patients with oligometastatic disease can achieve long-term survival with ablative forms of site-directed therapy, including surgical resection, external beam radiation therapy (EBRT), stereotactic radiosurgery (SRS), stereotactic body radiation therapy (SBRT), and radiofrequency ablation (RFA). This chapter summarizes the experience with site-directed therapy in the management of metastatic lung cancer in the most commonly involved sites: brain, adrenal gland, liver, lung, and bone.

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Authors and Affiliations

  1. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA

    Kevin S Oh

  2. Department of Radiology, University of Michigan, 48109, Ann Arbor, MI, USA

    Baskaran Sundaram M.B.B.S., M.R.C.P., F.R.C.R., Venkataramu Krishnamurthy M.D. & Ella A Kazerooni M.D., M.S.

  3. Section of Thoracic Surgery, Department of Surgery, University of Michigan, 48109, Ann Arbor, MI, USA

    Allan Pickens M.D.

  4. Department of Internal Medicine, Sinai-Grace/Wayne State University, Detroit, MI, USA

    Malini Venkatram M.D.

  5. Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA

    Charlie Pan M.D. & James Hayman M.D., M.B.A.

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  1. Dept. Internal Medicine, University of Michigan Health System, Zina Pitcher Place 109, Ann Arbor, 48109-2200, U.S.A.

    Venkateshwar Keshamouni

  2. Dept. Internal Medicine, University of Michigan, E. Medical Center Drive 1500, Ann Arbor, 48109, U.S.A.

    Douglas Arenberg

  3. Dept. Internal Medicine, University of Michigan, E. Medical Center Drive 1500, Ann Arbor, 48109, U.S.A.

    Gregory Kalemkerian

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Oh, K.S. et al. (2009). Site-Directed Therapy for Lung Cancer Metastases. In: Keshamouni, V., Arenberg, D., Kalemkerian, G. (eds) Lung Cancer Metastasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0772-1_16

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