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Protein Dynamics

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The Physics of Proteins

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Proteins are not static as shown in texts; they fluctuate continuously. Moreover, the “working protein” consists not only of the folded chain of amino acids. Proteins are surrounded by their hydration shell and are embedded in a bulk solvent. The protein proper, the hydration shell, and the bulk solvent are all involved in the protein motions and all three are necessary for the functions. Protein motions are transitions between different conformational substates that are described by the energy landscape (EL ). The energy landscape has already been introduced and will be described in more detail in the present chapter. The experimental exploration of the EL is largely done by studying protein motions. We have therefore put the cart before the horse by treating the EL first. The reason is logic. Once the concept of a hierarchical EL is accepted, the existence of various types of motions is a logical consequence.

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  1. Theory Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA

    Hans Frauenfelder

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  1. Hans Frauenfelder
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  1. Technology, Department of Physics, Hong Kong University of Science &, Kowloon, ,, Hong Kong/PR China

    Shirley S. Chan

  2. , Grainger Engineering Library Information, University of Illinois at Urbana-Champai, Urbana, 61801, USA

    Winnie S. Chan

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Frauenfelder, H. (2010). Protein Dynamics. In: Chan, S., Chan, W. (eds) The Physics of Proteins. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1044-8_15

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