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Extra-Colonic Manifestations of Familial Adenomatous Polyposis Coli

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APC Proteins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 656))

Abstract

The most important clinical manifestation of Familial Adenomatous Polyposis (FAP) is a profuse polyposis predisposing to colorectal cancer. This clinical picture emphasises the fundamental cellular role of APC in colorectal tumorigenesis. As prophylactic colorectal surgery has significantly reduced the mortality associated with this disorder, other less penetrant signs and symptoms of the condition are becoming more clinically relevant. Highlighting these problems will help improve the quality oflife for patients with FAP and may have the additional benefit of shedding new light on other possible functions of the APC protein.

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Authors and Affiliations

  1. Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Australia

    Alison H. Trainer

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  1. Alison H. Trainer
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Correspondence to Alison H. Trainer .

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Editors and Affiliations

  1. Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK

    Inke S. Näthke

  2. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

    Brooke M. McCartney

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Trainer, A.H. (2009). Extra-Colonic Manifestations of Familial Adenomatous Polyposis Coli. In: Näthke, I.S., McCartney, B.M. (eds) APC Proteins. Advances in Experimental Medicine and Biology, vol 656. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1145-2_10

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