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Medication Considerations

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Insomnia and Anxiety

Part of the book series: Series in Anxiety and Related Disorders ((SARD))

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Abstract

Despite the general efficacy of CBT for insomnia, this form of therapy is generally not the first intervention chosen for the majority of treatment seeking insomnia sufferers. Most are seen in primary care settings where they usually are treated with some form of hypnotic medication. Many of those who eventually present for a trial of CBT do so while continuing hypnotic medications prescribed for their sleep difficulties. Additionally, many people with insomnia may continue using medications to manage their sleep problems for long periods of time despite less than optimal benefits and their ongoing desires to become medication free. Also, many insomnia sufferers use combinations of sedating anxiolytics and prescription hypnotics in an effort to reduce their sleep-related anxiety and sleep difficulties in general. These observations spawn a number of important questions in regard to the use of CBT with such individuals. First, it is important to consider whether these people derive similar benefits from CBT, as do those who enter treatment medication free. It also seems useful to question if there is an optimal treatment protocol for people who wish to combine CBT with pharmacotherapy for insomnia. Finally, it seems useful to ascertain if CBT and other psychological techniques are useful to those who exhibit hypnotic-dependence and ultimately wish to discontinue their sleep medication use.

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References

  • Agostini, J. V., Leo-Summers, L. S., & Inouye, S. K. (2001). Cognitive and other adverse effects of diphenhydramine use in hospitalized older patients. Archives of Internal Medicine, 161(17), 2091–2097.

    Article  PubMed  Google Scholar 

  • Ancoli-Israel, S., & Roth, T. (1999). Characteristics of insomnia in the United States: Results of the 1991 National Sleep Foundation Survey I. Sleep, 2(Suppl.), S347–353.

    Google Scholar 

  • Backhaus, J., Hohagen, F., Voderholzer, U., & Riemann, D. (2001). Long-term effectiveness of a short-term cognitive-behavioral group treatment for primary insomnia. European Archives of Psychiatry and Clinical Neuroscience, 251, 35–41.

    Article  PubMed  Google Scholar 

  • Belleville, G., Guay, C., Guay, B., & Morin, C. M. (2007). Hypnotic taper with or without self-help treatment of insomnia: A randomized clinical trial. Journal of Consulting and Clinical Psychology, 75(2), 325–335.

    Article  PubMed  Google Scholar 

  • Brower, K. J., Aldrich, M., Robinson, E. A. R., Zucker, R. A., & Greden, J. F. (2001). Insomnia, self-medication, and relapse to alcoholism. The American Journal of Psychiatry, 158, 399–404.

    Article  PubMed  Google Scholar 

  • Buscemi, N., Vandermeer, B., Pandya, R., Hooton, N., Tjosvold, L., Hartling, L., et al. (2004). Melatonin for treatment of sleep disorders. Evidence Report/Technology Assessment, 108, 1–7.

    PubMed  Google Scholar 

  • Buysse, D. J., Germain, A., Moul, D., & Nofzinger, E. A. (2005). Insomnia. In D. J. Buysse (Ed.), Sleep disorders and psychiatry (pp. 29–75). Washington, DC: American Psychiatric Publishing.

    Google Scholar 

  • Carney, C. E., Edinger, J. D., Manber, R., Garson, C. S., & Segal, Z. V. (2007). Beliefs about sleep in disorders characterized by sleep and mood disturbance. Journal of Psychosomatic Research, 62(2), 179–188.

    Article  PubMed  Google Scholar 

  • Dawson, A., Lehr, P., Bigby, B. G., & Mitler, M. M. (1993). Effect of bedtime ethanol on total inspiratory resistance and respiratory drive in normal nonsnoring men. Alcoholism, Clinical and Experimental Research, 17(2), 256–262.

    Article  PubMed  Google Scholar 

  • Donath, F., Quispe, S., & Diefenbach, K. (2000). Critical evaluation of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry, 33(2), 47–53.

    Article  PubMed  Google Scholar 

  • Edinger, J. D., & Carney, C. E. (2008). Overcoming insomnia: A cognitive behavior therapy approach therapist guide. New York: Oxford University Press.

    Google Scholar 

  • Espie, C. A., Inglis, S. J., Tessier, S., & Harvey, L. (2001). The clinical effectiveness of cognitive behaviour therapy for chronic insomnia: Implementation and evaluation of a sleep clinic in general medical practice. Behaviour Research and Therapy, 39, 45–60.

    Article  PubMed  Google Scholar 

  • Espie, C. A., MacMahon, K., Kelly, H.-L., Broomfield, N. M., Douglas, N. J., Engleman, H. M., et al. (2007). Randomized clinical effectiveness trial of nurse-administered small-group cognitive behavior therapy for persistent insomnia in general practice. Sleep, 30(5), 574–584.

    PubMed  Google Scholar 

  • Gillin, J. C., Drummond, S. P. A., Clark, C. P., & Moore, P. (2005). Medication and substance abuse. In M. H. Kryger, T. Roth, & W. C. Dement (Eds.), Principles and practice of sleep medicine (4th ed., pp. 1345–1358). Philadelphia: Elsevier Saunders.

    Google Scholar 

  • Greenblatt, D. (1991). Benzodiazepine hypnotics: Sorting the pharmacokinetic facts. Journal of Clinical Psychiatry, 52(Suppl.), 4–10.

    PubMed  Google Scholar 

  • Greenblatt, D. J. (1992). Pharmacology of benzodiazepine hypnotics. Journal of Clinical Psychiatry, 53(Suppl.), 7–13.

    PubMed  Google Scholar 

  • Hauri, P. (1996). No more sleepless nights. Wiley.

    Google Scholar 

  • Hemmelgarn, B., Suissa, S., Huang, A., Boivin, J. F., & Pinard, G. (1997). Benzodiazepine use and the risk of motor vehicle crash in the elderly. The Journal of the American Medical Association, 278, 27–31.

    Article  Google Scholar 

  • Hughes, R. J., Sack, R. L., & Lewy, A. J. (1998). The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: Assessment in a clinical trial of melatonin replacement. Sleep, 21(1), 52–68.

    PubMed  Google Scholar 

  • Jacobs, G. D. (1999). Good night to insomnia. New York: Owl Books.

    Google Scholar 

  • Jacobs, G. D., Pace-Schott, E. F., Stickgold, R., & Otto, M. W. (2004). Cognitive behavior therapy and pharmacotherapy for insomnia: A randomized controlled trial and direct comparison. Archives of Internal Medicine, 164, 1888–1896.

    Article  PubMed  Google Scholar 

  • Jonas, J. M., Coleman, B. S., Sheridan, A. Q., & Kalinske, R. W. (1992). Comparative clinical profiles of triazolam versus other shorter-acting hypnotics. The Journal of Clinical Psychiatry, 53, 19–31.

    PubMed  Google Scholar 

  • Krystal, A. D., Walsh, J. K., Laska, E., Caron, J., Amato, D. A., Wessel, T. C., et al. (2003). Sustained efficacy of eszopiclone over six months of nightly treatment: Results of a randomized, double-blind, placebo controlled study in adults with chronic insomnia. Sleep, 26, 793–799.

    PubMed  Google Scholar 

  • Lichstein, K. L., Peterson, B. A., Riedel, B. W., Means, M. K., Epperson, M. T., & Aguillard, R. N. (1999). Relaxation to assist sleep medication withdrawal. Behavior Modification, 23, 379–402.

    Article  PubMed  Google Scholar 

  • Meoli, A. L., Rosen, C., Kristo, D., Kohrman, M., Gooneratne, N., Aguillard, R. N., et al. (2005). Oral nonprescription treatment for insomnia: An evaluation of products with limited evidence. Journal of Clinical Sleep Medicine, 1, 173–187.

    Google Scholar 

  • Morin, C. M., Bastien, C. H., Guay, B., Radouco-Thomas, M., Leblanc, J., & Vallieres, A. (2004). Randomized clinical trial of supervised tapering and cognitive behavior therapy to facilitate benzodiazepine discontinuation in older adults with chronic insomnia. American Journal of Psychiatry, 161, 332–342.

    Article  PubMed  Google Scholar 

  • Morin, C. M., Beaulieu-Bonneau, S., LeBlanc, M., & Savard, J. (2005). Self-help treatment for insomnia: A randomized controlled trial. Sleep, 28(10), 1319–1327.

    PubMed  Google Scholar 

  • Morin, C. M., Bootzin, R. R., Buysse, D. J., Edinger, J. D., Espie, C. A., & Lichstein, K. L. (2006). Psychological and behavioral treatment of insomnia: Update of the recent evidence (1998–2004). Sleep, 29(11), 1398–1414.

    Google Scholar 

  • Morin, C. M., Colecchi, C., Stone, J., Sood, R., & Brink, D. (1999). Behavioral and pharmacological therapies for late-life insomnia: A randomized controlled trial. The Journal of the American Medical Association, 281, 991–999.

    Article  Google Scholar 

  • Morin, C. M., Gaulier, B., Barry, T., & Kowatch, R. A. (1992). Patients’ acceptance of psychological and pharmacological therapies for insomnia. Sleep, 15, 302–305.

    PubMed  Google Scholar 

  • Morin, C. M., Vallières, A., Guay, B., Ivers, H., Savard, J., & Mérette, C. (2009). Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: A randomized controlled trial. The Journal of the American Medical Association, 301(19), 2005–2015.

    Article  Google Scholar 

  • Morin, C. M., & Wooten, V. (1996). Psychological and pharmacological approaches to treating insomnia: Critical issues in assessing their separate and combined effects. Clinical Psychology Review, 16, 521–542.

    Article  Google Scholar 

  • Nowell, P. D., Mazumdar, S., Buysse, D. J., Dew, M. A., Reynolds, C. F. I., & Kupfer, D. J. (1997). Benzodiazepines and zolpidem for chronic insomnia: A meta-analysis of treatment efficacy. The Journal of the American Medical Association, 278, 2170–2177.

    Article  Google Scholar 

  • Ohayon, M. (1996). Epidemiological study on insomnia in the general population. Sleep, 3(Suppl. 19), S7–15.

    Google Scholar 

  • Ray, W. A. (1992). Psychotropic drugs and injuries among the elderly: A review. Journal of Clinical Psychopharmacology, 12(6), 386–396.

    PubMed  Google Scholar 

  • Richardson, G. S. (2000). Managing insomnia in the primary care setting: Raising issues. Sleep, 23(Suppl. 1), S9-S12.

    PubMed  Google Scholar 

  • Roehrs, T., Kribbs, N., Zorick, F., & Roth, T. (1986). Hypnotic residual effects of benzodiazepines with repeated administration. Sleep, 9, 309–316.

    PubMed  Google Scholar 

  • Roth, T., & Roehrs, T. (1991). A review of the safety profiles of benzodiazepine hypnotics. Journal of Clinical Psychiatry, 52, 38–41.

    PubMed  Google Scholar 

  • Roth, T., Stubbs, C., & Walsh, J. K. (2005). Ramelteon, a selective MT1/MT2-receptor agonist, reduces latency to persistent sleep in a model of transient insomnia related to a novel sleep environment. Sleep, 28, 303–307.

    PubMed  Google Scholar 

  • Roth, T., Walsh, J., Krystal, A., Wessel, T., & Roehrs, T. (2005). An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia. Sleep Medicine, 6(6), 487–495.

    Article  PubMed  Google Scholar 

  • Schramm, E., Hohagen, P., Grasshoff, M., Riemann, D., Hajak, G., Weess, H., et al. (1993). Test-retest reliability and validity of the Structured Interview for Sleep Disorders according to the DSM-III-R. American Journal of Psychiatry, 150, 867–872.

    PubMed  Google Scholar 

  • Schulz, H., Stolz, C., & Müller, J. (1994). The effect of valerian extract on sleep polygraphy in poor sleepers: A pilot study. Pharmacopsychiatry, 27(4), 147–151.

    Article  PubMed  Google Scholar 

  • Schweitzer, P. K. (2005). Drugs that disturb sleep and wakefulness. In M. H. Kryger, T. Roth, & W. C. Dement (Eds.), Principles and practice of sleep medicine (4th ed., pp. 499–518). Philadelphia: Elsevier Saunders.

    Google Scholar 

  • Sironi, V. A., Miserocchi, G., & De Rui, P. L. (1984). Clonazepam withdrawal syndrome. Acta Neurologica, 6(2), 134–139.

    PubMed  Google Scholar 

  • US Food and Drug Administration. (2007). FDA requests label change for all sleep disorder drug products from http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2007/ucm108868.htm

  • Vallieres, A., Morin, C. M., & Guay, B. (2005). Sequential combinations of drug and cognitive behavioral therapy for chronic insomnia: An exploratory study. Behaviour Research and Therapy, 43(12), 1611–1630.

    Article  PubMed  Google Scholar 

  • Verbeek, I., Schreuder, K., & Declerck, G. (1999). Evaluation of short-term non-pharmacological treatment of insomnia in a clinical setting. Journal of Psychosomatic Research, 47, 369–383.

    Article  PubMed  Google Scholar 

  • Wagner, J., Wagner, M. L., & Hening, W. A. (1998). Beyond benzodiazepines: Alternative pharmacologic agents for the treatment of insomnia. The Annals of Pharmacotherapy, 32(6), 680–691.

    Article  PubMed  Google Scholar 

  • Walsh, J. K., & Engelhardt, C. L. (1999). The direct economic costs of insomnia in the United States for 1995. Sleep, 22, S386-S393.

    PubMed  Google Scholar 

  • Walsh, J. K., & Schweitzer, P. K. (1998). Ten-year trends in the pharmacological treatment of insomnia. Sleep, 22, 371–375.

    Google Scholar 

  • Wu, R., Jinfeng, B., Chungai, Z., & Chunling, L. (2006). Comparison of sleep condition and sleep-related psychological activity after cognitive behavior and pharmacological therapy for chronic insomnia. Psychotherapy and Psychosomatics, 75, 220–228.

    Article  PubMed  Google Scholar 

  • Wysowski, D., & Barash, D. (1991). Adverse behavioral reactions attributed to triazolam in the Food and Drug Administration’s Spontaneous Reporting system. Archives of Internal Medicine, 151, 1779–1783.

    Article  PubMed  Google Scholar 

  • Zhdanova, I. V., Wurtman, R. J., Regan, M. M., Taylor, J. A., Shi, J. P., & Leclair, O. U. (2001). Melatonin treatment for age-related insomnia. Journal of Clinical Endocrinology and Metabolism, 86, 4727–4730.

    Article  PubMed  Google Scholar 

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Correspondence to Colleen E. Carney .

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Carney, C.E., Edinger, J.D. (2010). Medication Considerations. In: Insomnia and Anxiety. Series in Anxiety and Related Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1434-7_5

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