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Host Susceptibility and Molecular Epidemiology

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Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer

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Abstract

Tobacco and alcohol exposures are major determinants of risk of squamous cell carcinoma of the head and neck (SCCHN), accounting for approximately threefourths of all oral and pharyngeal cancers in the U.S. and an even higher attributable fraction of laryngeal cancers [1] . Othe r exposures include human papillomavirus, dietary, occupational, medical, and other factors that may also contribute to the etiology of this disease; however, only a fraction of exposed individuals will develop SCCHN. Therefore, the role of genetic susceptibility to carcinogenic exposures must be factored into the risk assessment process. This chapter explores some of the host factors that modulate susceptibility to epithelial carcinogenesis induced by tobacco and alcohol exposures and describes some relevant molecular epidemiology association studies of single nucleotide polymorphism (SNP) and risk of SCCHN.

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  1. Department of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1365, Houston, TX, 77030, USA

    Li-E Wang, Guojun Li, Erich Sturgis & Qingyi Wei

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Wang, LE., Li, G., Sturgis, E., Wei, Q. (2010). Host Susceptibility and Molecular Epidemiology. In: Olshan, A.F. (eds) Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1472-9_8

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