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Animal Models for Studying the Pathophysiology of Ceramide

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Sphingolipids as Signaling and Regulatory Molecules

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 688))

Abstract

Bioactive sphingolipids play key roles in the regulation of several fundamental biological processes such as proliferation, apoptosis and transformation. The recent development of genetically engineered mouse (GEM) models has enabled the study of functional roles of sphingolipids in normal development and disease. In this chapter, we review the phenotypes of GEM models (knockout mice) that lack sphingolipid metabolism-related enzymes, discuss what we have learned from animal models and describe future directions of animal models in sphingolipid research.

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Authors and Affiliations

  1. Department of Pathology & Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Suite 309, MSC 908, Charleston, South Carolina, 29425, USA

    Toshihiko Kawamori

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  1. Toshihiko Kawamori
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Editors and Affiliations

  1. Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia, USA

    Charles Chalfant PhD

  2. Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina, USA

    Maurizio Del Poeta MD

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Kawamori, T. (2010). Animal Models for Studying the Pathophysiology of Ceramide. In: Chalfant, C., Poeta, M.D. (eds) Sphingolipids as Signaling and Regulatory Molecules. Advances in Experimental Medicine and Biology, vol 688. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6741-1_7

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