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The Genomics of Turner Syndrome and Sex-Biased Neuropsychiatric Disorders

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Genomics, Proteomics, and the Nervous System

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 2))

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Abstract

Turner Syndrome (TS) is a developmental disorder caused by the absence of all, or part, of an X chromosome. Subjects with TS exhibit a well-defined neurocognitive profile characterised by deficits in aspects of memory, attention and social functioning. In this chapter, we focus on recent work analysing the genomic underpinnings of these cognitive endophenotypes. Through studying TS, we are likely to gain insights into the neural processes impacted upon by X-linked genes. As males and females differ with respect to their complements of X-linked genes, work on TS may provide clues as to the genetic basis of sex-specific vulnerability to certain neuropsychiatric disorders.

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Acknowledgements

P.M.Y.L. is supported by the Biotechnology and Biological Sciences Research Council (BBSRC, UK). E.S. is supported by the Wellcome Trust and the Medical Research Council (MRC, UK). W.D. is an RCUK Fellow in Translational Research in Experimental Medicine.

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  1. Behavioural Genetics Group, Department of Psychological Medicine, School of Medicine and School of Psychology, MRC Centre for Neuropsychiatric Genetics and Genomics, University of Cardiff, Cardiff, UK

    William Davies

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  1. Phoebe M. Y. Lynn
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  2. Evangelia Stergiakouli
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  3. William Davies
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Correspondence to William Davies .

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  1. Nathan S. Kline Institute for, Psychiatric Research, New York University, Old Orangeburg Road 140, Orangeburg, 10962, New York, USA

    James D Clelland

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Lynn, P.M.Y., Stergiakouli, E., Davies, W. (2011). The Genomics of Turner Syndrome and Sex-Biased Neuropsychiatric Disorders. In: Clelland, J. (eds) Genomics, Proteomics, and the Nervous System. Advances in Neurobiology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7197-5_1

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