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Ion Mobility/Time-of-Flight Analysis of Combinatorial Library Mixtures

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High-Throughput Analysis

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Abstract

Recent developments in combinatorial synthesis and high-throughput screening (HTS) have emphasized parallel strategies for the generation and characterization of large libraries of synthetic molecules. In the era following the sequencing of the human genome [1], proteomics has been developed as a high-throughput approach to the discovery of biological target molecules that are up- or downregulated in diseased cells [2]. The identification of such targets will certainly increase the demand for combinatorial libraries of potential binding ligands that are chemically diverse, well characterized, and appropriate for screening against multiple target molecules.

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Author information

Authors and Affiliations

  1. Eli Lilly and Company, Indianapolis, IN, 46285, USA

    Catherine A. Srebalus Barnes

  2. Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA

    David E. Clemmer

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  1. Catherine A. Srebalus Barnes
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  2. David E. Clemmer
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Editor information

Editors and Affiliations

  1. GE Global Research, Schenectady, New York

    Radislav A. Potyrailo

  2. National Institute of Standards and Technology, Gaithersburg, Maryland

    Eric J. Amis

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Barnes, C.A.S., Clemmer, D.E. (2003). Ion Mobility/Time-of-Flight Analysis of Combinatorial Library Mixtures. In: Potyrailo, R.A., Amis, E.J. (eds) High-Throughput Analysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8989-5_10

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  • DOI: https://doi.org/10.1007/978-1-4419-8989-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4749-1

  • Online ISBN: 978-1-4419-8989-5

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