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Dendritic Cells in Transplantation: Origin, Immune Activation, and Allograft Tolerance

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Immunobiology of Organ Transplantation

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Abstract

For the past 30 years, since their discovery, dendritic cells (DCs) have been the focus of many studies that outline the critical role of DCs in activation and, more recently, regulation of the immune response. As will be discussed in this chapter, DCs are specialized antigen-presenting cells (APCs) that are integral to both the initiation of allograft rejection and the induction and maintenance of transplant tolerance. Both donor and recipient DCs contribute to the rejection response but it seems to be the DCs of the recipient that participate in both the acute and chronic phases of rejection. Therefore, these DCs are an ideal target for manipulation of the rejection response in favor of promoting tolerance induction. Before discussing these developing issues, we must first understand how these cells were first discovered and how we began to understand their importance in transplantation.

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Authors and Affiliations

  1. Departments of Medicine, Microbiology and Immunology, Indiana University School of Medicine, Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA

    Kena A. Swanson & David S. Wilkes

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  1. Kena A. Swanson
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  2. David S. Wilkes
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Editors and Affiliations

  1. Microbiology and Immunobiology, Division of Pulmonary and Critical Care Medicine, Indiana University School of Medicine, Indianapolis, Indiana

    David S. Wilkes M.D. (Calvin H. English Professor of Medicine) (Calvin H. English Professor of Medicine)

  2. Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, Wisconsin

    William J. Burlingham Ph.D. (Associate Professor) (Associate Professor)

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Swanson, K.A., Wilkes, D.S. (2004). Dendritic Cells in Transplantation: Origin, Immune Activation, and Allograft Tolerance. In: Wilkes, D.S., Burlingham, W.J. (eds) Immunobiology of Organ Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8999-4_12

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