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Endothelial Cell Biology: Inflammatory Biomarkers and Risk of Transplant Atherosclerosis

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Immunobiology of Organ Transplantation

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Abstract

During the past decade, major improvement in our understanding of the mechanisms for the development of atherosclerotic lesions has emerged. Inflammatory mechanisms seem to play a paramount role in the development of both the spontaneous as well the transplant associated forms of the disease1-18. The importance of inflammatory markers as predictors of spontaneous atherosclerosis has been clearly demonstrated by several publications in the recent years’-’6Circulating plasma levels of markers of vascular inflammation seem to help with the identification of people at high risk for future cardiovascular events. The same seems to be the case for patients at risk of developing transplant atherosclerosis. Patients at risk for development of the disease also show a persistent elevation of biomarkers of inflammation in blood early following the transplant procedure’18.The present chapter will focus on the causative role of inflammation in the development of transplant atherosclerosis, the relationship between inflammation and procoagulation in the allograft microvasculature and how these changes relate to subsequent atherosclerosis, and the introduction of new therapies in order to delay or prevent the development of the disease and prolong transplant survival.

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Authors and Affiliations

  1. Methodist Research Institute, Clarian Health Partners and Indiana University School of Medicine, Indianapolis, IN, USA

    Carlos A. Labarrere

  2. Institute for Clinical Chemistry, University Hospital Großhadern, Munich, Germany

    Beate R. Jaeger

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  1. Carlos A. Labarrere
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Editors and Affiliations

  1. Microbiology and Immunobiology, Division of Pulmonary and Critical Care Medicine, Indiana University School of Medicine, Indianapolis, Indiana

    David S. Wilkes M.D. (Calvin H. English Professor of Medicine) (Calvin H. English Professor of Medicine)

  2. Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, Wisconsin

    William J. Burlingham Ph.D. (Associate Professor) (Associate Professor)

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Labarrere, C.A., Jaeger, B.R. (2004). Endothelial Cell Biology: Inflammatory Biomarkers and Risk of Transplant Atherosclerosis . In: Wilkes, D.S., Burlingham, W.J. (eds) Immunobiology of Organ Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8999-4_32

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  • DOI: https://doi.org/10.1007/978-1-4419-8999-4_32

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