Skip to main content

Polybrominated Diphenyl Ethers: Human Tissue Levels and Toxicology

  • Chapter
Reviews of Environmental Contamination and Toxicology

Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 183))

Abstract

Commercially, the polybrominated diphenyl ethers (PBDEs) are available in several technical formulations. Three major commercial mixtures are referred to as deca-BDE (CAS No. 1163-19-5), octa-BDE (CAS No. 32536-52-0), and pentaBDE (CAS No. 32534-81-9). They are used as flame retardant additives in thermoplastics in large quantities (10%-30% of the total mass; Lassen et al. 1999) in a variety of polymers, textiles, and other materials to prevent or retard the spread of fire. Therefore, they are present in a wide array of consumer and industrial products, including interiors of vehicles, electrical and electronic appliances, rubber-coated electric wires, foam in upholstery, textiles (carpets and other furnishings), television and computer casings, and building materials. They are predominantly used as additive flame retardants, are relatively mobile, and may readily migrate (leach) from products into the surrounding environment during normal product use, life cycle, and disposal.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akutsu K, Kitagawa M, Nakazawa H, Makino T, Iwazaki K, Oda H, Hori S (2003) Time-trend (1973-2000) of polybrominated diphenyl ethers in Japanese mother’s milk. Chemosphere 53 (6):645–654.

    Article  PubMed  CAS  Google Scholar 

  • Anonymous (1988) Initial submission: letter from Great Lakes Chem Corp. to USEPA regarding ITC request for information on brominated flame retardants (53FR5466) with attachments, dated 05/17/88. EPA/OTS; Doc#FYI-OTS-0794-1106 1994. NTIS/ OTS 0001106. Great Lakes Chemical Corp. West Lafayette, IN.

    Google Scholar 

  • Anonymous (1996) Diphenyl ether, octabromo derivative. International Uniform Chemical Information Data-base (IUCLID) [Version 1]. European Commission, Joint Research Centre, Environment Institute, European Chemicals Bureau, Ispra (VA), Italy. [CD-ROM]

    Google Scholar 

  • Argus Research Laboratories (1985a) Embryo/fetal toxicity and teratogenic potential study of Saytex®111 administered orally via gavage to Crl: COBS® CD® (SD) BR presumed pregnant rats. Fiche No. OTS0509725 Horsham, PA.

    Google Scholar 

  • Argus Research Laboratories (1985b) Embryo/fetal toxicity and teratogenic potential study of Saytex®115 administered orally via gavage to Crl: COBS® CD® (SD) BR presumed pregnant rats. Fiche No. OTS0000973 Horsham, PA.

    Google Scholar 

  • Arias PA (2001) Brominated flame retardants-an overview. Proceedings, 2nd International Workshop on Brominated Flame Retardants, Stockholm, Sweden, May 14-16, pp 17–19.

    Google Scholar 

  • ATSDR (2002) Draft toxicological profile for polybrominated biphenyls and polybrominated diphenyl ethers. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Washington, DC.

    Google Scholar 

  • Bergman Ã…, Ostman C, Nyborn R, Sjödin A, Carlsson H, Nilsson U, Wachtmeister CA (1997) Flame retardants and plasticizers on particulate in the modern computerized indoor environment. Organohalogen Compd 33:414–419.

    CAS  Google Scholar 

  • Birnbaum LS, Staskal DF (2004) Brominated flame retardants: cause for concern? Environ Health Perspect 112 (1):9–17.

    Article  PubMed  CAS  Google Scholar 

  • Branchi I, Alleva E, Costa LG (2002) Effects of perinatal exposure to polybrominated dipheyl ethers (PBDE-99) on mouse neurobehavioural development. Neurotoxicology 23 (3):375–384.

    Article  PubMed  CAS  Google Scholar 

  • Breslin WJ, Kirk HD, Zimmer MA (1989) Teratogenic evaluation of a polybromodiphenyl oxide mixture in New Zealand white rabbits following oral exposure. Fundam Appl Toxicol 12:151–157.

    Article  PubMed  CAS  Google Scholar 

  • BSEF (2002) An introduction to brominated flame retardants. Bromine Science and Environmental Forum, Brussels, Belgium, pp 1–28. Online at http://www.BSEF.com.

    Google Scholar 

  • Carlson GP (1980a) Induction of xenobiotic metabolism in rats by brominated diphenyl ethers administered for 90 days. Toxicol Lett 6:207–212.

    Article  PubMed  CAS  Google Scholar 

  • Carlson GP (1980b) Induction of xenobiotic metabolism in rats by short-term administration of brominated diphenyl ethers. Toxicol Lett 5:19–25.

    Article  PubMed  CAS  Google Scholar 

  • Chemosphere (2002) Brominated flame retardants in the environment. Elsevier Science Ltd Pergamon, Vol 46 (5). Online at http://www.elsevier.com/local/chemosphere.

    Google Scholar 

  • Chen G, Bunce N (2003) Polybrominated diphenyl ethers as Ah receptor agonists and antagonists. Toxicol Sci 76:310–320.

    Article  PubMed  CAS  Google Scholar 

  • Chen G, Konstantinov AD, Chittim BG, Joyce EM, Bols NC, Bunce NJ (2001) Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathways. Environ Sci Technol 35 (18):3749–3756.

    Article  PubMed  CAS  Google Scholar 

  • Choi J-W, Fujimaki S, Kitamura K, Hashimoto S, Ito H, Suzuki N, Sakai S-I, Morita M (2003) Polybrominated dibenzo-p-dioxins, dibenzofurans, and diphenyl ethers in Japanese human adipose tissue. Environ Sci Technol 37 (5):817–821.

    Article  PubMed  CAS  Google Scholar 

  • COM (2000) Risk assessment of diphenyl ethers, pentabromoderivative (pentabromodiphenyl ether) CAS NO. 32534-81-9, EINCS Number: 251-084-2. Final Report of August 2000, Commision of the European Communities Reporteur, UK.

    Google Scholar 

  • COM (2001) Proposal for a Directive of the European Parliament and of the Council amending for the 24th time Council Directive 76/769/EEC relating to restrictions of the marketing and use of certain substances and preparations (pentabromodiphenyl ether). OJC 154E, 29.5. 2001; 112, Brussels.

    Google Scholar 

  • Covaci A, de Boer J, Ryan JJ, Voorspoels S, Schepens P (2002) Distribution of organobrominated and organochlorinated contaminants in Belgian human adipose tissue. Environ Res Sec A 88:210–218.

    Article  Google Scholar 

  • Crhova S, Cerna M, Grabic R, Tomsej T, Ocelka T (2002) Polybrominated flame retardants in human adipose tissue in Czech Republic inhabitants. The pilot study. Organohalogen Compd 58:241–244.

    CAS  Google Scholar 

  • Darnerud PO, Sinjari T (1996) Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroxine and TSH blood levels in rats and mice. Organohalogen Compd 29:316–319.

    CAS  Google Scholar 

  • Darnerud PO, Eriksen GS, Jóhannesson T, Larsen PB, Viluksela M (2001) Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect 109 (1):49–68.

    Article  PubMed  CAS  Google Scholar 

  • Darnerud PO, Aune M, Atuma S, Becker W, Bjerselius R, Cnattingius S, Glynn A (2002) Time trend of polybrominated diphenyl ether (PBDE) levels in breast milk from Uppsala, Sweden, 1996-2001. Organohalogen Compd 58:233–236.

    CAS  Google Scholar 

  • El Dareer SM, Kalin JR, Tillery KF, Hill DL (1987) Disposition of decabromo biphenyl ether in rats dosed intravenously or by feeding. J Toxicol Environ Health 22:405–415.

    Article  PubMed  CAS  Google Scholar 

  • Environ International Corp (2003) Tier 1 assessment of the potential health risks to children associated with exposure to the commercial pentabromodiphenyl ether product (CAS No. 32534-81-9). Presented to U.S. Environmental Protection Agency (EPA) in a Voluntary Children’s Chemical Evaluation Program Pilot (VCCEPP) by Great Lakes Chemical Corporation. West Lafayette, IN. TERA’s website at http:// www.tera.org/peer/VCCEP/OctaPenta/OctaPentaWelcome.html. Last download May 8, 2003.

    Google Scholar 

  • Environment International (2003) The state-of-science and trends of BFRs in the environment. Elsevier Science Ltd Pergamon, Vol 29 (6). Online at www.elsevier.com/ locate/envint.

    Google Scholar 

  • Eriksson P, Viberg H, Jakobsson E, Örn U, Fredriksson A (1999) PBDE, 2,2′,4,4′,5-pentabromo diphenyl ether, causes permanent neurotoxic effects during a defined period of neonatal brain development. Organohalogen Compd 40:333–336.

    CAS  Google Scholar 

  • Eriksson P, Jakobsson E, Fredriksson A (2001) Brominated flame retardants: a novel class of developmental neurotoxicants in our environment? Environ Health Perspect 109 (9):903–908.

    Article  PubMed  CAS  Google Scholar 

  • Eriksson P, Viberg H, Jakobsson E, Örn U, Fredriksson A (2002a) A brominated flame retardant, 2,2′,4,4′,5-pentabromodiphenyl ether: uptake, retention, and induction of neurobehavioral alterations in mice during a critical phase of neonatal brain development. Toxicol Sci 67 (1):98–103.

    Article  PubMed  CAS  Google Scholar 

  • Eriksson P, Viberg H, Fischer C, Wallin M, Fredriksson A (2002b) A comparison on developmental neurotoxic effects of hexabromocyclododecan, 2,2′,4,4′,5,5′-hexabromodiphenyl ether (PBDE153) and, 2,2′,4,4′,5,5′-hexachlorobiphenyl(PCB153). Organohalogen Compd 57:389–390.

    CAS  Google Scholar 

  • EU (2001) Diphenyl ether, pentabromo derivative (pentabromodiphenyl ether). European Union risk assessment report. Office for Official Publications of the European Committees, Luxembourg, pp 1–124.

    Google Scholar 

  • Evandri MG, Mastrangelo S, Costa LG, Bolle P (2003) In vitro assessment of mutagenicity and clastogenicity of BDE-99, a pentabrominated diphenyl ether flame retardant. Environ Mol Mutagen 42 (2):85–90.

    Article  PubMed  CAS  Google Scholar 

  • Fattore E, Falk-Filipsson A, Hanberg A, Bergendorff A, HÃ¥kansson H (2001) Toxicity of a technical mixture of polybrominated diphenyl ethers following 28 days of oral exposure in the rat. Proceedings 2nd International Workshop on Brominated Flame Retardants, Stockholm, Sweden, May 14-16, pp 247–248.

    Google Scholar 

  • Fernlof G, Gadhasson I, Podra K, Darnerud PO, Thuvander A (1997) Lack of effects of some individual polybrominated diphenyl ether (PBDE) and polychlorinated biphenyl (PCB) congeners on human lymphocyte functions in vitro. Toxicol Lett 90 (2-3): 189–97.

    Article  PubMed  CAS  Google Scholar 

  • Fowles JR, Fairbrother A, Baecher-Steppan L, Kerkvliet NI (1994) Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice. Toxicology 86 (1-2):49-61.

    Google Scholar 

  • GLCC (anonymous, undated) Product and data information on decabromodiphenyl oxide, octabromodiphenyl oxide and pentabromodiphenyl oxide with attachments. EPA/ OTS Doc #44-8227036. Fiche No. NTIS/OTS0525626. Great Lakes Chemical Corporation, West Lafayette, IN.

    Google Scholar 

  • Guvenius DM, Norén K (2001) Polybrominated diphenyl ethers in Swedish human milk. The follow-up study. Proceedings, 2nd International Workshop on Brominated Flame Retardants, Stockholm, Sweden, May 14-16, pp 303–305.

    Google Scholar 

  • Guvenius DM, Aronsson A, Ekman-Ordeberg G, Bergman Ã…, Norén K (2003) Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol. Environ Health Perspect 111 (9):1235–1241.

    Article  PubMed  CAS  Google Scholar 

  • Hagmar L, Bergman A (2001) Human exposure to BFRs in Europe. Proceedings, 2nd International Workshop on Brominated Flame Retardants, Stockholm, Sweden, May 14-16, pp 107–111.

    Google Scholar 

  • Hagmar L, Björk J, Sjödin A, Bergman A, Erfurth EM (2001) Plasma levels of persistent organohalogens and hormone levels in adult male humans. Arch Environ Health 56(2):138–143.

    Article  PubMed  CAS  Google Scholar 

  • Hakk H, Huwe JK, Lorentszen M (2001) A mass balance study of a commercial pentabromodiphenyl ether mixture in male Sprague-Dawley rats. Organohalogen Compd 52:5–8.

    CAS  Google Scholar 

  • Hakk H, Larsen G, Klasson-Wehler E (2002) Tissue disposition, excretion and metabolism of 2,2′,4,4′,5-pentabromodiphenyl ether (BDE-99) in the male Sprague-Dawley rat. Xenobiotica 32(5):369–382.

    Article  PubMed  CAS  Google Scholar 

  • Hale RC, La Guardia MJ, Harvey EP, Gaylor MO, Mainor TM, Duff WH (2001a) Flame retardants. Persistent pollutants in land-applied sludges. Nature (Lond) 412(6843): 140–141.

    Article  CAS  Google Scholar 

  • Hale RC, La Guardia MJ, Harvey EP, Mainor TM, Duff WH, Gaylor MO (2001b) polybrominated diphenyl ether flame retardants in Virginia freshwater fishes (USA). Environ Sci Technol 35(23):4585–4591.

    Article  PubMed  CAS  Google Scholar 

  • Hallgren S, Sinjari T, Hakansson H, Darnerud PO (2001) Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch Toxicol 75(4):200–208.

    Article  PubMed  CAS  Google Scholar 

  • Hardell L, Lindström G, van Bavel B, Wingfors H, Sundelin E, Liljegren G (1998) Concentrations of the flame retardant 2,2′,4,4′-tetrabrominated diphenyl ether in human adipose tissue in Swedish persons and the risk for non-Hodgkin’s lymphoma. Oncol Res 10:429–432.

    PubMed  CAS  Google Scholar 

  • Hardell E, Eriksson M, Lindström G, Van Bavel B, Linde A, Carlberg M, Liljegren G (2001) Case-control study on concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus antigens in the etiology of non-Hodgkin lymphoma. Leuk Lymphoma 42(4):619–629.

    Article  PubMed  CAS  Google Scholar 

  • Hardy ML, Schroeder R, Biesemeier J, Manor O (2002) Prenatal oral (gavage) developmental toxicity study of decabromodiphenyl oxide in rats. Int J Toxicol 21(2):83–91.

    Article  PubMed  CAS  Google Scholar 

  • Helleday T, Tuominen K-L, Bergman Ã…, Jenssen D (1999) Brominated flame retardants induce intragenic recombination in mammalian cells. Mutat Res 439(2): 137–147.

    Article  PubMed  CAS  Google Scholar 

  • Hirai T, Furutani H, Myouren M, Fujimine Y, Kodaira T, Hata J, Watanabe S (2002) Concentration of polybrominated diphenyl ethers (PBDEs) in the human bile in relation to those in the liver and blood. Organohalogen Compd 58:277–280.

    CAS  Google Scholar 

  • Hooper K, McDonald TA (2000) The PBDEs: an emerging environmental challenge and another reason for breast-milk monitoring programs. Environ Health Perspect 108(5): 387–392.

    Article  PubMed  CAS  Google Scholar 

  • Hooper K, She J (2003) Lessons from the polybrominated ethers (PBDEs): Precautionary principle, primary prevention, and the value of community-based body-burden monitoring using breast milk. Environ Health Perspect 111 (1): 109–114.

    Article  PubMed  Google Scholar 

  • Hovander L, Bergman A, Edgren A, Jakobsson K (2001) PBDE levels among personnel employed at a electronics dismantling plant in the Stockholm area. Proceedings, 2nd International Workshop on Brominated Flame Retardants, Stockholm, Sweden, May 14-16, pp 295–297.

    Google Scholar 

  • Huwe JK, Hakk H, Lorentzsen M (2002) A mass balance feeding study of a commercial octabromodiphenyl ether mixture in rats. Organohalogen Compd 58:229–232.

    CAS  Google Scholar 

  • IRDC (1976a) Acute toxicity study of pentabromodiphenyl ether in rats and rabbits with cover sheet and letter dated 030890. EPA/OTS Doc #86900000216. Fiche No. OTS0522286. International Research and Development Corporation, Mattawan, MI.

    Google Scholar 

  • IRDC (1976b) Acute toxicity studies in rats and rabbits with cover sheet and letter dated 030890. Data on OBDPO (DE-79). EPA/OTS Doc #86900000228. Fiche No. OTS0522296. International Research and Development Corporation, Mattawan, MI.

    Google Scholar 

  • IRDC (1977) Octabromodiphenyl ether, thirteen week feeding study in rats with attachments, cover sheet and letter dated 030890. EPA/OTS Doc #86900000229. Fiche No. OTS0522297. International Research and Development Corporation, Mattawan, MI.

    Google Scholar 

  • Jakobsson K, Thuresson K, Rylander L, Sjödin Ã…, Hagmar L, Bergman A (2002) Exposure to polybrominated diphenyl ethers and tetrabromobisphenol A among computer technicians. Chemosphere 46:709–716.

    Article  PubMed  CAS  Google Scholar 

  • Jersey GC, Frauson LE, Schueltz DJ (1976) Pulmonary clearance and tissue response following a singe intratracheal injection of decabromo-diphenyloxide (DBDO) dust in male rats. Report HETK-47298-(21), submitted to WHO by BFRIP, Dow Chemical Company, Midland, MI.

    Google Scholar 

  • KemI (1999) Phase-out of PBDEs and PBBs: report on a governmental commission. Report 2/99. National Chemicals Inspectorate, Solna, Sweden.

    Google Scholar 

  • Klasson-Wehler E, Hovander L, Bergman Ã… (1997) New organohalogens in human plasma: identification and quantification. Organohalogen Compd 33:420–425.

    Google Scholar 

  • Klasson-Wehler E, Mörck A, Hakk H (2001) Metabolism of polybrominated diphenyl ethers in the rat. Proceedings, 2nd International Workshop on Brominated Flame Retardants, Stockholm, Sweden, May 14-16, pp 93–97.

    Google Scholar 

  • Kociba RJ, Frauson LO, Humiston CG, Norris JM, Wade CE, Lisowe RW, Quast JF, Jersey GC, Jewett GL (1975) Results of a two-year dietary feeding study with decabromodiphenyl oxide (DBDPO) in rats. J Combust Toxicol 2(4):267–285.

    CAS  Google Scholar 

  • Kopp A (1990) Documentation on fire-proofing agents containing bromine. Report to European Economic Community, Brussels (in Germany), Ministry of Environment, Nature Conservation and Nuclear Safety, Bonn.

    Google Scholar 

  • Lassen C, Løkke S, Hansen E, Andersen LI (1999) Brominated flame retardants: substance flow analysis and assessment of alternatives. Project No. 494. Danish Environmental Protection Agency (DEPA), Copenhagen.

    Google Scholar 

  • Lee S-J, Kim B-H, Kim H-S, Chang Y-S (2002) Human blood levels of polybrominated diphenyl ethers in Korea. Organohalogen Compd 58:205–208.

    CAS  Google Scholar 

  • Lind Y, Aune M, Atuma S, Becker W, Bjerselius R, Glynn A, Darnerud PO (2002) Food intake of the brominated flame retardants PBDEs and HBCD in Sweden. Organohalogen Compd 58:181–184.

    CAS  Google Scholar 

  • Lioy P, Weisel C, Millette J, Eisenreich S, Vallero D, Offenberg J, Buckley B, Turpin B, Zhong M, Cohen M, Prophete C, Yang I, Stiles R, Chee G, Johson W, Porcja R, Alimokhtari S, Hale RC, Weschler C, Chen LC (2002) Characterization of dust/ smoke aerosol that settled east of the World Trade Center (WTC) in lower Manhattan after the collapse of the WTC 11 September 2001. Environ Health Perspect 110(7): 703–714.

    Article  PubMed  CAS  Google Scholar 

  • Litton Bionetics Inc. (1990a) Mutagenicity evaluation of compound 345-76a (final report). With cover sheet and letter dated 03/08/90. EPA/OTS; Doc #86-900000215. Fiche No. NTIS/OTS0522285 Kensington, MD.

    Google Scholar 

  • Litton Bionetics Inc. (1990b) Mutagenicity evaluation of compound 345-79a (final report). With cover sheet and letter dated 03/08/90. EPA/OTS; Doc#86-900000223. Fiche No. NTIS/OTS0522291 Kensington, MD.

    Google Scholar 

  • Mazdai A, Dodder NG, Abernathy MP, Hites RA, Bigsby RM (2003) Polybrominated diphenyl ethers in maternal and fetal blood samples. Environ Health Perspect 111 (9): 1249–1252.

    Article  PubMed  CAS  Google Scholar 

  • Meerts IATM, Luijks EAC, Marsh G, Jakobsson E, Bergman Ã…, Bouwer A (1998) Polybrominated diphenyl ether (PBDEs) as Ah-receptors agonists and antagonists. Organohalogen Compd 37:147–150.

    CAS  Google Scholar 

  • Meerts IATM, van Zanden JJ, Luijk EAC, van Leeuween-Bol I, Marsh G, Jakobsson E, Bergman A, Brouwer A (2000) Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol Sci 56:95–104.

    Article  PubMed  CAS  Google Scholar 

  • Meerts IATM, Letcher RJ, Hoving S, Marsh G, Bergman Ã…, Lemmen JG, Van der burg B, Brouwer A (2001) In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PBDEs, and polybrominated bisphenol A compounds. Environ Health Perspect 109 (4):399–407.

    Article  PubMed  CAS  Google Scholar 

  • Meironyté D, Norén K, Bergman Ã… (1999) Analysis of polybrominated diphenyl eyhers in Swedish human milk. A time-related trend study, 1972-1997. J Toxicol Environ Health Part A 58:329–341.

    Article  PubMed  Google Scholar 

  • Meironyté-Guvenius DM, Bergman Ã…, Norén K (2001) Polybrominated diphenyl ethers in Swedish human liver and adipose tissue. Arch Environ Contam Toxicol 40:564–570.

    Article  PubMed  Google Scholar 

  • Meneses M, Wingfors H, Schuhmacher M, Domingo JL, Lindström G, van Bavel B (1999) Polybrominated diphenyl ethers detected in human adipose tissue from Spain. Chemosphere 39 (13):2271–2278.

    Article  PubMed  CAS  Google Scholar 

  • Microbiological Associates Inc. (1996a) Octabromo diphenyl oxide (OBDPO): maximization test in guinea pigs, with cover letter dated 12-12-1996. EPA/OTS; Doc #86970000355. Fiche No. NTIS/OTS0573549 Bethesda, MD.

    Google Scholar 

  • Microbiological Associates Inc. (1996b) Pentabromo diphenyl oxide (PBDPO): Maximization test in Guinea Pigs with cover letter dated 12-12-1996. EPA/OTS; Doc #86970000359. Fiche No. NTIS/OTS0573553 Bethesda, MD.

    Google Scholar 

  • Mörck A, Klasson-Wehler E (2001) Metabolism of decabromo diphenyl ether (BDE-209) in the rat. Organohalogen Compd 52:9–12.

    Google Scholar 

  • Nagayama J, Takasuga T, Hsuji H (2001) Contamination levels of brominated flame retardants, dioxins and organochlorine compounds in the blood of Japanese adults. Proceedings, 2nd International Workshop on Brominated Flame Retardants, Stockholm, Sweden, May 14-16, pp 113–116.

    Google Scholar 

  • Norén K, Meironyté D (2000) Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 40:1111–1123.

    Article  PubMed  Google Scholar 

  • Norris JM, Kociba RJ, Schweiz B?, Rose JQ, Humiston CG, Jewett GL, Gehring PJ, Mailhes JB (1975) Toxicology of octabromo diphenyl and decabromo diphenyl oxide. Environ Health Perspect 11:153–161.

    Article  PubMed  CAS  Google Scholar 

  • NTP (1986) Toxicology and carcinogenesis studies of decabromodiphenyl oxide (CAS No. 1163-19-5) in F344/N rats and B6C3F1 mice (feed studies). Tech Rep 309. NTIS No. PB86-247780/AS. National Toxicology Program, Research Triangle Park, NC.

    Google Scholar 

  • Ohta S, Nakao T, Nishimura H, Okumura T, Aozasa O, Miyata H (2002a) Contamination levels of PBDES, TBBPA, PCDDS/DFS, PBDDS/DFS and PXDDS/DFS in the environment of Japan. Organohalogen Compd 57:57–60.

    CAS  Google Scholar 

  • Ohta S, Ishizuka D, Nishimura H, Nakao T, Aozasa O, Shimidzu Y, Ochiai F, Kida T, Nishi M, Miyata H (2002b) Comparison of polybrominated diphenyl ethers in fish, vegetables, and meats and levels in human milk of nursing women in Japan. Chemosphere 46(5):689–696.

    Article  PubMed  CAS  Google Scholar 

  • Örn U, Klasson-Wehler E (1998) Metabolism of 2,2′,4,4′-tetrabromodiphenyl ether in rat and mouse. Xenobiotica 28(2):199–211.

    PubMed  Google Scholar 

  • Petreas M, She J, Brown FR, Winkler J, Visita P, Li C, Chand D, Dhaliwal J, Rogers E, Zhao G, Charles M J (2002a) High PBDE concentrations in California human and wildlife populations. Organohalogen Compd 58:177–180.

    CAS  Google Scholar 

  • Petreas M, Rogers E, Zhao G, Windham G, Bhatia R, Charles MJ (2002b) Organohalogen body burdens in California women. Organohalogen Compd 55:259–262.

    CAS  Google Scholar 

  • Petreas M, She J, Brown FR, Winkler J, Windham G, Rogers E, Zhao G, Bhatia R, Charles MJ (2003) High body burdens of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) in California women. Environ Health Perspect 111(9): 1175–1179.

    Article  PubMed  CAS  Google Scholar 

  • Ryan JJ, Patry B (2000) Determination of brominated diphenyl ethers (BDEs) and levels in Canadian human milks. Organohalogen Compd 47:57–60.

    CAS  Google Scholar 

  • Ryan JJ, Patry B (2001) Body burdens and food exposure in Canada for polybrominated diphenyl ethers (BDEs). Organohalogen Compd 51:226–229.

    CAS  Google Scholar 

  • Ryan JJ, Patry B, Mills B, Beaudoin NG (2002) Recent trends in levels of brominated diphenyl ethers(BDEs) in human milks from Canada. Organohalogen Compd 58:173–176.

    CAS  Google Scholar 

  • Santillo D, Johnston P, Brigden K (2001) The presence of brominated flame retardants and organotin compounds in dusts collected from Parliament buildings from eight countries. Technical Note 03/2001. Greenpeace Research Laboratories, Department of Biological Sciences, University of Exeter, Exeter, UK.

    Google Scholar 

  • Schecter A, Pavuk M, Papke O, Ryan JJ, Birnbaum L, Rosen R (2003) Polybrominated diphenyl ethers (PBDEs) in U.S. mother’s milk. Environ Health Perspect 111(14): 1723–1729.

    Article  PubMed  CAS  Google Scholar 

  • Schröter-Kermani C, Helm D, Hermann T, Päpke O (2000) The German environmental specimen bank: application in trend monitoring of polybrominated diphenyl ethers in human blood. Organohalogen Compd 47:49–52.

    Google Scholar 

  • She J, Petreas M, Winkler J, Visita P, McKinney M, Kopec D (2002) PBDEs in the San Francisco Bay area: measurements in harbor seal blubber and human breast adipose tissue. Chemosphere 46:697–707.

    Article  PubMed  CAS  Google Scholar 

  • Simonson M, Tullin C, Stripple H (2002) Fire LCA study of TV sets with VO and HB enclosure material. Chemosphere 46(5):737–744.

    Article  PubMed  CAS  Google Scholar 

  • Sjödin A, Hagmar L, Klasson-Wehler E, Kronholm-Diab K, Jakobsson E, Bergman A (1999) Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers. Environ Health Perspect 107(8):643–648.

    Article  PubMed  Google Scholar 

  • Sjödin A, Hagmar L, Klasson-Wehler E, Björk J, Bergman Ã… (2000) Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men. Environ Health Perspect 108(11): 1035–1041.

    PubMed  Google Scholar 

  • Sjödin A, Patterson DG Jr, Bergman Ã… (2001a) Brominated flame retardants in serum from U.S. blood donors. Environ Sci Technol 35(19):3830–3833.

    Article  PubMed  Google Scholar 

  • Sjödin A, Carlsson H, Thuresson K, Sjölin S, Bergman Ã…, Ostman C (2001b) Flame retardants in indoor air at an electronics recycling plant and at other work environments. Environ Sci Technol 35(3):448–454.

    Article  PubMed  Google Scholar 

  • SRI (2001) Directory of Chemical Producers, United States of America. Stanford Research Institute International, Menlo Park, CA.

    Google Scholar 

  • Stanley JS, Cramer PH, Thornburg KR, Remmers JC, Breen JJ, Schwemberger J (1991) Mass spectral confirmation of chlorinated and brominated diphenyl ethers in human adipose tissues. Chemosphere 23(8-10): 1185–1195.

    Article  CAS  Google Scholar 

  • Strandman T, Koistinen J, Kiviranta H, Vuorinen PJ, Tuomisto J, Tuomisto J, Vartiainen T (1999) Levels of some polybrominated diphenyl ethers (PBDEs) in fish and human adipose tissue in Finland. Organohalogen Compd 40:355–358.

    CAS  Google Scholar 

  • Strandman T, Koistinen J, Vartiainen T (2000) Polybrominated diphenyl ethers (PBDEs) in placenta and human milk. Organohalogen Compd 47:61–64.

    CAS  Google Scholar 

  • Takasuga T, Tsuji H, Nagayama J (2002) Gender specific dynamics of PCDD/DFs, PCBs, PBDEs and organochlorines in blood of Japanese families over two-year study period. Organohalogen Compd 58:297–300.

    CAS  Google Scholar 

  • Thomsen C, Lundanes E, Becher G (2001) Brominated flame retardants in plasma samples from three different occupational groups in Norway. J Environ Monit 3: 366–370.

    Article  PubMed  CAS  Google Scholar 

  • Thomsen C, Lundanes E, Becher G (2002) Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age. Environ Sci Technol 36(7):1414–1418.

    Article  PubMed  CAS  Google Scholar 

  • Thuresson K, Jakobsson K, Hagmar L, Englyst V, Bergman A (2002a) Work related exposure to brominated flame retardants when recycling metals from printed circuit boards. Organohalogen Compd 58:249–252.

    CAS  Google Scholar 

  • Thuresson K, Jakobsson K, Hagmar L, Sjödin A, Bergman A (2002b) Decabromodi-phenyl ether exposure to workers manufacturing rubber and in an industrial setting producing rubber coated electric wires. Organohalogen Compd 58:165–168.

    CAS  Google Scholar 

  • Thuvander A, Darnerud PO (1999) Effects of polybrominated diphenyl ethers (PBDs) and polychlorinated biphenyl (PCB) on some immunological parameters after exposure in rats and mice. Toxicol Environ Chem 70:229–242.

    Article  CAS  Google Scholar 

  • TRI 99 (2001) National Library of Medicine. National Toxicology Program, Bethesda, MD. The TRI can be downloaded from the EPA website at http://www.epa.gov.tri. [Also TRI 100 (2002).]

    Google Scholar 

  • USEPA (1999) Biosolids generation, use and disposal in the United States. EPA 530-R-99-009. USEPA, Washington, DC.

    Google Scholar 

  • USEPA (2003) Integrated Risk Information System (IRIS) Office of Research and Development, U.S. Environmental Protection Agency. Online at http://www.epa.gov/iris/ index.html.

    Google Scholar 

  • Van Bavel B, Hardell L, Kitti A, Liljedahl M, Karlsson M, Pettersson A, Tysklind M, Lindström G (2002) High levels of PBDEs in 5% of 220 blood samples from the Swedish population. Organohalogen Compd 58:161–164.

    Google Scholar 

  • Viberg H, Fredriksson A, Eriksson P (2002) Neonatal exposure to the brominated flame retardant 2,2′,4,4′,5-pentabromodiphenyl ether causes altered susceptibility in the cholinergic transmitter system in the adult mouse. Toxicol Sci 67(1): 104–107.

    Article  PubMed  CAS  Google Scholar 

  • von Meyerinck L, Hufnagel B, Schmoldt A, Benthe HF (1990) Induction of rat liver microsomal cytochrome P-450 by the pentabromo diphenyl ether Bromkal 70 and half-lives of its components in the adipose tissue. Toxicology 61:259–274.

    Article  Google Scholar 

  • WHO (1994) Brominated diphenyl ethers. Environmental Health Criteria No. 162. International Program on Chemical Safety, World Health Organization (WHO), Geneva, Switzerland.

    Google Scholar 

  • WIL Research Laboratories (1984) 90-Day dietary study in rats with pentabromodiphenyl oxide (DE-71). Final report. Fiche No. NTIS/OTS0524336. EPA/OTS; Doc# 86-900000221. WIL, Ashland, OH.

    Google Scholar 

  • WIL Research Laboratories (1985) 30-Day dietary study in rats with pentabromodiphenyl oxide, including recovery periods of 6,12 and 24 weeks. Final report. Project No. 12042. WIL, Ashland, OH.

    Google Scholar 

  • Zhou T, Taylor MM, DeVito MJ, Crofton KM (2000) Thyroid hormone disruptive effects of brominated diphenyl ethers following developmental exposure. Toxicologist 54(1):260–261.

    Google Scholar 

  • Zhou T, Ross DG, DeVito MJ, Crofton KM (2001) Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol Sci 61:76–82.

    Article  PubMed  CAS  Google Scholar 

  • Zhou T, Taylor MM, DeVito MJ, Crofton KM (2002) Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol Sci 66:105–116.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science+Business Media New York

About this chapter

Cite this chapter

Gill, U., Chu, I., Ryan, J.J., Feeley, M. (2004). Polybrominated Diphenyl Ethers: Human Tissue Levels and Toxicology. In: Ware, G.W. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 183. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9100-3_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-9100-3_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6494-1

  • Online ISBN: 978-1-4419-9100-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics